80 research outputs found
Phase properties of the superposition of squeezed and displaced number states
We show that a nonlinear asymmetric directional coupler composed of a linear
waveguide and a nonlinear waveguide operating by nondegenerate parametric
amplification is an effective source of single-mode squeezed light. This is has
been demonstrated, under certain conditions and for specific modes, for
incident coherent beams in terms of the quasiprobability functions,
photon-number distribution and phase distribution.Comment: 17 pages, 4 figure
Generation of squeezed light in a nonlinear asymmetric directional coupler
We show that a nonlinear asymmetric directional coupler composed of a linear
waveguide and a nonlinear waveguide operating by nondegenerate parametric
amplification is an effective source of single-mode squeezed light. This is has
been demonstrated, under certain conditions and for specific modes, for
incident coherent beams in terms of the quasiprobability functions,
photon-number distribution and phase distribution.Comment: 19 pages, 5 figure
The effects of aging of scientists on their publication and citation patterns
The average age at which U.S. researchers get their first grant from NIH has
increased from 34.3 in 1970, to 41.7 in 2004. These data raise the crucial
question of the effects of aging on the scientific creativity and productivity
of researchers. Those who worry about the aging of scientists usually believe
that the younger they are the more creative and productive they will be. Using
a large population of 13,680 university professors in Quebec, we show that,
while scientific productivity rises sharply between 28 and 40, it increases at
a slower pace between 41 and 50 and stabilizes afterward until retirement for
the most active researchers. The average scientific impact per paper decreases
linearly until 50-55 years old, but the average number of papers in highly
cited journals and among highly cited papers rises continuously until
retirement. Our results clearly show for the first time the natural history of
the scientific productivity of scientists over their entire career and bring to
light the fact that researchers over 55 still contribute significantly to the
scientific community by producing high impact papers.Comment: 12 pages, 4 figure
The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia.
RATIONALE: The NEWMEDS initiative (Novel Methods leading to New Medications in Depression and Schizophrenia, http://www.newmeds-europe.com ) is a large industrial-academic collaborative project aimed at developing new methods for drug discovery for schizophrenia. As part of this project, Work package 2 (WP02) has developed and validated a comprehensive battery of novel touchscreen tasks for rats and mice for assessing cognitive domains relevant to schizophrenia. OBJECTIVES: This article provides a review of the touchscreen battery of tasks for rats and mice for assessing cognitive domains relevant to schizophrenia and highlights validation data presented in several primary articles in this issue and elsewhere. METHODS: The battery consists of the five-choice serial reaction time task and a novel rodent continuous performance task for measuring attention, a three-stimulus visual reversal and the serial visual reversal task for measuring cognitive flexibility, novel non-matching to sample-based tasks for measuring spatial working memory and paired-associates learning for measuring long-term memory. RESULTS: The rodent (i.e. both rats and mice) touchscreen operant chamber and battery has high translational value across species due to its emphasis on construct as well as face validity. In addition, it offers cognitive profiling of models of diseases with cognitive symptoms (not limited to schizophrenia) through a battery approach, whereby multiple cognitive constructs can be measured using the same apparatus, enabling comparisons of performance across tasks. CONCLUSION: This battery of tests constitutes an extensive tool package for both model characterisation and pre-clinical drug discovery.This work was supported by the Innovative Medicine Initiative Joint Undertaking under grant agreement no. 115008 of which resources are composed of EFPIA in-kind contribution and financial contribution from the European Union’s Seventh Framework Programme (FP7/2007-2013). The authors thank Charlotte Oomen for valuable comments on the manuscript.This is the author accepted manuscript. The final version is available from Springer via http://dx.doi.org/10.1007/s00213-015-4007-
A Systematic Failing of Current Density Functionals: Overestimation of Two-Center Three-Electron Bonding Energies
Between history and values: A study on the nature of interpretation in international law
My thesis discusses the place of evaluative judgements in the interpretation of general international law. It concentrates on two questions. First, whether it is possible to interpret international legal practices without making an evaluative judgement about the point or value that provides the best justification of these practices. Second, whether the use of evaluative judgements in international legal interpretation threatens to undermine the objectivity of international law, the neutrality of international lawyers or the consensual and voluntary basis of the international legal system. I answer both questions in the negative. As regards the first, I argue that international legal practice has an interpretive structure, which combines appeals to the history of international practice with appeals to the principles and values that these practices are best understood as promoting. This interpretive structure is apparent not only in the claims of international lawyers about particular rules of international law (here I use the rule of estoppel as an example) but also in the most basic intuitions of international theorists about the theory and sources of general international law. I then argue that some popular concerns to the effect that the exercise of evaluation in the interpretation of international law will undermine the coherence or the usefulness of the discipline are generally unwarranted. The fact that international legal practice has an interpretive structure does not entail that propositions of international law are only subjectively true, that the interpreter enjoys license to manipulate their meaning for self-serving purposes, or that international law will collapse under the weight of irresolvable disagreements, divisions and conflicts about its proper interpretation
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