Worlds apart: Pictorial semantics in the left and right cerebral hemispheres

The dominant view in neuropsychology fails to consider that the hemispheric "functional division of labor" in terms of language versus non-language reflects but one dimension of hemispheric differences. That is, specialization of language in the left hemisphere and of spatial orientation in the right represent only specific aspects of the general underlying hemispheric meaning systems. Indeed, we have found that there can be two full-blown meaning systems, one in the left and one in the right, which can operate separately and simultaneously in the normal brain.

Regional differentiation of neuron morphology in human left and right hippocampus: Comparing normal to schizophrenia

Regional differentiation based on size, form, and orientation angle of the soma of individual neurons in human post-mortem hippocampus was determined through correlations between pairs of hippocampal subfields in each side separately. The neurons were previously measured on a computer. In the normal cases, a left-right asymmetrical pattern of regional differentiation based on soma size emerged, while for form and orientation angle, the patterns appeared symmetrical. In schizophrenia, regional soma size, form, and orientation variability were expressed largely symmetrically. Regional correlations based on neuronal density revealed an asymmetrical hemispheric pattern in the normal cases versus a nearly symmetrical pattern in schizophrenia. Taken together, the inter-regional correlations favor a hippocampal landscape that deviates in each side from connectivity based on the canonical trisynaptic hippocampal circuitry. It is proposed that during morphogenesis, rudimentary inter-regional networks are formed through specific interactions between regional neurons; these networks are present in the adult hippocampus and may be vulnerable in brain diseases

The case for a relationship between human memory, hippocampus and corpus callosum

Unilateral brain damage which includes the hippocampus leads to memory impairments consistent with hemispheric specialization on the same side. Damage to the corpus callosum, the major connecting pathway between the left and right hemispheres, also leads to memory impairments. This suggests both hemispheric specialization on the hippocampal level and a critical role for the corpus callosum in memory functions. A complete hippocampal formation is present on either side of the brain but traditionally only one is studied. However, a comparison between the neuronal populations in the hippocampus on both sides revealed asymmetry in connectivity among hippocampal subfields. The profile of memory impairments of commissurotomy (‘split-brain’) patients is described. The results are discussed in terms of a relationship between hippocampus and corpus callosum in humans. As hemispheric specialization evolved, inter-hippocampal connections became less important and the corpus callosum became prominent in memory functions

Quantitative morphology of human hippocampus early neuron development

Background: Previous findings in adults revealed significant hemispheric asymmetry in size of neuronal somata in hippocampal subfield CA2 (the “resistant sector”) with no age-related changes. Paucity of quantitative data on the developmental status of these “protected” neurons has led to the investigation of their morphology in comparison to neurons in adjacent subfield CA3, bilaterally. Methods: Bilateral coronal sections from postmortem hippocampus, 24 and 76 weeks postmenstrual age (gestational age plus postnatal age) were studied. The neurons were digitized and measured on a computer. Results: Soma size correlated positively and significantly with age in CA2 and CA3, bilaterally. CA2 somata were significantly larger (left 34%, right 32%) than adjacent CA3 somata. Variability in soma form or size increased appreciably with age, in both subfields, bilaterally, while variability in soma orientation was weakly correlated with brain growth. Conclusions: The results suggest that in early development there are similarities in hemispheric growth patterns in CA2 and CA3. Large CA2 soma size implies axonal connectivity to distantly located targets very early in development. The results have functional implications, including memory, to brain developmen

A view of the world from a split-brain perspective

The extent to which observed behavior in the complete commissurotomy patients is supported by only one hemisphere would depend on individual differences interacting with a variety of factors such as genetics, intelligence, and so on. The lesson imparted here is that there is sufficient functional redundancy in the neocortex so that the capacity to maintain a wide range of abilities is within the control of one hemisphere. And, yet, as seen in what is missing in the patients' behavior, one hemisphere is not quite enough. Nature seems to have intended that the two hemispheres complement each other, that the full range of human behavior be best accomplished through interaction between the left and right hemispheres

