"It All Ended in an Unsporting Way": Serbian Football and the Disintegration of Yugoslavia, 1989-2006

Part of a wider examination into football during the collapse of Eastern European Communism between 1989 and 1991, this article studies the interplay between Serbian football and politics during the period of Yugoslavia's demise. Research utilizing interviews with individuals directly involved in the Serbian game, in conjunction with contemporary Yugoslav media sources, indicates that football played an important proactive role in the revival of Serbian nationalism. At the same time the Yugoslav conflict, twinned with a complex transition to a market economy, had disastrous consequences for football throughout the territories of the former Yugoslavia. In the years following the hostilities the Serbian game has suffered decline, major financial hardship and continuing terrace violence, resulting in widespread nostalgia for the pre-conflict era

Effect of HIV-1 infection on T-Cell-based and skin test detection of tuberculosis infection

RATIONALE: Two forms of the IFN-gamma release assay (IFNGRA) to detect tuberculosis infection are available, but neither has been evaluated in comparable HIV-infected and uninfected persons in a high tuberculosis incidence environment. OBJECTIVE: To compare the ability of the T-SPOT.TB (Oxford Immunotec, Abingdon, UK), QuantiFERON-TB Gold (Cellestis, Melbourne, Australia), and Mantoux tests to identify latent tuberculosis in HIV-infected and uninfected persons. METHODS: A cross-sectional study of 160 healthy adults without active tuberculosis attending a voluntary counseling and testing center for HIV infection in Khayelitsha, a deprived urban South African community with an HIV antenatal seroprevalence of 33% and a tuberculosis incidence of 1,612 per 100,000. MEASUREMENTS AND MAIN RESULTS: One hundred and sixty (74 HIV(+) and 86 HIV(-)) persons were enrolled. A lower proportion of Mantoux results was positive in HIV-infected subjects compared with HIV-uninfected subjects (p < 0.01). By contrast, the proportion of positive IFNGRAs was not significantly different in HIV-infected persons for the T-SPOT.TB test (52 vs. 59%; p = 0.41) or the QuantiFERON-TB Gold test (43 and 46%; p = 0.89). Fair agreement between the Mantoux test (5- and 10-mm cutoffs) and the IFNGRA was seen in HIV-infected people (kappa = 0.52-0.6). By contrast, poor agreement between the Mantoux and QuantiFERON-TB Gold tests was observed in the HIV-uninfected group (kappa = 0.07-0.30, depending on the Mantoux cutoff). The pattern was similar for T-SPOT.TB (kappa = 0.18-0.24). Interpretation: IFNGRA sensitivity appears relatively unimpaired by moderately advanced HIV infection. However, agreement between the tests and with the Mantoux test varied from poor to fair. This highlights the need for prospective studies to determine which test may predict the subsequent risk of tuberculosis

Cytotoxic Mediators in Paradoxical HIV-Tuberculosis Immune Reconstitution Inflammatory Syndrome

Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) frequently complicates combined antiretroviral therapy and antituberculosis therapy in HIV-1–coinfected tuberculosis patients. The immunopathological mechanisms underlying TB-IRIS are incompletely defined, and improved understanding is required to derive new treatments and to reduce associated morbidity and mortality. We performed longitudinal and cross-sectional analyses of human PBMCs from paradoxical TB-IRIS patients and non-IRIS controls (HIV-TB–coinfected patients commencing antiretroviral therapy who did not develop TB-IRIS). Freshly isolated PBMC stimulated with heat-killed Mycobacterium tuberculosis H37Rv (hkH37Rv) were used for IFN-γ ELISPOT and RNA extraction. Stored RNA was used for microarray and RT-PCR, whereas corresponding stored culture supernatants were used for ELISA. Stored PBMC were used for perforin and granzyme B ELISPOT and flow cytometry. There were significantly increased IFN-γ responses to hkH37Rv in TB-IRIS, compared with non-IRIS PBMC (p = 0.035). Microarray analysis of hkH37Rv-stimulated PBMC indicated that perforin 1 was the most significantly upregulated gene, with granzyme B among the top five (log(2) fold difference 3.587 and 2.828, respectively), in TB-IRIS. Downstream experiments using RT-PCR, ELISA, and ELISPOT confirmed the increased expression and secretion of perforin and granzyme B. Moreover, granzyme B secretion reduced in PBMC from TB-IRIS patients during corticosteroid treatment. Invariant NKT cell (CD3(+)Vα24(+)) proportions were higher in TB-IRIS patients (p = 0.004) and were a source of perforin. Our data implicate the granule exocytosis pathway in TB-IRIS pathophysiology. Further understanding of the immunopathogenesis of this condition will facilitate development of specific diagnostic and improved therapeutic options

Health literacy, health status, and healthcare utilization of Taiwanese adults: results from a national survey

