Interaction between integrin α9β1 and vascular cell adhesion molecule-1 (VCAM-1) inhibits neutrophil apoptosis

According to the prevailing paradigm, neutrophils are short-lived cells that undergo spontaneous apoptosis within 24 hours of their release from the bone marrow. However, neutrophil survival can be significantly prolonged within inflamed tissue by cytokines, inflammatory mediators, and hypoxia. During screening experiments aimed at identifying the effect of the adhesive microenvironment on neutrophil survival, we found that VCAM-1 (CD106) was able to delay both spontaneous and Fas-induced apoptosis. VCAM-1-mediated survival was as efficient as that induced by the cytokine IFN-β and provided an additive, increased delay in apoptosis when given in combination with IFN-β. VCAM-1 delivered its antiapoptotic effect through binding the integrin α9β1. The α9β 1 signaling pathway shares significant features with the IFN-β survival signaling pathway, requiring PI3 kinase, NF-κB activation, as well as de novo protein synthesis, but the kinetics of NF-κB activation by VCAM-1 were slower and more sustained compared with IFN-β. This study demonstrates a novel functional role for α9β1 in neutrophil biology and suggests that adhesive signaling pathways provide an important extrinsic checkpoint for the resolution of inflammatory responses in tissues

Performing resistance : sport and Irish Republican identity in internment camps and prisons

Under Creative Commons 4.0 (CC BY-NC-ND 4.0)Sport was an integral part of life in camps during the twentieth century, even in Nazi concentrations camps or in the Soviet Gulag. Traditionally perceived as a symbol of equality, play, and peacefulness, sport under such unexpected circumstances irritates most observers, back then and today. This volume studies the irritating fact of sport in penal and internment camps as an important insight into the history of camps. The authors enquire into case studies of sport being played in different forms of camps around the globe and throughout the twentieth century. They challenge our understanding of camps, question the dichotomy of insiders and outsiders, inner-camp hierarchies, and the everyday experience of violence. This fresh perspective complements the existing camp studies and gives way for the subjectivity of camp inmates and their action