Intergenerational Support and Marital Satisfaction: Implications of Beliefs About Helping Aging Parents

Everyday support given to aging parents is a salient aspect of married life that may have implications for marital quality. Among 132 middle‐aged couples drawn from Wave 1 of the Family Exchanges Study, the authors examined the moderating effects of each spouse’s normative and motivational beliefs about helping parents on associations between the frequency of everyday support that wives and husbands gave to their own parents and marital satisfaction. Husbands’ more frequent provision of support was linked to wives’ greater marital satisfaction when reports of personal rewards linked to helping parents were high for wives or low for husbands. Conversely, wives’ more frequent provision of support was linked to husbands’ lower marital satisfaction when reports of filial obligation were low for husbands or high for wives. Findings highlight the interdependence within couples and indicate that both spouses’ perceptions are important in understanding linkages between intergenerational support and marital satisfaction.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135490/1/jomf12334_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135490/2/jomf12334.pd

Mosaic fungal individuals have the potential to evolve within a single generation

Although cells of mushroom-producing fungi typically contain paired haploid nuclei (n + n), most Armillaria gallica vegetative cells are uninucleate. As vegetative nuclei are produced by fusions of paired haploid nuclei, they are thought to be diploid (2n). Here we report finding haploid vegetative nuclei in A. gallica at multiple sites in southeastern Massachusetts, USA. Sequencing multiple clones of a single-copy gene isolated from single hyphal filaments revealed nuclear heterogeneity both among and within hyphae. Cytoplasmic bridges connected hyphae in field-collected and cultured samples, and we propose nuclear migration through bridges maintains this nuclear heterogeneity. Growth studies demonstrate among- and within-hypha phenotypic variation for growth in response to gallic acid, a plant-produced antifungal compound. The existence of both genetic and phenotypic variation within vegetative hyphae suggests that fungal individuals have the potential to evolve within a single generation in response to environmental variation over time and space

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Spouse involvement and diabetes management in later life couples

For many adults, including older adults, a marital partner is their central social relationship and this important tie can have health implications particularly within the chronic illness context. In addition, chronic illness care has shifted from long and frequent hospital stays to outpatient care for managing illness over an extended period of time. As the interactions within a marriage are posited to influence a patient\u27s chronic illness management (see reviews Kiecolt-Glaser & Newton, 2001; Robles & Kiecolt-Glaser, 2003), the primary aim of this study is to determine the association between spouse involvement and patient chronic illness management and marital satisfaction. A second aim of this study is to explore the relational context as a potential moderator of the association of spouse involvement with chronic illness management and marital satisfaction. Findings suggest that supporting patients\u27 healthy dietary habits may be particularly beneficial at reinforcing patients\u27 current efforts to manage their diet. Whereas, pressuring patients to change their behavior may be met with unintended interference with adherence. Additionally, the different findings between spouse diet-related persuasion and pressure suggest that spouse control has multiple facets warranting further research to examine their effectiveness within an illness context. This study contributed to the examination of potential moderators between spouse involvement and patient outcomes suggesting that one size does not fit all. For couples where the spouse reports eating a healthful diet more often, patients may feel discouraged by their spouses\u27 attempts to change their diet habits when spouses may not seem to be struggling in maintaining a healthy diet resulting in poorer patient dietary adherence

Fire Influence on Regional to Global Environments and Air Quality (FIREX‐AQ)

The NOAA/NASA Fire Influence on Regional to Global Environments and Air Quality (FIREX-AQ) experiment was a multi-agency, inter-disciplinary research effort to: (a) obtain detailed measurements of trace gas and aerosol emissions from wildfires and prescribed fires using aircraft, satellites and ground-based instruments, (b) make extensive suborbital remote sensing measurements of fire dynamics, (c) assess local, regional, and global modeling of fires, and (d) strengthen connections to observables on the ground such as fuels and fuel consumption and satellite products such as burned area and fire radiative power. From Boise, ID western wildfires were studied with the NASA DC-8 and two NOAA Twin Otter aircraft. The high-altitude NASA ER-2 was deployed from Palmdale, CA to observe some of these fires in conjunction with satellite overpasses and the other aircraft. Further research was conducted on three mobile laboratories and ground sites, and 17 different modeling forecast and analyses products for fire, fuels and air quality and climate implications. From Salina, KS the DC-8 investigated 87 smaller fires in the Southeast with remote and in-situ data collection. Sampling by all platforms was designed to measure emissions of trace gases and aerosols with multiple transects to capture the chemical transformation of these emissions and perform remote sensing observations of fire and smoke plumes under day and night conditions. The emissions were linked to fuels consumed and fire radiative power using orbital and suborbital remote sensing observations collected during overflights of the fires and smoke plumes and ground sampling of fuels