Abstract Background Low health literacy is considered a worldwide health threat. The purpose of this study is to assess the prevalence and socio-demographic covariates of low health literacy in Taiwanese adults and to investigate the relationships between health literacy and health status and health care utilization. Methods A national survey of 1493 adults was conducted in 2008. Health literacy was measured using the Mandarin Health Literacy Scale. Health status was measured based on self-rated physical and mental health. Health care utilization was measured based on self-reported outpatient clinic visits, emergency room visits, and hospitalizations. Results Approximately thirty percent of adults were found to have low (inadequate or marginal) health literacy. They tended to be older, have fewer years of schooling, lower household income, and reside in less populated areas. Inadequate health literacy was associated with poorer mental health (OR, 0.57; 95% CI, 0.35-0.91). No association was found between health literacy and health care utilization even after adjusting for other covariates. Conclusions Low (inadequate and marginal) health literacy is prevalent in Taiwan. High prevalence of low health literacy is not necessarily indicative of the need for interventions. Systematic efforts to evaluate the impact of low health literacy on health outcomes in other countries would help to illuminate features of health care delivery and financing systems that may mitigate the adverse health effects of low health literacy.http://deepblue.lib.umich.edu/bitstream/2027.42/78252/1/1471-2458-10-614.xmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78252/2/1471-2458-10-614.pdfPeer Reviewe

Radical nostalgia, progressive patriotism and Labour's 'English problem'

‘Progressive patriots’ have long argued that Englishness can form the basis of a transformative political project, whether based on an historic tradition of resistance to state power or an open and cosmopolitan identity. However, this article suggests that the politics of Englishness present a number of specific dilemmas for Labour. First the historical narrative of a radical tradition in British history is not straightforwardly English and cannot easily be used to support a competitive politics of nationhood, in the way that disaffected English identifiers might desire. Second, the deliberately alternative nature of this ‘radical nostalgic’ narrative makes it an unlikely basis for a unifying national story. It is also at odds with Labour’s status as a successful party of government, committed to using the power of the British state, rather than opposing it. Finally, while ‘everyday Englishness’ may well align with core Labour values and be less socially conservative, intolerant or racially exclusive than it is often described, its very nature as an everyday practice, rather than a political identity makes it difficult for Labour to co-opt

Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling

Although concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen. We investigated the hypothesis that celecoxib activates AMP kinase (AMPK) signalling to enhance vascular endothelial protection. In human arterial and venous endothelial cells (EC), and in contrast to ibuprofen and naproxen, celecoxib induced the protective protein heme oxygenase-1 (HO-1). Celecoxib derivative 2,5-dimethyl-celecoxib (DMC) which lacks COX-2 inhibition also upregulated HO-1, implicating a COX-2-independent mechanism. Celecoxib activated AMPKα(Thr172) and CREB-1(Ser133) phosphorylation leading to Nrf2 nuclear translocation. Importantly, these responses were not reproduced by ibuprofen or naproxen, while AMPKα silencing abrogated celecoxib-mediated CREB and Nrf2 activation. Moreover, celecoxib induced H-ferritin via the same pathway, and increased HO-1 and H-ferritin in the aortic endothelium of mice fed celecoxib (1000 ppm) or control chow. Functionally, celecoxib inhibited TNF-α-induced NF-κB p65(Ser536) phosphorylation by activating AMPK. This attenuated VCAM-1 upregulation via induction of HO-1, a response reproduced by DMC but not ibuprofen or naproxen. Similarly, celecoxib prevented IL-1β-mediated induction of IL-6. Celecoxib enhances vascular protection via AMPK-CREB-Nrf2 signalling, a mechanism which may mitigate cardiovascular risk in patients prescribed celecoxib. Understanding NSAID heterogeneity and COX-2-independent signalling will ultimately lead to safer anti-inflammatory drugs

National interest to global reform: patterns of reasoning in British foreign policy discourse

Discussion of the national interest often focuses on how Britain's influence can be maximized, rather than on the goals that influence serves. Yet what gives content to claims about the national interest is the means-ends reasoning which links interests to deeper goals. In ideal-typical terms, this can take two forms. The first, and more common, approach is conservative: it infers national interests and the goals they advance from existing policies and commitments. The second is reformist: it starts by specifying national goals and then asks how they are best advanced under particular conditions. New Labour's foreign policy discourse is notable for its explicit use of a reformist approach. Indeed, Gordon Brown's vision of a 'new global society' not only identifies global reform as a key means of fulfilling national goals, but also thereby extends the concept of the national interest well beyond a narrow concern with national security

Water requirements for growth and survival of Swietenia macrophylla and Tabebuia heterophylla juvenile trees in relation to water production capacity of dew condensers1

Drought mortality of juvenile trees is a major cause for failure of reforestation projects. Portable devices such as passive radiative dew condensers can often provide 0.15 L/day of water in situ, possibly sufficient for tree survival until roots can access groundwater, allowing self-sustainability. To evaluate growth and survivability of juvenile trees of Tabebuia heterophylla Britton and Swietenia macrophylla King under such low water amounts, juvenile trees received approximately 0.033, 0.067, 0.134, 0.201 and 0.268 L/tree/day, representing fractions (relative evapotranspiration or RET) of 0.125, 0.25, 0.50, 0.75 and 1.00 of the evapotranspiration demand (ETo). The experiment lasted 60 days for S. macrophylla and 90 days for T. heterophylla. All T. heterophylla juvenile trees survived even at the lowest irrigation rate. However, S. macrophylla juvenile trees began dying at RET \u3c 0.5, with only 60 percent surviving at RET = 0.25 (0.067 L/day) and 100 percent mortality occurring at RET = 0.125 (0.033 L/day). Water requirements of 0.134 L/day, necessary for full survival of both species, were within the typical production capacity of 1-m2 dew condensers. However, a greater safetyfactor is obtained using drought tolerant species such as T. heterophylla, which can survive under water application rates as low as 0.03 L/day

