The Use of Physical Therapy Evaluation and Treatment to Manage a Patient following a Total Knee Arthroplasty: A Case Study

Background and Purpose: The knee is a significant structure within the musculoskeletal system, which is used for dynamic and static movement in the environment. Obesity has been found to have significant health implications within all of the body\u27s systems. The purpose of this case study is to evaluate the functional outcomes of an obese patient following a total knee arthroplasty and gain understanding of the impact that obesity has on functional improvement during postoperative physical therapy care of a total knee replacement. Case Description: The patient is a 43 year old female, who has undergone a total knee arthroplasty secondary to osteoarthritis. The patient was admitted to a transitional care unit for physical and occupational therapy evaluation and treatment. Discussion: Current research is inconclusive on the long-term recovery of obese patients who have undergone a total knee arthroplasty. Further research is needed to determine the most efficient and effective method of treatment. It is currently unclear how obesity impacts total knee arthroplasty functional recovery

Humanities World Report 2015

Reserch Trend

Humanities World Report 2015

Social Policy, Culture and Media Policy, Literature, Cultural Theor

Nationwide public perceptions regarding the acceptance of using wastewater for community health monitoring in the United States

To assess the levels of infection across communities during the coronavirus disease 2019 pandemic, researchers have measured severe acute respiratory syndrome coronavirus 2 RNA in feces dissolved in sewer water. This activity is colloquially known as sewer monitoring and is referred to as wastewater-based epidemiology in academic settings. Although global ethical principles have been described, sewer monitoring is unregulated for health privacy protection when used for public health surveillance in the United States. This study used Qualtrics XM, a national research panel provider, to recruit participants to answer an online survey. Respondents (N = 3,083) answered questions about their knowledge, perceptions of what is to be monitored, where monitoring should occur, and privacy concerns related to sewer monitoring as a public health surveillance tool. Furthermore, a privacy attitude questionnaire was used to assess the general privacy boundaries of respondents. Participants were more likely to support monitoring for diseases (92%), environmental toxins (92%), and terrorist threats (88%; e.g., anthrax). Two-third of the respondents endorsed no prohibition on location sampling scale (e.g., monitoring single residence to entire community was acceptable); the most common location category respondents wanted to prohibit sampling was at personal residences. Sewer monitoring is an emerging technology, and our study sheds light on perceptions that could benefit from educational programs in areas where public acceptance is comparatively lower. Respondents clearly communicated guard rails for sewer monitoring, and public opinion should inform future policy, application, and regulation measures

Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice

F.B. is supported by Swedish Research Council, Swedish Diabetes Foundation, Swedish Heart Lung Foundation, Swedish Foundation for Strategic Research, Knut and Alice Wallenberg foundation, Göran Gustafsson Foundation, Ingbritt and Arne Lundberg’s foundation, Swedish Heart Lung Foundation, Torsten Söderberg’s Foundation, Ragnar Söderberg’s Foundation, NovoNordisk Foundation, AFA insurances, and LUA-ALF grants from Västra Götalandsregionen and Stockholm County Council. F.B. is a recipient of ERC Consolidator Grant (European Research Council, Consolidator grant 615362—METABASE). W.M.d.V. is supported by the Finland Academy of Sciences (grants 137389, 141140 and 1272870 ), the Netherlands Organization for Scientific Research (Spinoza Award and SIAM Gravity Grant 024.002.002) and the European Research Council (ERC Advanced Grant 250172 MicrobesInside). M.N. is supported by a ZONMW-VIDI grant 2013 (016.146.327).Peer reviewedPublisher PD

Microplastics Detected in Groundwater

Low concentrations of microplastics are present in Illinois’ karst groundwater, according to a preliminary study completed in spring 2018. This is the first time that microplastics have been detected in groundwater. The study was conducted in collaboration with scientists at the Illinois State Geological Survey, Illinois State Water Survey, Loyola University Chicago, and ISTC. Full study results published in Panno, S.V., Kelly, W.R., Scott, J., Zheng, W., McNeish, R.E., Holm, N., Hoellein, T.J. and Baranski, E.L. (2019), Microplastic Contamination in Karst Groundwater Systems. Groundwater, 57: 189-196. doi:10.1111/gwat.12862.League of Women Voters of Jo Daviess County; Illinois State Geological Survey; Illinois State Water Survey; Illinois Sustainable Technology Center (Hazardous Waste Research Fund);. Illinois-Indiana Sea Grant (National Oceanic and Atmospheric Administration ; 074483-15907); National Science Foundation (CAREER 1553835).Ope

A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS.

Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA). SnoRNAs are altered in several cancers; however, their role in cell homeostasis as well as in cellular transformation remains poorly explored. Here, we show that specific subsets of snoRNAs are differentially regulated during the earliest cellular response to oncogenic RASG12V expression. We describe a novel function for one H/ACA snoRNA, SNORA24, which guides two pseudouridine modifications within the small ribosomal subunit, in RAS-induced senescence in vivo. We find that in mouse models, loss of Snora24 cooperates with RASG12V to promote the development of liver cancer that closely resembles human steatohepatitic hepatocellular carcinoma (HCC). From a clinical perspective, we further show that human HCCs with low SNORA24 expression display increased lipid content and are associated with poor patient survival. We next asked whether ribosomes lacking SNORA24-guided pseudouridine modifications on 18S rRNA have alterations in their biophysical properties. Single-molecule Fluorescence Resonance Energy Transfer (FRET) analyses revealed that these ribosomes exhibit perturbations in aminoacyl-transfer RNA (aa-tRNA) selection and altered pre-translocation ribosome complex dynamics. Furthermore, we find that HCC cells lacking SNORA24-guided pseudouridine modifications have increased translational miscoding and stop codon readthrough frequencies. These findings highlight a role for specific snoRNAs in safeguarding against oncogenic insult and demonstrate a functional link between H/ACA snoRNAs regulated by RAS and the biophysical properties of ribosomes in cancer

Microplastic Contamination in Karst Groundwater Systems

Groundwater in karst aquifers constitutes about 25% of drinking water sources globally. Karst aquifers are open systems, susceptible to contamination by surface‐borne pollutants. In this study, springs and wells from two karst aquifers in Illinois, USA, were found to contain microplastics and other anthropogenic contaminants. All microplastics were fibers, with a maximum concentration of 15.2 particles/L. The presence of microplastic was consistent with other parameters, including phosphate, chloride and triclosan, suggesting septic effluent as a source. More studies are needed on microplastic sources, abundance, and impacts on karst ecosystems

Occurrence and Fate of the Herbicide Glyphosate in Tile Drainage and Receiving Rivers in East Central Illinois

Agricultural fields in the Midwestern United States are commonly tile-drained. This drainage system is used to remove excess water from the soil profile to increase crop production and promote soil conservation. However, subsurface tile drainage can readily deliver nutrients and pesticides from agricultural fields into surrounding watersheds. Glyphosate is a widely used pesticide in Midwestern agricultural fields, especially for modified glyphosate-resistant soybean and corn cultivars. The goal of this project was to develop a reliable and accurate analytical method to monitor the occurrence of glyphosate and its metabolite, aminomethylphosphonic acid (AMPA), in tile drain water and receiving river water collected in east central Illinois agricultural lands. In this study, an isotopic dilution method was developed to analyze trace levels of glyphosate and AMPA in water using liquid chromatography-tandem mass spectrometry (LC-MS/MS), combined with pre-column derivatization and solid phase extraction for sample preparation. The method recoveries of glyphosate and AMPA during the whole monitoring period ranged from 85 to 120% and 83 to 147%, respectively. The limit of detection of the developed methods for glyphosate and AMPA was 0.10 μg/L with a relative standard deviation (RSD) of https://doi.org/10.1016/j.scitotenv.2018.09.387.Illinois Sustainable Technology Center Sponsored Research Program ; HWR17-245Ope