The Hubble Constant from Observations of the Brightest Red Giant Stars in a Virgo-Cluster Galaxy

The Virgo and Fornax clusters of galaxies play central roles in determining the Hubble constant H_0. A powerful and direct way of establishing distances for elliptical galaxies is to use the luminosities of the brightest red-giant stars (the TRGB luminosity, at M_I = -4.2). Here we report the direct observation of the TRGB stars in a dwarf elliptical galaxy in the Virgo cluster. We find its distance to be 15.7 +- 1.5 Megaparsecs, from which we estimate a Hubble constant of H_0 = 77 +- 8 km/s/Mpc. Under the assumption of a low-density Universe with the simplest cosmology, the age of the Universe is no more than 12-13 billion years.Comment: 12 pages, LaTeX, with 2 postscript figures; in press for Nature, July 199

The early-type dwarf galaxy population of the Centaurus cluster

We present a photometric study of the early-type dwarf galaxy population of the Centaurus cluster, aiming at investigating the galaxy luminosity function (LF) and galaxy scaling relations down to the regime of galaxies with M_V~-10 mag. On deep VLT/FORS1 V- and I-band images of the central part of the cluster, we identify cluster dwarf-galaxy candidates using both morphological and surface brightness selection criteria. Photometric and structural parameters of the candidates are derived from analysis of their surface brightness profiles. Fundamental scaling relations, such as the colour-magnitude and the magnitude-surface brightness relation, are used to distinguish the cluster from the background. We find a flat LF with a slope of \alpha = -1.14 \pm 0.12 for M_V>-14 mag, when fitting a power law to the completeness-corrected galaxy number counts. When plotting the central surface brightness of a Sersic model vs. the galaxy magnitude, we find a continuous relation for magnitudes -20<M_V<-10 mag, with only the brightest core galaxies deviating from this relation, in agreement with previous studies of other clusters. In a size-luminosity diagram of early-type galaxies from a range of environments, we observe that R_eff slowly decreases with decreasing luminosity for -21<M_V<-13 mag and decreases more rapidly at fainter magnitudes. This trend continues to the ultra-faint Local Group dwarf galaxies (M_V~-4 mag). The continuous central surface brightness vs. absolute magnitude relation and the smooth relation in the size-luminosity diagram over a wide range of magnitudes are consistent with the interpretation of dwarf galaxies and more massive elliptical galaxies being one family of objects with gradually changing structural properties. The most massive core galaxies and the rare cE galaxies are the only exceptions.Comment: 14 pages, 10 figures, 4 tables, accepted for publication in A&

Low-Complexity 3D-DWT video encoder applicable to IPTV

3D-DWT encoders are good candidates for applications like professional video editing, IPTV video surveillance, live event IPTV broadcast, multispectral satellite imaging, HQ video delivery, etc., where a frame must be reconstructed as fast as possible. However, the main drawback of the algorithms that compute the 3D-DWT is the huge memory requirement in practical implementations. In this paper, and in order to considerably reduce the memory requirements of this kind of video encoders, we present a new 3D-DWT video encoder based on (a) the use of a novel frame-based 3D-DWT transform that avoids video sequence partitioning in Groups Of Pictures (GOP) and (b) a very fast run-length encoder. Furthermore, an exhaustive evaluation of the proposed encoder (3D-RLW) has been performed, analyzing the sensibility of the ¿lters employed in the 3D-DWT transform and comparing the evaluation results with other video encoders in terms of R/D, coding/decoding delay and memory consumptionThanks to Spanish Ministry of Education and Science under grants DPI2007-66796-C03-03 for funding.López ., O.; Piñol ., P.; Martinez Rach, MO.; Perez Malumbres, MJ.; Oliver Gil, JS. (2011). Low-Complexity 3D-DWT video encoder applicable to IPTV. Signal Processing: Image Communication. 26(7):358-369. https://doi.org/10.1016/j.image.2011.01.008S35836926

The effectiveness of interventions to change six health behaviours: a review of reviews