Experimental Evidence on Transfer Pricing

Abstract We use incentivized economics experiments to test both the point predictions and comparative static predictions of optimal transfer pricing models, comparing behavior under varying conditions, including wholly versus partially-owned subsidiaries and different tariff and tax rates. As predicted, we find that transfer prices are responsive to relative tax and tariff rates as well as ownership proportions. Additionally, we examine convergence and learning in this setting. While individuals do not choose optimal transfer prices, their choices converge to optimal levels with experience. This paper thus makes two important contributions. First, by comparing behavior with theoretical predictions it provides evidence of whether (and when) individuals set transfer prices optimally. Second, by comparing behavior under conditions of full and partial ownership it provides evidence on the impact of policy interventions (like regulating ownership proportions by MNEs) on tax revenues.</jats:p

Evaluación preliminar de condensadores de rocío y su utilización para riego de plántulas de árboles en Puerto Rico

Dew condensers have been proposed as a means to reduce drought&nbsp;mortality of tree seedlings in early stages of reforestation projects. We&nbsp;investigated the amount of dew condensate produced by locally constructed&nbsp;dew condensers, constructed with three different infrared emitting&nbsp;surfaces: standard polyethylene/ TiO2 / BaSO4 foil, thermoplastic polyolefin&nbsp;(TPO), and plastic coated with locally available Lanco UrethanizerTM8&nbsp;roofing paint. All surfaces produced similar amounts of total dew condensate,&nbsp;typically ranging between 0.05 and 0.25 L/m2/night. However, the materials&nbsp;differed in the fraction of dew running off the surfaces, which represents the&nbsp;water available for tree seedlings. Highest runoff fractions were obtained&nbsp;with painted surfaces, followed by polyethylene and polyolefin surfaces,&nbsp;respectively. Considerably greater amounts of nightly dew condensate&nbsp;were observed during the winter than in summer, attributed to differences&nbsp;in night length and cloud cover. A commercially available dew condenser,&nbsp;the Groasis WaterboxxTM, did not generate more than 0.04 L per night of&nbsp;runoff dew, due primarily to a small condenser surface area of &lt; 0.2 m2. A&nbsp;field study showed that 1 m2 dew condensers maintained the root zone of&nbsp;mahogany seedlings at matric potentials &gt; -60 kPa during dry spells. Overall,&nbsp;results indicated that passive dew condensers with condenser areas of 1 m2&nbsp;are capable of producing sufficient water for survival of small tree seedlings&nbsp;during drought periods.Los condensadores de rocío se han propuesto como mecanismo para&nbsp;proveer agua a plántulas de árboles en etapas iniciales de reforestación. Se&nbsp;investigó el potencial de condensadores de fabricación local para producir&nbsp;agua. Se compararon condensadores construidos con tres diferentes&nbsp;superficies emisoras en infrarrojo: lámina estándar de polietileno impregnado&nbsp;con TiO2 y BaSO4, poli-olefina termoplástica (TPO), y plástico recubierto con&nbsp;pintura Lanco UrethanizerTM disponible en ferreterías locales. Todas las&nbsp;superficies produjeron cantidades similares de condensado total de rocío,&nbsp;por lo general entre 0.05 y 0.25 L /m2/noche. Sin embargo, los materiales&nbsp;variaron en la fracción del condensado escurrido desde las superficies, lo&nbsp;cual representa el agua disponible para las plántulas. Las fracciones de&nbsp;escorrentía más altas se obtuvieron con las superficies pintadas, seguido&nbsp;por las superficies de polietileno y de poli-olefina, respectivamente. Las&nbsp;cantidades de condensado durante el invierno fueron mayores que en&nbsp;verano, probablemente debido a noches más largas y menor nubosidad&nbsp;en invierno. Se evaluó el volumen de rocío (escorrentía) producido por un&nbsp;modelo comercial de condensador de rocío, el Groasis WaterboxxTM. Este&nbsp;nunca superó 0.04 L por noche, atribuido principalmente a la pequeña área&nbsp;de superficie (&lt; 0.2 m2) del condensador. Un experimento de campo mostró&nbsp;que condensadores de rocío de 1 m2 mantuvieron el potencial matricial&nbsp;de agua en la zona de raíces de plántulas de caoba en valores &gt; -60 kPa&nbsp;durante periodos de sequía. En general, los resultados indicaron que los&nbsp;condensadores de rocío con áreas superficiales de 1 m2 producen suficiente&nbsp;agua para la supervivencia de pequeñas plántulas de árboles