A study of A8 and A2 migrants in Nottingham

The research was commissioned by Nottingham City Council and One Nottingham in August 2008 and was conducted by a team of researchers from the Salford Housing & Urban Studies Unit at the University of Salford. The study was greatly aided by research support from Nottingham City Council Children’s Services Asylum Seeker/Refugee Support Team, as well as a number of community interviewers. The project was managed by a steering group composed of officers representing Nottingham City Council, One Nottingham, Nottingham City Homes, NHS Nottingham City, Nottinghamshire Fire & Rescue Service, Nottinghamshire Police and Basic Educational Guidance in Nottinghamshire (BEGIN). The main objective of this research was to explore the needs and experiences of A8 and A2 migrants living and working in Nottingham

Migrant workers in Rochdale and Oldham

This research focuses on the needs and experiences of Central and Eastern European migrants living and working in Rochdale and Oldham. It was commissioned by Oldham Housing Investment Partnership, Oldham Metropolitan Borough Council, Oldham Rochdale Housing Market Renewal Pathfinder and Rochdale Metropolitan Borough Council in January 2008 and was conducted by a team of researchers from the Salford Housing & Urban Studies Unit (SHUSU) at the University of Salford

Growth and kinetic Monte Carlo simulation of InAs quantum wires on vicinal substrates

AbstractSelf-assembled quantum structures have been successfully grown for some time now but control over their uniformity has proven difficult due to the stochastic nature of surface diffusion. We have investigated the effect of vicinal InP(001) substrates on the uniformity of InAs quantum wires grown on InGaAlAs lattice-matched to InP using molecular beam epitaxy. Dense quantum wires were grown on both nominally flat and vicinal substrates off-cut by 0.9° toward the [110] direction for comparison. The off-cut angle was chosen to provide terraces which match the orientation and spacing of wires grown on nominally flat substrates. A modest but statistically significant improvement in the size distribution of the wires was observed on vicinal substrates through the analysis of ultrahigh resolution scanning electron micrographs. The interface between the wires and the off-cut substrate was studied using cross-sectional high resolution scanning transmission electron microscopy. In addition, a kinetic Monte Carlo model of epitaxial growth including full strain calculations was developed to further investigate the nucleation process. Using an anisotropic bond model to account for the surface energy of different crystallographic facets, our simulations produced wires similar to those observed experimentally while demonstrating the importance of anisotropic bonding compared to anisotropic diffusion. Growth on vicinal substrates is also simulated here and indicates that off-cut substrates should indeed improve the size distribution of quantum wires under proper growth conditions

Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis

Funding The study was funded entirely by institutional funds.Peer reviewedPostprin

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

CBS domains are defined as sequence motifs that occur in several different proteins in all kingdoms of life. Although thought to be regulatory, their exact functions have been unknown. However, their importance was underlined by findings that mutations in conserved residues within them cause a variety of human hereditary diseases, including (with the gene mutated in parentheses): Wolff-Parkinson-White syndrome (γ2 subunit of AMP-activated protein kinase); retinitis pigmentosa (IMP dehydrogenase-1); congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members); and homocystinuria (cystathionine β-synthase). AMP-activated protein kinase is a sensor of cellular energy status that is activated by AMP and inhibited by ATP, but the location of the regulatory nucleotide-binding sites (which are prime targets for drugs to treat obesity and diabetes) was not characterized. We now show that tandem pairs of CBS domains from AMP-activated protein kinase, IMP dehydrogenase-2, the chloride channel CLC2, and cystathionine β-synthase bind AMP, ATP, or S-adenosyl methionine,while mutations that cause hereditary diseases impair this binding. This shows that tandem pairs of CBS domains act, in most cases, as sensors of cellular energy status and, as such, represent a newly identified class of binding domain for adenosine derivatives

The impact of conditionality on the welfare rights of EU migrants in the UK

This paper highlights and explores how conditionality operating at three levels (the EU supra-national level, the UK national level and in migrants’ mundane ‘street level’ encounters with social security administrators), come together to restrict and have a negative impact on the social rights of EU migrants living in the UK. Presenting analysis of new data generated in repeat qualitative interviews with 49 EU migrants resident in the UK, the paper makes an original contribution to understanding how the conditionality inherent in macro level EU and UK policy has seriously detrimental effects on the everyday lives of individual EU migrants

