Étude des compétences informatiques et des attitudes du corps professoral face à l'utilisation des technologies de l'information et de la communication (TIC) à l'Institut de Technologie du Cambodge (ITC)

L'utilisation des nouvelles technologies de l'information et de la communication (NTIC) fait l'objet de discussions dans le domaine de l'éducation. La présente recherche a pour objectif principal d'identifier le profil des compétences informatiques et des attitudes du corps professoral d'une haute école de formation technologique du Cambodge au regard de l'utilisation des environnements informatiques dans sa pratique d'enseignement. Cette étude descriptive exploratoire aura comme principale retombée de contribuer au développement de l'intégration des NTIC en pédagogie universitaire au Cambodge. Nous tenterons éventuellement de mettre en lumière les besoins que cette intégration suscite. L'élaboration d'une stratégie de systématisation de l'implantation des NTIC en pédagogie universitaire pourrait être traitée dans une future étude. Le recueil de données a été réalisé à l'aide d'un questionnaire d'enquête ainsi que d'une série d'entrevues réalisées auprès du personnel enseignant de l'Institut de Technologie du Cambodge durant la session d'hiver 2001

Quantitative evaluation and reversion analysis of the attractor landscapes of an intracellular regulatory network for colorectal cancer

The molecular profiles of CMS cancer cells, statistical significance analysis of reversion targets, and synergistic effect analysis of every two nodes inhibition. (XLSX 67 kb

Characteristics of Korean Suicide: A Case-control Psychological Autopsy Study

Translated from the article published in Korean Journal of Psychology: General, Vol.31, No. 2 (2012), with permission from the Korean Psychological Association.The pattern of psychological and clinical risk factors for suicide among Korean population is an important issue. This study aimed to identify the risk factor characteristics for Korean suicides. This case-control psychological autopsy (PA) study compared 56 suicide deceased with 36 living controls matched by age and gender. Semi-structured interviews were conducted with family members, cohabitants, and the next of kin of the subjects. Data were collected on a wide range of potential risk and protective factors, including demographic, life event, clinical and psychological variables. The relative contribution of these factors to suicide was examined using a binary logistic regression model. As a result, several factors were found to significantly and independently contribute to suicide: adjustment to work and school, trusting people, problem with cohabitants, unhappiness in childhood, history of past suicide attempts, psychiatric illness, psychological stress from life events, and difficulties with life in the aspect of object and duration. Though both case group and control group have life events and difficulties such as financial problem, relationship conflicts, and so on over the ratio of 90%, the level of stress in the case groups was significantly much more severe. Besides, psychological strain was found to play an important role in suicide. Risk factors for suicide in Korea are definitely similar to those in the West, China, and Japan

No β-N-Methylamino-L-alanine (BMAA) was detected in stranded cetaceans from Galicia (North-West Spain)

The neurotoxin β-N-methylamino-L-alanine (BMAA), a non-proteinogenic amino acid produced by several species of both prokaryotic (cyanobacteria) and eukaryotic (diatoms) microorganisms, has been proposed to be associated with the development of neurodegenerative diseases. At first, BMAA appeared to be ubiquitously present worldwide in various organisms, from aquatic and terrestrial food webs. However, recent studies, using detection methods based on mass spectrometry, instead of fluorescence detection, suggest that the trophic transfer of BMAA is debatable. This study evaluated BMAA in 22 cetaceans of three different species (Phocoena phocoena, n = 8, Delphinus delphis, n = 8, and Tursiops truncatus, n = 6), found stranded in North-West Spain. BMAA analysis of the liver, kidney, or muscle tissues via sensitive liquid chromatography with tandem mass spectrometry did not reveal the presence of this compound or its isomers. The absence recorded in this study highlights the need to better understand the trophic transfer of BMAA and its anatomical distribution in marine mammals.info:eu-repo/semantics/publishedVersio

4-hydroxybenzaldehyde-chitooligomers suppresses H2O2-induced oxidative damage in microglia BV-2\ua0cells

Positive charges of chitooligomer (COS) enable COS to interact with negatively charged anionic groups on the cell surface resulting in an improvement in the biological activity of COS and its derivatives. In this study, 4-hydroxybenzaldehyde-COS (HB-COS) was synthesized and investigated for its abilities against HO-induced oxidative stress in microglia BV-2\ua0cells. Under oxidative stress, HB-COS significantly attenuated reactive oxygen species (ROS) generation and DNA oxidation, and upregulated the protein levels of antioxidative enzymes. HB-COS is therefore proposed as a potential protective agent against neuronal damage

Rat Model of Staphylococcal Enterotoxin B-Induced Rhinosinusitis

ObjectivesIt has been proposed that microbial persistence, superantigen (SA) production, and host T-cell response may be involved in the development of chronic rhinosinusitis. According to the SA hypothesis, a single intranasal application of SA such as staphylococcal enterotoxin B (SEB) may induce chronic eosinophilic rhinosinusitis. This study aimed to develop a rat model of rhinosinusitis induced by intranasally applied SEB.MethodsForty µL of SEB (100 µg/mL) or phosphate buffered saline was applied intranasally through each naris in 4 week-old Sprague-Dawley test rats (N=36) and controls (N=16), respectively. Following sacrifice at 1, 5, 14, and 28 days, the obtained nasal cavity and sinuses were prepared for histologic investigation. The histologic sections were examined in a blind manner for the ratio of the sinus spaces occupied by inflammatory cell clusters and the number of inflammatory cells in the lamina propria.ResultsInfiltration of neutrophils in the lamina propria and appearance of neutrophil clusters in the sinus spaces were observed in the SEB-applied rats. The ratio of the sinus spaces occupied by neutrophil clusters and the number of neutrophils infiltrated in the lamina propria increased significantly at day 1 as compared with the control rats.ConclusionIntranasally applied SEB induces acute neutrophilic rhinosinusitis in rats. Eosinophilic inflammation was not demonstrated. The mere presence of SA in the nose does not necessarily induce SA-induced inflammation, as suggested by the SA hypothesis