Hemi-field memory for attractiveness

In order to determine whether or not facial attractiveness plays a role in hemispheric facial memory, 35 right-handed participants first assigned attractiveness ratings to faces and then performed a recognition test on those faces in the left visual half-field (LVF) and right visual half-field (RVF). We found significant interactions between the experimental factors and visual half- field. There were significant differences in the extreme ends of the rating scale, that is, the very unattractive versus the very attractive faces: Female participants remembered very attractive faces of both women and men, with memory being superior in the RVF than in the LVF. In contrast, the male participants remembered very unattractive faces of both women and men; RVF memory was better than the LVF for women faces while for men faces memory was superior in the LVF. The interactions with visual half-field suggest that hemispheric biases in remembering faces are influenced by degree of attractiveness

The face, beauty, and symmetry: Perceiving asymmetry in beautiful faces

The relationship between bilateral facial symmetry and beauty remains to be clarified. Here, straight head-on photographs of “beautiful” faces from the collections of professional modeling agencies were selected. First, beauty ratings were obtained for these faces. Then, the authors created symmetrical left-left and right-right composites of the beautiful faces and asked a new group of subjects to choose the most attractive pair member. “Same” responses were allowed. No difference between the left-left and right-right composites was revealed but significant differences were obtained between “same” and the left-left or right-right. These results show that subjects detected asymmetry in beauty and suggest that very beautiful faces can be functionally asymmetrical

Observations on the relationship between verbal explicit and implicit memory and neuronal density in the left and right hippocampus in temporal lobectomy patients.

The relationship between neuronal density and verbal memory in left and right hippocampal subfields was investigated in patients who underwent surgery for alleviation of temporal lobe epilepsy. The surgery consisted of unilateral partial removal of the hippocampus along with the anterior temporal lobe and amygdala. Study 1 looked at post-surgical explicit versus implicit verbal memory for lists of words while Study 2 looked at pre- and post-surgical explicit memory for word pairs. Left subfield CA1 appeared to be the most consistently involved in explicit and implicit memory. The results of the two studies confirm presence of hemispheric asymmetry in verbal memory. The notion that hippocampal control of memory is most apparent in post-surgical performance is discussed

Low-Density Code-Domain NOMA: Better Be Regular

A closed-form analytical expression is derived for the limiting empirical squared singular value density of a spreading (signature) matrix corresponding to sparse low-density code-domain (LDCD) non-orthogonal multiple-access (NOMA) with regular random user-resource allocation. The derivation relies on associating the spreading matrix with the adjacency matrix of a large semiregular bipartite graph. For a simple repetition-based sparse spreading scheme, the result directly follows from a rigorous analysis of spectral measures of infinite graphs. Turning to random (sparse) binary spreading, we harness the cavity method from statistical physics, and show that the limiting spectral density coincides in both cases. Next, we use this density to compute the normalized input-output mutual information of the underlying vector channel in the large-system limit. The latter may be interpreted as the achievable total throughput per dimension with optimum processing in a corresponding multiple-access channel setting or, alternatively, in a fully-symmetric broadcast channel setting with full decoding capabilities at each receiver. Surprisingly, the total throughput of regular LDCD-NOMA is found to be not only superior to that achieved with irregular user-resource allocation, but also to the total throughput of dense randomly-spread NOMA, for which optimum processing is computationally intractable. In contrast, the superior performance of regular LDCD-NOMA can be potentially achieved with a feasible message-passing algorithm. This observation may advocate employing regular, rather than irregular, LDCD-NOMA in 5G cellular physical layer design.Comment: Accepted for publication in the IEEE International Symposium on Information Theory (ISIT), June 201

Self recognition and social awareness in the deconnected minor hemisphere

Two patients with cerebral commissurotomy were tested with visual input lateralized to left or right half of the visual field by an opaque hemifield screen set in the focal plane of an optical system mounted on a scleral contact lens which allowed prolonged exposure and ocular scanning of complex visual arrays. Key personal and affect-laden stimuli along with items for assessing general social knowledgability were presented among neutral unknowns in visual arrays with 4-9 choices. Selective manual and associated emotional responses obtained from the minor hemisphere to pictures of subject's self, relatives, pets and belongings, and of public, historical and religious figures and personalities from the entertainment world revealed a characteristic social, political, personal and self-awareness comparable roughly to that of the major hemisphere of the same subject