Welfare conditionality and disabled people in the UK: claimants' perspectives

In order to fully understand the impact of the extension of conditionality in the UK to include people with impairments, it is vital to give voice to those with direct experience of the welfare system. The case studies that follow are taken from interviews carried out as part of a project called Welfare Conditionality: Sanctions, Support and Behaviour Change. This is a major five-year programme of research running from 2013-2018, funded under the Economic and Social Research Council’s Centres and Large Grants Scheme (ESRC grant ES/K002163/2)

Operational deformations in long-span bridges

Journal ArticleLong-span bridges deform quasi-statically and dynamically under a range of operational conditions including wind, traffic and thermal loads, in varying patterns, at different timescales and with different amplitudes. While external loads and internal forces can only rarely be measured, there are well-developed technologies for measuring deformations and their time and space derivatives. Performance data can be checked against design limits and used for validating conceptual and numerical models which can in turn be used to estimate the external loads and internal forces. Changes in performance patterns and load–response relationships can also be used directly as a diagnostic tool, but excessive deformations themselves are also a concern in terms of serviceability. This paper describes application of a range of measurement technologies, focusing on response to extreme loads, for suspension bridges over the River Tamar (with 335 m main span) and Humber (with 1410 m man span). The effects of vehicular, thermal and wind loads on these very different structures are compared, showing that apart from rare extreme traffic and wind loads, temporal and spatial temperature variations dominate quasi-static response. Observations of deformation data and sensor performance for the two bridges are used to highlight limitations and redundancies in the instrumentation

Work, welfare and wellbeing? The impacts of welfare conditionality on people with mental health impairments in the UK

The personal, economic and social costs of mental ill-health are increasingly acknowledged by many governments and international organisations. Simultaneously, in high income nations the reach of welfare conditionality has extended to encompass many people with mental health impairments as part of on-going welfare reforms. This is particularly the case in the UK where, especially since the introduction of Employment and Support Allowance (ESA) in 2008, the rights and responsibilities of disabled people have been subject to contestation and redefinition. Following a review of the emergent international evidence on mental health and welfare conditionality, this paper explores two specific issues. First, the impacts of the application of welfare conditionality on benefit claimants with mental health impairments. Second, the effectiveness of welfare conditionality in supporting people with experience of mental ill health into paid work. In considering these questions this paper presents original analysis of data generated in qualitative longitudinal interviews with 207 UK social security benefit recipients with experience of a range of mental health issues. The evidence suggests that welfare conditionality is largely ineffective in moving people with mental health impairments into, or closer to, paid work. Indeed, in many cases it triggers negative health outcomes that make future employment less likely. It is concluded that the application of conditionality for people with mental health issues is inappropriate and should cease

Corticotropin-releasing factor receptor 1 activation during exposure to novelty stress protects against alzheimer's disease-like cognitive decline in AβPP/PS1 Mice

A lifestyle rich in physical and mental activities protects against Alzheimer's disease (AD) but the underlying mechanisms are unclear. We have proposed that this is mediated by a stress response and have shown that repeated exposure to novelty stress, which induces physical and exploratory activities, delays the progression of AD-like pathology in the TASTPM mouse model. Here, we aimed to establish the role played by corticotrophin-releasing factor receptor 1 (CRFR1), a major component of the stress axis, in TASTPM's behavioral and neuroendocrine responses to novelty and related protective effects. We show that the stress response of TASTPM mice is altered with reduced CRFR1-mediated neuroendocrine and behavioral responses to novelty and a distinct profile of behavioral responses. Repeated novelty-induced CRFR1 activation, however, mediated the improved contextual fear memory and extinction performance of TASTPM mice and increased hippocampal and fronto-cortical levels of synaptophysin, a marker of synaptic density, and fronto-cortical levels of the post-synaptic marker PSD95. The N-methyl-D-aspartate receptor (NMDAR) is the major receptor for synaptic plasticity underlying learning and memory. Although novelty-induced NMDAR activation contributed to enhancement of fear memory and synaptophysin levels, antagonism of CRFR1 and NMDAR prevented the novelty-induced increase in hippocampal synaptophysin levels but reversed the other effects of CRFR1 inactivation, i.e., the enhancement of contextual fear extinction and fronto-cortical synaptophysin and PSD95 levels. These findings suggest a novel mechanism whereby a stimulating environment can delay AD symptoms through CRFR1 activation, facilitating NMDAR-mediated synaptic plasticity and synaptogenesis in a region-dependent manner, either directly, or indirectly, by modulating PSD95. © 2013 - IOS Press and the authors. All rights reserved