955 research outputs found
Modelling foraging movements of diving predators : A theoretical study exploring the effect of heterogeneous landscapes on foraging efficiency
Peer reviewedPublisher PD
Stably accessing octave-spanning microresonator frequency combs in the soliton regime
Microresonator frequency combs can be an enabling technology for optical
frequency synthesis and timekeeping in low size, weight, and power
architectures. Such systems require comb operation in low-noise, phase-coherent
states such as solitons, with broad spectral bandwidths (e.g., octave-spanning)
for self-referencing to detect the carrier-envelope offset frequency. However,
stably accessing such states is complicated by thermo-optic dispersion. For
example, in the Si3N4 platform, precisely dispersion-engineered structures can
support broadband operation, but microsecond thermal time constants have
necessitated fast pump power or frequency control to stabilize the solitons. In
contrast, here we consider how broadband soliton states can be accessed with
simple pump laser frequency tuning, at a rate much slower than the thermal
dynamics. We demonstrate octave-spanning soliton frequency combs in Si3N4
microresonators, including the generation of a multi-soliton state with a pump
power near 40 mW and a single-soliton state with a pump power near 120 mW. We
also develop a simplified two-step analysis to explain how these states are
accessed in a thermally stable way without fast control of the pump laser, and
outline the required thermal properties for such operation. Our model agrees
with experimental results as well as numerical simulations based on a
Lugiato-Lefever equation that incorporates thermo-optic dispersion. Moreover,
it also explains an experimental observation that a member of an adjacent mode
family on the red-detuned side of the pump mode can mitigate the thermal
requirements for accessing soliton states
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Sculpting ion channel functional expression with engineered ubiquitin ligases
The functional repertoire of surface ion channels is sustained by dynamic processes of trafficking, sorting, and degradation. Dysregulation of these processes underlies diverse ion channelopathies including cardiac arrhythmias and cystic fibrosis. Ubiquitination powerfully regulates multiple steps in the channel lifecycle, yet basic mechanistic understanding is confounded by promiscuity among E3 ligase/substrate interactions and ubiquitin code complexity. Here we targeted the catalytic domain of E3 ligase, CHIP, to YFP-tagged KCNQ1 ± KCNE1 subunits with a GFP-nanobody to selectively manipulate this channel complex in heterologous cells and adult rat cardiomyocytes. Engineered CHIP enhanced KCNQ1 ubiquitination, eliminated KCNQ1 surface-density, and abolished reconstituted K+ currents without affecting protein expression. A chemo-genetic variation enabling chemical control of ubiquitination revealed KCNQ1 surface-density declined with a ~ 3.5 hr t1/2 by impaired forward trafficking. The results illustrate utility of engineered E3 ligases to elucidate mechanisms underlying ubiquitin regulation of membrane proteins, and to achieve effective post-translational functional knockdown of ion channels
Sub-lethal Effects of 2,4-D Exposure on Golf Course Amphibians
Amphibians are among the most common vertebrates inhabiting golf courses. They are frequent inhabitants of golf course wetlands, where they are likely to be episodically exposed to small quantities of herbicides in proper golf course maintenance. The goal of this study was to investigate whether amphibian larvae subjected to sublethal concentrations of a common herbicide used in golf course maintenance would likely result in significant life history, locomotor, or behavioral effects (e.g., changes in growth, swimming speed, or feeding ability). For these experiments we selected as models tadpoles of the southern leopard frog (Rana sphenocephala) and the herbicide 2,4- dichlorophenoxyacetic acid (2,4-D). The study’s findings include: Some life history traits (e.g., survival to metamorphosis) may be affected by chronic exposure at high doses, but other traits (e.g., growth, timing of metamorphosis, and size at metamorphosis) are not affected. Acute exposure is unlikely to have significant impact on life history traits. Acute exposure does not alter locomotor ability. Acute exposure to 2,4-D reduces the activity of tadpoles, and it also reduces feeding activity when predators are present. We conclude that 2,4-D does not represent a particularly strong threat to amphibian larvae inhabiting golf course where the herbicide is applied responsibly
The Value of Created Dunes to address Coastal Hazards in Chesapeake Bay: Hurricane Isabel Impacts
Perhaps the most important function of a created dune, from some perspectives, is coastal protection. Since the initiation of this subtask within the overall Chesapeake Bay Dune Monitoring and Management Analysis project, Hurricane Isabel impacted the coastal plain of Virginia and significantly altered almost all Bay shorelines to one degree or another. This is particularly true of shorelines facing north, east, and south since the winds shifted as the storm passed. The original task scope has changed slightly as a result of Isabel’s passage since it was such a significant storm event and provided an opportunity to show how dunes created under different conditions responded to the storm.