Background: Several World Health Organisation reports over recent years have highlighted the high incidence of chronic diseases such as diabetes, coronary heart disease and cancer. Contributory factors include unhealthy diets, alcohol and tobacco use and sedentary lifestyles. This paper reports the findings of a review of reviews of behavioural change interventions to reduce unhealthy behaviours or promote healthy behaviours. We included six different health-related behaviours in the review: healthy eating, physical exercise, smoking, alcohol misuse, sexual risk taking (in young people) and illicit drug use. We excluded reviews which focussed on pharmacological treatments or those which required intensive treatments (e. g. for drug or alcohol dependency). Methods: The Cochrane Library, Database of Abstracts of Reviews of Effectiveness (DARE) and several Ovid databases were searched for systematic reviews of interventions for the six behaviours (updated search 2008). Two reviewers applied the inclusion criteria, extracted data and assessed the quality of the reviews. The results were discussed in a narrative synthesis. Results: We included 103 reviews published between 1995 and 2008. The focus of interventions varied, but those targeting specific individuals were generally designed to change an existing behaviour (e. g. cigarette smoking, alcohol misuse), whilst those aimed at the general population or groups such as school children were designed to promote positive behaviours (e. g. healthy eating). Almost 50% (n = 48) of the reviews focussed on smoking (either prevention or cessation). Interventions that were most effective across a range of health behaviours included physician advice or individual counselling, and workplace- and school-based activities. Mass media campaigns and legislative interventions also showed small to moderate effects in changing health behaviours. Generally, the evidence related to short-term effects rather than sustained/longer-term impact and there was a relative lack of evidence on how best to address inequalities. Conclusions: Despite limitations of the review of reviews approach, it is encouraging that there are interventions that are effective in achieving behavioural change. Further emphasis in both primary studies and secondary analysis (e.g. systematic reviews) should be placed on assessing the differential effectiveness of interventions across different population subgroups to ensure that health inequalities are addressed.</p

Assessing hospitals' clinical risk management: Development of a monitoring instrument

<p>Abstract</p> <p>Background</p> <p>Clinical risk management (CRM) plays a crucial role in enabling hospitals to identify, contain, and manage risks related to patient safety. So far, no instruments are available to measure and monitor the level of implementation of CRM. Therefore, our objective was to develop an instrument for assessing CRM in hospitals.</p> <p>Methods</p> <p>The instrument was developed based on a literature review, which identified key elements of CRM. These elements were then discussed with a panel of patient safety experts. A theoretical model was used to describe the level to which CRM elements have been implemented within the organization. Interviews with CRM practitioners and a pilot evaluation were conducted to revise the instrument. The first nationwide application of the instrument (138 participating Swiss hospitals) was complemented by in-depth interviews with 25 CRM practitioners in selected hospitals, for validation purposes.</p> <p>Results</p> <p>The monitoring instrument consists of 28 main questions organized in three sections: 1) Implementation and organizational integration of CRM, 2) Strategic objectives and operational implementation of CRM at hospital level, and 3) Overview of CRM in different services. The instrument is available in four languages (English, German, French, and Italian). It allows hospitals to gather comprehensive and systematic data on their CRM practice and to identify areas for further improvement.</p> <p>Conclusions</p> <p>We have developed an instrument for assessing development stages of CRM in hospitals that should be feasible for a continuous monitoring of developments in this important area of patient safety.</p

Genetics of migraine in the age of genome-wide association studies

Genetic factors importantly contribute to migraine. However, unlike for rare monogenic forms of migraine, approaches to identify genes for common forms of migraine have been of limited success. Candidate gene association studies were often negative and positive results were often not replicated or replication failed. Further, the significance of positive results from linkage studies remains unclear owing to the inability to pinpoint the genes under the peaks that may be involved in migraine. Problems hampering these studies include limited sample sizes, methods of migraine ascertainment, and the heterogeneous clinical phenotype. Three genome-wide association studies are available now and have successfully identified four new genetic variants associated with migraine. One new variant (rs1835740) modulates glutamate homeostasis, thus integrates well with current concepts of neurotransmitter disturbances. This variant may be more specific for severe forms of migraine such as migraine with aura than migraine without aura. Another variant (rs11172113) implicates the lipoprotein receptor LRP1, which may interact with neuronal glutamate receptors, thus also providing a link to the glutamate pathway. In contrast, rs10166942 is in close proximity to TRPM8, which codes for a cold and pain sensor. For the first time this links a gene explicitly implicated in pain related pathways to migraine. The potential function of the fourth variant rs2651899 (PRDM16) in migraine is unclear. All these variants only confer a small to moderate change in risk for migraine, which concurs with migraine being a heterogeneous disorder. Ongoing large international collaborations will likely identify additional gene variants for migraine