Assessing the Impact of White Noise on Cognition in Individuals with and without ADHD

Although originally viewed only as a childhood disorder, Attention Deficit Hyperactivity Disorder (ADHD) is now recognized to persist into adulthood in many individuals. Adults with ADHD often demonstrate academic, cognitive, and general functioning deficits as a result of their symptoms. Theorists have suggested that features typically associated with ADHD, such as distractibility, excessive motor activity, and executive dysfunction, may stem from being under stimulated at a physiological level. This lack of arousal potentially causes individuals to seek out stimulation, making them more susceptible to background noise and other environmental stimuli. However, previous research primarily focuses on children and adolescents with ADHD, utilizes few cognitive tasks, and has demonstrated inconsistent results. This study attempted to address limitations in the current literature by examining the effects of white noise on verbal memory, working memory, and response inhibition in adults with and without ADHD. Participants were asked to complete self-report measures of ADHD symptoms and computerized cognitive tasks assessing verbal memory, working memory, and response inhibition, while wearing headphones that broadcast white noise, during half of each task, or no sound, during the other half of each task. A repeated-measures MANOVA analysis indicated that there was no main effect of noise and no significant interaction of diagnostic status and noise on scores, suggesting white noise did not facilitate selective attention. Implications and limitations are discussed

Examining Patterns of Executive Functioning Across Dimensions of Psychopathology

Executive functioning is a multifaceted collection of higher-order cognitive processes used to perform goal-oriented tasks. Although this construct is heavily researched, a major issue regarding the current literature stems from the influence of task impurity, which interferes with how executive functioning performance is interpreted. Additionally, while executive functioning has been previously explored in clinical populations, less work has evaluated this topic measuring dimensional psychopathology. The present study sought to examine the role of executive functioning, as it relates to dimensional psychopathology. Data was analyzed from a total of 731 individuals between the age of 18-59 years who took part in the Nathan Kline Institute (NKI)-Rockland project. A three-factor model of executive functioning (i.e., inhibition, shifting, and fluency) proposed by Karr et al. (2018) using scores primarily from the Delis-Kaplan Executive Function System (D-KEFS) and an original three-factor model of dimensional psychopathology (i.e., internalizing, externalizing, and thought disorder symptoms) using the Adult Self-Report (ASR) and Peter’s et al. Delusions Inventory (PDI) were constructed with confirmatory factor analyses and then compared using structural equation modeling. Results supported both three-factor models as having adequate fit for this sample and indicated that internalizing and externalizing psychopathology had positive and negative relationships with different factors of executive functioning, while thought disorders traits were not related to executive functioning. Implications for future work are discussed

Visualization and Identification of IL-7 Producing Cells in Reporter Mice

Interleukin-7 (IL-7) is required for lymphocyte development and homeostasis although the actual sites of IL-7 production have never been clearly identified. We produced a bacterial artificial chromosome (BAC) transgenic mouse expressing ECFP in the Il7 locus. The construct lacked a signal peptide and ECFP (enhanced cyan fluorescent protein ) accumulated inside IL-7-producing stromal cells in thoracic thymus, cervical thymus and bone marrow. In thymus, an extensive reticular network of IL-7-containing processes extended from cortical and medullary epithelial cells, closely contacting thymocytes. Central memory CD8 T cells, which require IL-7 and home to bone marrow, physically associated with IL-7-producing cells as we demonstrate by intravital imaging

Visualization and Identification of IL-7 Producing Cells in Reporter Mice

Interleukin-7 (IL-7) is required for lymphocyte development and homeostasis although the actual sites of IL-7 production have never been clearly identified. We produced a bacterial artificial chromosome (BAC) transgenic mouse expressing ECFP in the Il7 locus. The construct lacked a signal peptide and ECFP (enhanced cyan fluorescent protein ) accumulated inside IL-7-producing stromal cells in thoracic thymus, cervical thymus and bone marrow. In thymus, an extensive reticular network of IL-7-containing processes extended from cortical and medullary epithelial cells, closely contacting thymocytes. Central memory CD8 T cells, which require IL-7 and home to bone marrow, physically associated with IL-7-producing cells as we demonstrate by intravital imaging

Examining patterns of executive functioning across dimensions of psychopathology

BACKGROUND AND OBJECTIVES: The current study examined relationships between psychopathology and individual domains of executive functioning (EF) amongst adults. While previous studies have examined these relationships using diagnostic groups, we compared factor structures of both dimensional psychopathology and EF and used an approach to better isolate EF-specific task variance within each domain. METHODS: This study analyzed the data of 722 individuals between the ages of 18-59 years, who took part in the Nathan Kline Institute (NKI)-Rockland project. Confirmatory factor analyses were used to derive a three-factor model of EF (i.e., inhibition, shifting, and fluency) proposed by Karr et al. (2019) with scores primarily from the Delis-Kaplan Executive Function System (D-KEFS), as well as a three-factor model of psychopathology (i.e., internalizing, externalizing, and thought disorder symptoms) from the Adult Self-Report (ASR) and Peter\u27s et al. Delusions Inventory (PDI). These models were compared using structural equation modeling. RESULTS: Results demonstrated an adequate fit for both model structures and indicated that internalizing and externalizing psychopathology had positive and negative relationships with different factors of EF, while thought disorder traits were not related to EF. LIMITATIONS: This study examines pathological traits within a non-clinical sample that excluded individuals with severe mental illness. Additionally, analyses were limited by the availability of certain variables, and potential shared method variance within factors. CONCLUSIONS: Patterns of associations with EF were unique to all three aspects of dimensional psychopathology. When examined together, different dimensions of psychopathology were related to both better and worse EF performance