Stochastic Downsampling for Cost-Adjustable Inference and Improved Regularization in Convolutional Networks

It is desirable to train convolutional networks (CNNs) to run more efficiently during inference. In many cases however, the computational budget that the system has for inference cannot be known beforehand during training, or the inference budget is dependent on the changing real-time resource availability. Thus, it is inadequate to train just inference-efficient CNNs, whose inference costs are not adjustable and cannot adapt to varied inference budgets. We propose a novel approach for cost-adjustable inference in CNNs - Stochastic Downsampling Point (SDPoint). During training, SDPoint applies feature map downsampling to a random point in the layer hierarchy, with a random downsampling ratio. The different stochastic downsampling configurations known as SDPoint instances (of the same model) have computational costs different from each other, while being trained to minimize the same prediction loss. Sharing network parameters across different instances provides significant regularization boost. During inference, one may handpick a SDPoint instance that best fits the inference budget. The effectiveness of SDPoint, as both a cost-adjustable inference approach and a regularizer, is validated through extensive experiments on image classification

Unique Transcriptional Profile of Sustained Ligand-Activated Preconditioning in Pre- and Post-Ischemic Myocardium

BACKGROUND: Opioidergic SLP (sustained ligand-activated preconditioning) induced by 3–5 days of opioid receptor (OR) agonism induces persistent protection against ischemia-reperfusion (I-R) injury in young and aged hearts, and is mechanistically distinct from conventional preconditioning responses. We thus applied unbiased gene-array interrogation to identify molecular effects of SLP in pre- and post-ischemic myocardium. METHODOLOGY/PRINCIPAL FINDINGS: Male C57Bl/6 mice were implanted with 75 mg morphine or placebo pellets for 5 days. Resultant SLP did not modify cardiac function, and markedly reduced dysfunction and injury in perfused hearts subjected to 25 min ischemia/45 min reperfusion. Microarray analysis identified 14 up- and 86 down-regulated genes in normoxic hearts from SLP mice (≥1.3-fold change, FDR≤5%). Induced genes encoded sarcomeric/contractile proteins (Myh7, Mybpc3,Myom2,Des), natriuretic peptides (Nppa,Nppb) and stress-signaling elements (Csda,Ptgds). Highly repressed genes primarily encoded chemokines (Ccl2,Ccl4,Ccl7,Ccl9,Ccl13,Ccl3l3,Cxcl3), cytokines (Il1b,Il6,Tnf) and other proteins involved in inflammation/immunity (C3,Cd74,Cd83, Cd86,Hla-dbq1,Hla-drb1,Saa1,Selp,Serpina3), together with endoplasmic stress proteins (known: Dnajb1,Herpud1,Socs3; putative: Il6, Gadd45g,Rcan1) and transcriptional controllers (Egr2,Egr3, Fos,Hmox1,Nfkbid). Biological themes modified thus related to inflammation/immunity, together with cellular/cardiovascular movement and development. SLP also modified the transcriptional response to I-R (46 genes uniquely altered post-ischemia), which may influence later infarction/remodeling. This included up-regulated determinants of cellular resistance to oxidant (Mgst3,Gstm1,Gstm2) and other forms of stress (Xirp1,Ankrd1,Clu), and repression of stress-response genes (Hspa1a,Hspd1,Hsp90aa,Hsph1,Serpinh1) and Txnip. CONCLUSIONS: Protection via SLP is associated with transcriptional repression of inflammation/immunity, up-regulation of sarcomeric elements and natriuretic peptides, and modulation of cell stress, growth and development, while conventional protective molecules are unaltered

Retrieving fin-de-siècle women poets: the transformative myths, fragments and voices of Webster, Blind and Levy

