Modelling last glacial cycle ice dynamics in the Alps

The European Alps, the cradle of pioneering glacial studies, are one of the regions where geological markers of past glaciations are most abundant and well-studied. Such conditions make the region ideal for testing numerical glacier models based on simplified ice flow physics against field-based reconstructions and vice versa.Here, we use the Parallel Ice Sheet Model (PISM) to model the entire last glacial cycle (120–0&thinsp;ka) in the Alps, using horizontal resolutions of 2 and 1&thinsp;km. Climate forcing is derived using two sources: present-day climate data from WorldClim and the ERA-Interim reanalysis; time-dependent temperature offsets from multiple palaeo-climate proxies. Among the latter, only the European Project for Ice Coring in Antarctica (EPICA) ice core record yields glaciation during marine oxygen isotope stages 4 (69–62&thinsp;ka) and 2 (34–18&thinsp;ka). This is spatially and temporally consistent with the geological reconstructions, while the other records used result in excessive early glacial cycle ice cover and a late Last Glacial Maximum. Despite the low variability of this Antarctic-based climate forcing, our simulation depicts a highly dynamic ice sheet, showing that Alpine glaciers may have advanced many times over the foreland during the last glacial cycle. Ice flow patterns during peak glaciation are largely governed by subglacial topography but include occasional transfluences through the mountain passes. Modelled maximum ice surface is on average 861&thinsp;m higher than observed trimline elevations in the upper Rhône Valley, yet our simulation predicts little erosion at high elevation due to cold-based ice. Finally, despite the uniform climate forcing, differences in glacier catchment hypsometry produce a time-transgressive Last Glacial Maximum advance, with some glaciers reaching their modelled maximum extent as early as 27&thinsp;ka and others as late as 21&thinsp;ka.</p

Operation of a Cherenkov counter with an ultraviolet photoionization detector

We have built and successfully operated a Cherenkov counter employing the far ultraviolet region of the spectrum to photoionize benzene in a proportional chamber. The operating conditions for such a chamber are described. The results of tests in a beam of pions are shown.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/23728/1/0000700.pd

Solar Neutrinos: Radiative Corrections in Neutrino-Electron Scattering Experiments

Radiative corrections to the electron recoil-energy spectra and to total cross sections are computed for neutrino-electron scattering by solar neutrinos. Radiative corrections change monotonically the electron recoil spectrum for incident \b8 neutrinos, with the relative probability of observing recoil electrons being reduced by about 4 \% at the highest electron energies. For $p-p$ and \be7 neutrinos, the recoil spectra are not affected significantly. Total cross sections for solar neutrino-electron scattering are reduced by about 2 \% compared to previously computed values. We also calculate the recoil spectra from $^{13}$N and $^{15}$O neutrinos including radiative corrections.Comment: 40 pages, uuencoded, Z-compress file

A liquid Xenon Positron Emission Tomograph for small animal imaging : first experimental results of a prototype cell

A detector using liquid Xenon (LXe) in the scintillation mode is studied for Positron Emission Tomography (PET) of small animals. Its specific design aims at taking full advantage of the Liquid Xenon scintillation properties. This paper reports on energy, time and spatial resolution capabilities of the first LXe prototype module equipped with a Position Sensitive Photo- Multiplier tube (PSPMT) operating in the VUV range (178 nm) and at 165 K. The experimental results show that such a LXe PET configuration might be a promising solution insensitive to any parallax effect.Comment: 34 pages, 18 pages, to appear in NIM

Pharmacologic IRE1/XBP1s Activation Confers Targeted ER Proteostasis Reprogramming

Activation of the IRE1/XBP1s signaling arm of the unfolded protein response (UPR) is a promising strategy to correct defects in endoplasmic reticulum (ER) proteostasis implicated in diverse diseases. However, no pharmacologic activators of this pathway identified to date are suitable for ER proteostasis remodeling through selective activation of IRE1/XBP1s signaling. Here, we use high-throughput screening to identify non-toxic compounds that induce ER proteostasis remodeling through IRE1/XBP1s activation. We employ transcriptional profiling to stringently confirm that our prioritized compounds selectively activate IRE1/XBP1s signaling without activating other cellular stress-responsive signaling pathways. Furthermore, we demonstrate that our compounds improve ER proteostasis of destabilized variants of amyloid precursor protein (APP) through an IRE1-dependent mechanism and reduce APP-associated mitochondrial toxicity in cellular models. These results establish highly selective IRE1/XBP1s activating compounds that can be widely employed to define the functional importance of IRE1/XBP1s activity for ER proteostasis regulation in the context of health and disease. [Figure not available: see fulltext.]

