Elements for a pedagogical practice of children's play

Dada la importancia que se atribuye al juego en la vida del niño, tal vez una de las tareas fundamentales que debe afrontar el educador de la infancia es el como constituir el juego en elemento esencial de la educación del niño. En este sentido, los aportes extractados de las investigaciones de R. |. Zhukowvskaia, constituyen una valiosa herramienta para la realización de una práctica pedagógica del juego que lleve a conjugar óptimamente la motivación mayor del niño, con los objetivos fundamentales del preescolar.Given the importance attributed to play in the child's life, perhaps one of the fundamental tasks that the early childhood educator must face is how to make play an essential element of the child's education. In this sense, the contributions extracted from the investigations of R. |. Zhukowvskaia, constitute a valuable tool for the realization of a pedagogical practice of the game that leads to optimally combine the greater motivation of the child, with the fundamental goals of preschool.Modalidad Presencia

Educators Today

Una de las tareas fundamentales de la educadora Prees-colar comprometida realmente con su trabajo, debe ser el conocimiento y revisión crítica en forma permanente, de las diversas teorías y propuestas que a través del tiempo, desarrollan los pedagogos.One of the fundamental tasks of the Preschool educator truly committed to her work must be the permanent knowledge and critical review of the various theories and proposals that pedagogues develop over time.Modalidad Presencia

Reflections Magazine of the Faculty of Education. Volume 4 No. 7 December 1988

La Revista de la Facultad de Educación Preescolar de la Universidad Autónoma de Bucaramanga recibe para su publicación trabajos sobre Educación, Infancia, Formación de Docentes, Trabajo Comunitario, Psicología Infantil y temas afines.The Magazine of the Faculty of Preschool Education of the Autonomous University of Bucaramanga receives for its publication works on Education, Childhood, Teacher Training, Community Work, Child Psychology and related topics.Modalidad Presencia

Faculty of Preschool Education. Volume 4. No. 6 July 1988

Recurriendo en alguna medida a las modernas técnicas de diseño de medios impresos, damos un viraje a la Revista de la Facultad de Educación Pre-escolar canal fundamental de la vida universitaria, medio de proyección de nuestra institución y vía de recepción de los avances de la educación en el país pretendiendo con ello dar respuesta a un buen número de inquietudes y expectativas expresadas por alumnos y profesores en sondeo llevado a cabo sobre el particular.EDITORIAL. - NUESTRA FACULTAD. -EL ENRIQUECIMIENTO DEL JUEGO INFANTIL Y SU RELACION CON LA ACTIVIDAD PEDAGOGIGCA. - REFLEXIONES SOBRE EL NIÑO Y EL JUEGO. - EDUCACION ACTUAL. - LOS VAIVENES DE LA POLITICA SOCIAL DEL ESTADO: ELCASO DE LOS HOGARES INFANTILES DEL ICBF. - LA FORMACION DE LA AFECTIVIDAD. - Grandes educadores. - LAS CIENCIAS SOCIALES EN COLOMBIA. - CULTURALES Y EVENTO. - SEMINARIO TALLER EDUCACION PRE-ESCOLAR ICFES-UPTC. -EXPERIENCIAS PEDADOGICAS. -Resorting to some extent to modern print media design techniques, we give a turn to the Magazine of the Faculty of Pre-school Education, a fundamental channel of university life, a means of projection of our institution and a channel for receiving the advances of the education in the country, thereby trying to respond to a good number of concerns and expectations expressed by students and teachers in a survey carried out on the subject

Magazine of the Faculty of Education. Volume 2 No. 3 November 1986

Entre las acciones tendientes a mejorar cada día la formación de los educadores preescolares, la facultad ha considerado que su revista debe constituirse en el medio de la comunicación más eficaz entre los diferentes estamentos que se relacionan con la educación infantil.Presentación.- Facultad de Educación.- Nuestra facultad.- El niño.- Investigación en educación.- Educación sexual para el nivel pre-escolar.- Estudio del comportamiento agresivo.- Modelos pedagógicos y formación de maestros.- El circulo del tiempo y los maestros.- Grandes educadores.- Culturales y eventos.- Tercer congreso nacional de educación preescolar.- Eventos científicos.- Experiencias pedagógicas.- Experiencias didácticas.- Una experiencia con mis alumnas.- Bibliografía.-Among the actions aimed at improving the training of preschool educators every day, the faculty has considered that its magazine should become the most effective means of communication between the different levels that are related to early childhood education.Modalidad Presencia

Axicabtagene ciloleucel compared to tisagenlecleucel for the treatment of aggressive B-cell lymphoma

Axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel) are CD19-targeted chimeric antigen receptor (CAR) T cells approved for relapsed/refractory (R/R) large B-cell lymphoma (LBCL). We performed a retrospective study to evaluate safety and efficacy of axi-cel and tisa-cel outside the setting of a clinical trial. Data from consecutive patients with R/R LBCL who underwent apheresis for axi-cel or tisa-cel were retrospectively collected from 12 Spanish centers. A total of 307 patients underwent apheresis for axi-cel (n=152) and tisa-cel (n=155) from November 2018 to August 2021, of which 261 (85%) received a CAR T infusion (88% and 82%, respectively). Median time from apheresis to infusion was 41 days for axi-cel and 52 days for tisa-cel (P =0.006). None of the baseline characteristics were significantly different between both cohorts. Both cytokine release syndrome and neurologic events (NE) were more frequent in the axi-cel group (88% vs. 73%, P =0.003, and 42% vs. 16%, P <0.001, respectively). Infections in the first 6 months post-infusion were also more common in patients treated with axi-cel (38% vs. 25%, P =0.033). Non-relapse mortality was not significantly different between the axi-cel and tisa-cel groups (7% and 4%, respectively, P =0.298). With a median follow-up of 9.2 months, median PFS and OS were 5.9 and 3 months, and 13.9 and 11.2 months for axi-cel and tisa-cel, respectively. The 12-month PFS and OS for axi-cel and tisa-cel were 41% and 33% (P =0.195), 51% and 47% (P =0.191), respectively. Factors associated with lower OS in the multivariate analysis were increased lactate dehydrogenase, ECOG ≥2 and progressive disease before lympho-depletion. Safety and efficacy results in our real-world experience were comparable with those reported in the pivotal trials. Patients treated with axi-cel experienced more toxicity but similar non-relapse mortality compared with those receiving tisa-cel. Efficacy was not significantly different between both products

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Electroweak production of two jets in association with a Z boson in proton-proton collisions root s =13 TeV

A measurement of the electroweak (EW) production of two jets in association with a Z boson in proton-proton collisions at root s = 13 TeV is presented, based on data recorded in 2016 by the CMS experiment at the LHC corresponding to an integrated luminosity of 35.9 fb(-1). The measurement is performed in the lljj final state with l including electrons and muons, and the jets j corresponding to the quarks produced in the hard interaction. The measured cross section in a kinematic region defined by invariant masses m(ll) > 50 GeV, m(jj) > 120 GeV, and transverse momenta P-Tj > 25 GeV is sigma(EW) (lljj) = 534 +/- 20 (stat) fb (syst) fb, in agreement with leading-order standard model predictions. The final state is also used to perform a search for anomalous trilinear gauge couplings. No evidence is found and limits on anomalous trilinear gauge couplings associated with dimension-six operators are given in the framework of an effective field theory. The corresponding 95% confidence level intervals are -2.6 <cwww/Lambda(2) <2.6 TeV-2 and -8.4 <cw/Lambda(2) <10.1 TeV-2. The additional jet activity of events in a signal-enriched region is also studied, and the measurements are in agreement with predictions.Peer reviewe