Creation of orbital angular momentum states with chiral polaritonic lenses

Controlled transfer of orbital angular momentum to exciton-polariton Bose-Einstein condensate spontaneously created under incoherent, off-resonant excitation conditions is a long-standing challenge in the field of microcavity polaritonics. We demonstrate, experimentally and theoretically, a simple and efficient approach to generation of nontrivial orbital angular momentum states by using optically-induced potentials -- chiral polaritonic lenses.Comment: 5 pages, 5 figure

Microbiota-Dependent Immune Responses to Intestinal Parasites

The digestive tract plays a central role in nutrient acquisition and harbors a vast and intricate community of bacteria, fungi, viruses and parasites, collectively known as the microbiota. In recent years, there has been increasing recognition of the complex and highly contextual involvement of this microbiota in the induction and education of host innate and adaptive immune responses under homeostasis, during infection and inflammation. The gut passage and colonization by unicellular and multicellular parasite species present an immense challenge to the host immune system and to the microbial communities that provide vital support for its proper functioning. In mammals, parasitic nematodes induce distinct shifts in the intestinal microbial composition. Vice versa, the commensal microbiota has been shown to serve as a molecular adjuvant and immunomodulator during intestinal parasite infections. Moreover, similar interactions occur within insect vectors of deadly human pathogens. The gut microbiota has emerged as a crucial factor affecting vector competence in Anopheles mosquitoes, where it modulates outcomes of infections with malaria parasites. In this review, we discuss currently known involvements of the host microbiota in the instruction, support or suppression of host immune responses to gastrointestinal nematodes and protozoan parasites in mice, as well as in the malaria mosquito vector. A deeper understanding of the mechanisms underlying microbiota-dependent modulation of host and vector immunity against parasites in mammals and mosquitoes is key to a better understanding of the host-parasite relationships and the identification of more efficient approaches for intervention and treatment of parasite infections of both clinical and veterinary importance

A bacterial glycoengineered antigen for improved serodiagnosis of porcine brucellosis

Brucellosis is a highly zoonotic disease that affects animals and human beings. Brucella suis is the etiological agent of porcine brucellosis and one of the major human brucellosis pathogens. Laboratory diagnosis of porcine brucellosis mainly relies on serological tests, and it has been widely demonstrated that serological assays based on the detection of anti O-polysaccharide antibodies are the most sensitive tests. Here, we validate a recombinant glycoprotein antigen, an N-formylperosamine O-polysaccharide protein conjugate (OAg-AcrA), for diagnosis of porcine brucellosis. An indirect immunoassay based on the detection of anti-O-polysaccharide IgG antibodies was developed coupling OAg-AcrA to enzyme-linked immunosorbent assay plates (glycoiELISA). To validate the assay, 563 serum samples obtained from experimentally infected and immunized pigs, as well as animals naturally infected with B. suis biovar 1 or 2, were tested. A receiver operating characteristic (ROC) analysis was performed, and based on this analysis, the optimum cutoff value was 0.56 (relative reactivity), which resulted in a diagnostic sensitivity and specificity of 100% and 99.7%, respectively. A cutoff value of 0.78 resulted in a test sensitivity of 98.4% and a test specificity of 100%. Overall, our results demonstrate that the glyco-iELISA is highly accurate for diagnosis of porcine brucellosis, improving the diagnostic performance of current serological tests. The recombinant glycoprotein OAg-AcrA can be produced in large homogeneous batches in a standardized way, making it an ideal candidate for further validation as a universal antigen for diagnosis of "smooth" brucellosis in animals and humans.Fil: Cortina, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; ArgentinaFil: Balzano, Rodrigo E.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaFil: Rey Serantes, Diego A. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; ArgentinaFil: Caillava, Ana Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; ArgentinaFil: Elena, Sebastian. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaFil: Ferreira, A. C.. Instituto Nacional de Investigação Agrária e Veterinária; PortugalFil: Nicola, Ana M.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaFil: Ugalde, Juan Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; ArgentinaFil: Comerci, Diego José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; Argentina. Comisión Nacional de Energía Atómica; ArgentinaFil: Ciocchini, Andres Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; Argentin

A Survey of z ~ 6 Quasars in the Sloan Digital Sky Survey Deep Stripe. II. Discovery of Six Quasars at z AB>21

We present the discovery of six new quasars at z ~ 6 selected from the Sloan Digital Sky Survey (SDSS) southern survey, a deep imaging survey obtained by repeatedly scanning a stripe along the celestial equator. The six quasars are about 2 mag fainter than the luminous z ~ 6 quasars found in the SDSS main survey and 1 mag fainter than the quasars reported in Paper I. Four of them comprise a complete flux-limited sample at 21 < z_(AB) < 21.8 over an effective area of 195 deg^2. The other two quasars are fainter than z_(AB) = 22 and are not part of the complete sample. The quasar luminosity function at z ~ 6 is well described as a single power law Φ(L_(1450))α L^β_(1450) over the luminosity range –28 < M_(1450) < –25. The best-fitting slope β varies from –2.6 to –3.1, depending on the quasar samples used, with a statistical error of 0.3-0.4. About 40% of the quasars discovered in the SDSS southern survey have very narrow Lyα emission lines, which may indicate small black hole masses and high Eddington luminosity ratios, and therefore short black hole growth timescales for these faint quasars at early epochs