Design, Construction, Operation and Performance of a Hadron Blind Detector for the PHENIX Experiment

A Hadron Blind Detector (HBD) has been developed, constructed and successfully operated within the PHENIX detector at RHIC. The HBD is a Cherenkov detector operated with pure CF4. It has a 50 cm long radiator directly coupled in a window- less configuration to a readout element consisting of a triple GEM stack, with a CsI photocathode evaporated on the top surface of the top GEM and pad readout at the bottom of the stack. This paper gives a comprehensive account of the construction, operation and in-beam performance of the detector.Comment: 51 pages, 39 Figures, submitted to Nuclear Instruments and Method

The HERMES Dual-Radiator Ring Imaging Cerenkov Detector

The construction and use of a dual radiator Ring Imaging Cerenkov(RICH) detector is described. This instrument was developed for the HERMES experiment at DESY which emphasizes measurements of semi-inclusive deep-inelastic scattering. It provides particle identification for pions, kaons, and protons in the momentum range from 2 to 15 GeV, which is essential to these studies. The instrument uses two radiators, C4F10, a heavy fluorocarbon gas, and a wall of silica aerogel tiles. The use of aerogel in a RICH detector has only recently become possible with the development of clear, large homogeneous and hydrophobic aerogel. A lightweight mirror was constructed using a newly perfected technique to make resin-coated carbon-fiber surfaces of optical quality. The photon detector consists of 1934 photomultiplier tubes for each detector half, held in a soft steel matrix to provide shielding against the residual field of the main spectrometer magnet.Comment: 25 pages, 23 figure

The Identification of rDNA-ITS and Localization of heterochronic gene In Meloidogyne javanica

根结线虫是重要的植物内寄生线虫。本论文以同安农田采集的番茄病根中爪哇根结线虫为实验材料，对病根进行解剖，收集成虫、二期幼虫和卵块。通过对根结线虫胚胎发育和生活史中各期虫体形态的观察，进一步定种为爪哇根结线虫。通过感染室内土培番茄，使得爪哇根结线虫在实验室得到进一步的扩大培养，为后续实验的进行提供了材料。利用rRNA基因间隔序列的保守性引物对来自不同宿主的爪哇根结线虫和南方根结线虫的rDNA-ITS1和rDNA-ITS2序列进行了扩增，与Genebank中根结线虫的ITS1序列在clustalX软件中进行了分析，构建系统发生树和遗传距离矩阵。分析可知，来源于番茄根内和蒲公英根内的爪哇根结线虫rD...Root-knot nematodes are important endo-parasites in economic plants. The roots of tomatoes infected with M. javanica were got from the field of Tong’an rural area and roots were dissected.The egg masses, pre-parasitic juveniles and female adults of M. javanica were collected in the lab.The embryo development and different stages of life cycle of root-knot nematode were observed. In order to obtain...学位：理学硕士院系专业：生命科学学院生物学系_动物学学号：20032601

Model Independent Determination of the Solar Neutrino Spectrum with and without MSW

Besides the opportunity for discovering new neutrino physics, solar neutrino measurements provide a sensitive probe of the solar interior, and thus a rigorous test of solar model predictions. We present model independent determinations of the neutrino spectrum by using relevant flux components as free parameters subject only to the luminosity constraint. (1) Without the Mikheyev-Smirnov-Wolfenstein (MSW) effect, the best fit for the combined data is poor. Furthermore, the data indicate a severe suppression of the $^7$Be flux relative to the $^8$B, contradicting both standard and nonstandard solar models in general; the $pp$ flux takes its maximum value allowed by the luminosity constraint. This pathology consistently appears even if we ignore any one of the three data. (2) In the presence of the two-flavor MSW effect, the current constraint on the initial $^8$B flux is weak, but consistent with the SSM and sufficient to exclude nonstandard models with small $^8$B fluxes. No meaningful constraint is obtained for the other fluxes. In the future, even allowing MSW, the $^8$B and $^7$Be fluxes can be determined at the $\pm$(15 -- 20)\% level, making competing solar models distinguishable. We emphasize that the neutral current sensitivity for $^7$Be neutrinos in BOREXINO, HELLAZ, and HERON is essential for determining the initial fluxes. The constraints on the MSW parameters in the model independent analysis are also discussed.Comment: Revtex 3.0, 61 pages including 23 figures, uuencoded ps file attached. Easy way: compressed ps file of entire paper in landscape format available by anonymous ftp://upenn5.hep.upenn.edu/pub/hata/papers/model_ind.ps.