The critical recuperation of late nineteenth-century women poets, most still waiting in the margins of the literary canon, has owed significantly to the renovated interest and study of the poetical works of Augusta Webster, Mathilde Blind and Amy Levy (1860-90) by the postmodern reader. One of the reasons for this ‘salvage’ may be that they represent and embody the profound and extraordinary changes encompassing the British fin-de-siècle, in which the transition from the Victorians to the Moderns implied the transformation or reconfiguration of certain myths or (hi)stories and the critical re-use or ‘recycling’ of major literary forms. If, for Webster and Blind, involvement in radical politics (namely, feminism and socialism) certainly implied a stance as outsiders, Blind and Levy were even more set apart by their foreignness, with Levy’s different religion and sexuality increasing the distance even further. With recourse to close reading and cultural critique, this paper will analyse how these three women poets re-use fragments (‘verbal ruins’) of national and international history, as well as classic myth, in order to question and transform the images and representations of man and woman in their respective connections with the world. It will demonstrate that while Webster’s poetry (Dramatic Studies of 1866 and Portraits of 1870) is firmly grounded on social demands and the exploration and dramatization of the nature of female experience, Blind’s epic and dramatic verse (The Ascent of Man of 1889 and Dramas in Miniature of 1891) creates new myths of human destiny, reclaiming the Poet’s role as the singer of the age’s scientific deeds, and Levy’s lyrics (Xantippe of 1881 and A Minor Poet of 1884) signal the New Woman poet’s role as victim of the pressures of emancipation. With the support of critics as Isobel Armstrong, Helen Groth and Angela Leighton, the paper will furthermore discuss the way in which these poets explore the selves that women inherit and create and the languages that re-define them, often through the expansive, public forms of dramatic and narrative verse; through these hybrid and fragmentary forms, Webster, Blind and Levy literally give voice to unspeakable feelings and situations, in which the anomalous and marginal are made central.info:eu-repo/semantics/acceptedVersio

Availability of humic nitrogen to phytoplankton

The chemical, physical, and biological factors affecting the bioavailability of humic nitrogen (N) to coastal phytoplankton were examined. Historically, humic substances have largely been considered biologically refractory, and humic-N is though to be unavailable biologically without prior oxidation via photochemical cleavage or remineralization by bacteria. This is due in part to the high aromaticity and low N content of humic substances. This dissertation investigates whether these assumptions are valid, and whether humic substances may be a more important source of N to the coastal phytoplankton community than previously believed. The research consisted of four main parts. First, changes in the structure and N content of humic substances were monitored by forming humics in the laboratory and following the changes in structure and chemical composition as they aged. It was found that as humics age, they become more aliphatic and fulvic-like. It was also determined that the commonly used XAD-8 extraction technique may underestimate the N content of aquatic humics by stripping ammonium (NH4+) from the humic structure. Second, whether or not this underestimation of humic-N has an effect on previously reported rates of photochemical N liberation from humic compounds was investigated. It was found that while the potential for the underestimation of photochemical release exists, previously reported rates are close to correct, largely due to physical and chemical interactions of humic substances with the surrounding environment. Third, the bioavailability of humic-N was examined using a suite of coastal phytoplankton strains. In short, all coastal strains exposed to humic substances could take up humic-N in short-term incubations; an open ocean strain tested did not take up humic-N. Furthermore, younger humics appeared to be more labile than those aged for time periods greater than three months. Finally, the significance of the salinity-mediated release was investigated and found to be a potentially important transport mechanism of NH4 + to the mid-saline regions of the estuary. In conclusion, the combination of chemical, physical, and biological processes occurring in the estuarine and coastal ecosystems suggests that humic substances are highly dynamic, biologically active compounds and not the biologically recalcitrant molecules portrayed in current literature

Incorporating Human Readiness Levels at Sandia National Laboratories

Since 2010, the concept of human readiness levels has been under development as a possible supplement to the existing technology readiness level (TRL) scale. The intent is to provide a mechanism to address safety and performance risks associated with the human component in a system that parallels the TRL structure already familiar to the systems engineering community. Sandia National Laboratories in Albuquerque, New Mexico, initiated a study in 2015 to evaluate options to incorporate human readiness planning for Sandia processes and products. The study team has collected the majority of baseline assessment data and has conducted interviews to understand staff perceptions of four different options for human readiness planning. Preliminary results suggest that all four options may have a vital role, depending on the type of work performed and the phase of product development. Upon completion of data collection, the utility of identified solutions will be assessed in one or more test cases

Impact of Economic, Social, And Environmental Factors on Electric Vehicle Adoption: A Review

Electric vehicles (EVs) represent a transformative innovation in the automotive industry, offering a promising solution to environmental challenges. This paper examines the complex interplay of economic, social, and environmental factors that influence consumers' decisions to adopt EVs. Economic factors, such as initial purchase price and operating costs, play a crucial role in adoption. Research suggests that as EV prices become more competitive and operational expenses decline, adoption rates will accelerate. Social factors, including peer influence and perceptions of EV performance, reliability, and convenience, also shape consumer attitudes and preferences. Environmental considerations, including the imperative to mitigate greenhouse gas emissions and reduce air pollution, drive the adoption of EVs. This review synthesizes existing literature on the impact of economic, social, and environmental factors on EV adoption, providing valuable insights for policymakers, industry stakeholders, and researchers. By elucidating the complex dynamics that influence consumer behavior, this study contributes to the ongoing discourse on sustainable mobility and the transition towards a greener transportation ecosystem