Evidence for electronically-driven ferroelectricity in the family of strongly correlated dimerized BEDT-TTF molecular conductors

By applying measurements of the dielectric constants and relative length changes to the dimerized molecular conductor $\kappa$-(BEDT-TTF)$_2$Hg(SCN)$_2$Cl, we provide evidence for order-disorder type electronic ferroelectricity which is driven by charge order within the (BEDT-TTF)$_2$ dimers and stabilized by a coupling to the anions. According to our density functional theory calculations, this material is characterized by a moderate strength of dimerization. This system thus bridges the gap between strongly dimerized materials, often approximated as dimer-Mott systems at 1/2 filling, and non- or weakly dimerized systems at 1/4 filling exhibiting charge order. Our results indicate that intra-dimer charge degrees of freedom are of particular importance in correlated $\kappa$-(BEDT-TTF)$_2$X salts and can create novel states, such as electronically-driven multiferroicity or charge-order-induced quasi-1D spin liquids.Comment: 6 pages, 4 figures + Supplementary Information (8 pages, 8 figures

Neural gain control measured through cortical gamma oscillations is associated with sensory sensitivity

Gamma oscillations facilitate information processing by shaping the excitatory input/output of neuronal populations. Recent studies in humans and nonhuman primates have shown that strong excitatory drive to the visual cortex leads to suppression of induced gamma oscillations, which may reflect inhibitory-based gain control of network excitation. The efficiency of the gain control measured through gamma oscillations may in turn affect sensory sensitivity in everyday life. To test this prediction, we assessed the link between self-reported sensitivity and changes in magneto-encephalographic gamma oscillations as a function of motion velocity of high-contrast visual gratings. The induced gamma oscillations increased in frequency and decreased in power with increasing stimulation intensity. As expected, weaker suppression of the gamma response correlated with sensory hypersensitivity. Robustness of this result was confirmed by its replication in the two samples: neurotypical subjects and people with autism, who had generally elevated sensory sensitivity. We conclude that intensity-related suppression of gamma response is a promising biomarker of homeostatic control of the excitation-inhibition balance in the visual cortex

A Survey of z~6 Quasars in the SDSS Deep Stripe. II. Discovery of Six Quasars at z_{AB}>21

We present the discovery of six new quasars at z~6 selected from the Sloan Digital Sky Survey (SDSS) southern survey, a deep imaging survey obtained by repeatedly scanning a stripe along the celestial equator. The six quasars are about two magnitudes fainter than the luminous z~6 quasars found in the SDSS main survey and one magnitude fainter than the quasars reported in Paper I (Jiang et al. 2008). Four of them comprise a complete flux-limited sample at 21<z_AB<21.8 over an effective area of 195 deg^2. The other two quasars are fainter than z_AB=22 and are not part of the complete sample. The quasar luminosity function at z~6 is well described as a single power law \Phi(L_{1450}) \propto L_{1450}^{\beta} over the luminosity range -28<M_{1450}<-25. The best-fitting slope \beta varies from -2.6 to -3.1, depending on the quasar samples used, with a statistical error of 0.3-0.4. About 40% of the quasars discovered in the SDSS southern survey have very narrow Lya emission lines, which may indicate small black hole masses and high Eddington luminosity ratios, and therefore short black hole growth time scales for these faint quasars at early epochs.Comment: Accepted for publication in A

Effects of the linear polarization of polariton condensates in their propagation in codirectional couplers

We report on the linear polarization of polariton condensates in a codirectional coupler that allows evanescent coupling between adjacent waveguides. During the condensate's formation, polaritons usually acquire a randomly oriented polarization, however, our results reveal a preferential orientation of the linear polarization along the waveguide propagation path. Furthermore, we observe polarization-dependent intensity oscillations in the output terminal of the coupler, and we identify the mode beating between the linear-polarized eigenmodes as the origin of these oscillations. Our findings provide an insight into the control of the polarization of polariton condensates, paving the way for the development of spin-based polaritonic architectures where condensates propagate over macroscopic distancesThis work has been partly supported by the Spanish MINECO Grant Nos. MAT2017-83722-R and PID2020-113445GB-I00. A.Y. and I.A.S. were financially supported by the Ministry of Science and Higher Education of the Russian Federation through Megagrant Number 14.Y26.31.0015 and Goszadanie No. 2019-1246. I.A.S. acknowledges also the support from theIcelandic research fund, Grant No. 163082-051. The Würzburgand Jena group acknowledges financial support within the DFGProject Nos. PE 523/18-1 and KL3124/2-1. The Würzburggroup acknowledges financial support by the German ResearchFoundation (DFG) under Germany’s Excellence Strategy−EXC2147 “ct.qmat” (Project No. 390858490) and is grateful forsupport by the state of Bavari