Doctor of Philosophy

dissertationDespite being half of the population, a dearth of women serve in elected office across the United States and in all levels of government. When women do run for public office, research shows that some type of community participation often serves as a pathway to elected office. This study examines one type of community participation, voluntary neighborhood governance. It uses as a case study Salt Lake City, which for at least 25 years has supported neighborhood governance through its well-organized system of place-based institutions known as community councils. Using evidence from document review, interviews, and observation, the study demonstrates how community councils are situated within Salt Lake City's political systems, and the ways in which individuals are transformed through engagement with the councils. It finds that under certain combinations of predilections and conditions, community council participation politically empowers women specifically, women who ran for political office were overrepresented in their incorporation of community council participation as a portion of their pathway to elected public service. Empowerment outcomes, however, were diminished by conditions such as community council role confusion and sentiments about "right" and "wrong" types of participation

Pancreatic Resections for Advanced M1-Pancreatic Carcinoma: The Value of Synchronous Metastasectomy

Background. For M1 pancreatic adenocarcinomas pancreatic resection is usually not indicated. However, in highly selected patients synchronous metastasectomy may be appropriate together with pancreatic resection when operative morbidity is low. Materials and Methods. From January 1, 2004 to December, 2007 a total of 20 patients with pancreatic malignancies were retrospectively evaluated who underwent pancreatic surgery with synchronous resection of hepatic, adjacent organ, or peritoneal metastases for proven UICC stage IV periampullary cancer of the pancreas. Perioperative as well as clinicopathological parameters were evaluated. Results. There were 20 patients (9 men, 11 women; mean age 58 years) identified. The primary tumor was located in the pancreatic head (n = 9, 45%), in pancreatic tail (n = 9, 45%), and in the papilla Vateri (n = 2, 10%). Metastases were located in the liver (n = 14, 70%), peritoneum (n = 5, 25%), and omentum majus (n = 2, 10%). Lymphnode metastases were present in 16 patients (80%). All patients received resection of their tumors together with metastasectomy. Pylorus preserving duodenopancreatectomy was performed in 8 patients, distal pancreatectomy in 8, duodenopancreatectomy in 2, and total pancreatectomy in 2. Morbidity was 45% and there was no perioperative mortality. Median postoperative survival was 10.7 months (2.6–37.7 months) which was not significantly different from a matched-pair group of patients who underwent pancreatic resection for UICC adenocarcinoma of the pancreas (median survival 15.6 months; P = .1). Conclusion. Pancreatic resection for M1 periampullary cancer of the pancreas can be performed safely in well-selected patients. However, indication for surgery has to be made on an individual basis

Past, Present and Potential Future Prion Disease Treatment Strategies

The prion diseases are rare and invariably fatal neurodegenerative diseases characterized by a unique, protein‐only pathogenesis. Mechanistically, the prion diseases result from the coerced conversion of a protease‐sensitive form of the cellular prion protein (PrPC) into a protease‐resistant infectious form (PrPres). This chapter reviews the past, present, and potentially future prion disease treatment strategies. This chapter begins with an introduction to prion diseases, the misfolding of prion proteins and what is known about this process, and then proceeds to discuss approaches for treatments. Regarding approaches to treat prion diseases, we discuss (1) small molecule inhibitors, (2) antiprion protein antibodies, (3) prion gene disruption, (4) targeting of the unfolded protein response, and (5) heterologous prion proteins. We elaborate on using heterologous prion proteins to treat prion diseases, as this is an area that we are pursuing. The chapter ends with thoughts on the future direction of prion disease treatment strategies and how these strategies might be applicable to other neurodegenerative diseases involving protein misfolding. The increasing awareness of the role of protein misfolding in many neurodegenerative processes makes the development of an effective treatment strategy for prion diseases a high priority

Neurobehavioral Testing in Prion Disease Studies

The prion diseases are neurodegenerative diseases characterized by progressive neurocognitive decline and terminal dementia. In this review, we will discuss the role of neurobehavioral testing in mammalian prion disease model systems, including (1) a review of the clinical phenotype of the major prion diseases in natural disease, (2) an evidence-based summary of the benefits and shortcomings of commonly used behavioral assays, and (3) a review of the neurobehavioral testing in rodent prion models. Based upon this review, and in light of the established importance of model systems in studies of prion pathogenesis and the proven role of behavioral testing in nonprion disease neurodegenerative diseases, it is vital that prion researchers consider the clinical consequences of prion infection so as to maximize the impact of their work

The complex gas kinematics in the nucleus of the Seyfert 2 galaxy NGC 1386: rotation, outflows and inflows

We present optical integral field spectroscopy of the circum-nuclear gas of the Seyfert 2 galaxy NGC 1386. The data cover the central 7$^{\prime\prime} \times 9^{\prime\prime}$ (530 $\times$ 680 pc) at a spatial resolution of 0.9" (68 pc), and the spectral range 5700-7000 \AA\ at a resolution of 66 km s$^{-1}$. The line emission is dominated by a bright central component, with two lobes extending $\approx$ 3$^{\prime\prime}$ north and south of the nucleus. We identify three main kinematic components. The first has low velocity dispersion ($\bar \sigma \approx$ 90 km s$^{-1}$), extends over the whole field-of-view, and has a velocity field consistent with gas rotating in the galaxy disk. We interpret the lobes as resulting from photoionization of disk gas in regions where the AGN radiation cones intercept the disk. The second has higher velocity dispersion ($\bar \sigma \approx$ 200 km s$^{-1}$) and is observed in the inner 150 pc around the continuum peak. This component is double peaked, with redshifted and blueshifted components separated by $\approx$ 500 km s$^{-1}$. Together with previous HST imaging, these features suggest the presence of a bipolar outflow for which we estimate a mass outflow rate of $\mathrm{\dot M} \gtrsim$ 0.1 M$_{\odot}$ yr$^{-1}$. The third component is revealed by velocity residuals associated with enhanced velocity dispersion and suggests that outflow and/or rotation is occurring approximately in the equatorial plane of the torus. A second system of velocity residuals may indicate the presence of streaming motions along dusty spirals in the disk.Comment: 24 pages, 16 figures, 3 tables, interesting results, accepted for publication in Ap

Probe-configuration dependent dephasing in a mesoscopic interferometer

Dephasing in a ballistic four-terminal Aharonov-Bohm geometry due to charge and voltage fluctuations is investigated. Treating two terminals as voltage probes, we find a strong dependence of the dephasing rate on the probe configuration in agreement with a recent experiment by Kobayashi et al. (J. Phys. Soc. Jpn. 71, 2094 (2002)). Voltage fluctuations in the measurement circuit are shown to be the source of the configuration dependence.Comment: 4 pages, 3 figure

Probe-Configuration-Dependent Decoherence in an Aharonov-Bohm Ring

We have measured transport through mesoscopic Aharonov-Bohm (AB) rings with two different four-terminal configurations. While the amplitude and the phase of the AB oscillations are well explained within the framework of the Landaur-B\"uttiker formalism, it is found that the probe configuration strongly affects the coherence time of the electrons, i.e., the decoherence is much reduced in the configuration of so-called nonlocal resistance. This result should provide an important clue in clarifying the mechanism of quantum decoherence in solids.Comment: 4 pages, 4 figures, RevTe