Isabel impacted several of our monitoring sites, part of our ongoing dune research since 2000 (Figure 1). Three of those sites (MA3, NL42, and NL59) have “created dunes” resulting from different anthropogenic activities. The purpose of this data report is to evaluate these sites from a coastal hazard perspective and determine how they performed during Hurricane Isabel and how they have recovered
Using individual tracking data to validate the predictions of species distribution models
The authors would like to thank the College of Life Sciences of Aberdeen University and Marine Scotland Science which funded CP's PhD project. Skate tagging experiments were undertaken as part of Scottish Government project SP004. We thank Ian Burrett for help in catching the fish and the other fishermen and anglers who returned tags. We thank José Manuel Gonzalez-Irusta for extracting and making available the environmental layers used as environmental covariates in the environmental suitability modelling procedure. We also thank Jason Matthiopoulos for insightful suggestions on habitat utilization metrics as well as Stephen C.F. Palmer, and three anonymous reviewers for useful suggestions to improve the clarity and quality of the manuscript.Peer reviewedPostprintPostprintPostprintPostprintPostprin
A Kerr-microresonator optical clockwork
Kerr microresonators generate interesting and useful fundamental states of
electromagnetic radiation through nonlinear interactions of continuous-wave
(CW) laser light. Using photonic-integration techniques, functional devices
with low noise, small size, low-power consumption, scalable fabrication, and
heterogeneous combinations of photonics and electronics can be realized. Kerr
solitons, which stably circulate in a Kerr microresonator, have emerged as a
source of coherent, ultrafast pulse trains and ultra-broadband
optical-frequency combs. Using the f-2f technique, Kerr combs support
carrier-envelope-offset phase stabilization for optical synthesis and
metrology. In this paper, we introduce a Kerr-microresonator optical clockwork
based on optical-frequency division (OFD), which is a powerful technique to
transfer the fractional-frequency stability of an optical clock to a lower
frequency electronic clock signal. The clockwork presented here is based on a
silicon-nitride (SiN) microresonator that supports an optical-frequency
comb composed of soliton pulses at 1 THz repetition rate. By electro-optic
phase modulation of the entire SiN comb, we arbitrarily generate
additional CW modes between the SiN comb modes; operationally, this
reduces the pulse train repetition frequency and can be used to implement OFD
to the microwave domain. Our experiments characterize the residual frequency
noise of this Kerr-microresonator clockwork to one part in , which
opens the possibility of using Kerr combs with high performance optical clocks.
In addition, the photonic integration and 1 THz resolution of the SiN
frequency comb makes it appealing for broadband, low-resolution liquid-phase
absorption spectroscopy, which we demonstrate with near infrared measurements
of water, lipids, and organic solvents
Aeroservoelastic Testing of a Sidewall Mounted Free Flying Wind-Tunnel Model
A team comprised of the Air Force Research Laboratory (AFRL), Northrop Grumman, Lockheed Martin, and the NASA Langley Research Center conducted three j wind-tunnel tests in the Transonic Dynamics Tunnel to demonstrate active control technologies relevant to large, exible vehicles. In the rst of these three tests, a semispan, aeroelastically scaled, wind-tunnel model of a ying wing SensorCraft vehi- cle was mounted to a force balance to demonstrate gust load alleviation. In the second and third tests, the same wing was mated to a new, multi-degree-of-freedom, sidewall mount. This mount allowed the half-span model to translate vertically and pitch at the wing root, allowing better simulation of the full span vehicle's rigid-body modes. Gust Load Alleviation (GLA) and Body Freedom Flutter (BFF) suppression were successfully demonstrated. The rigid body degrees-of-freedom required that the model be own in the wind tunnel using an active control system. This risky mode of testing necessitated that a model arrestment system be integrated into the new mount. The safe and successful completion of these free-flying tests required the development and integration of custom hardware and software. This paper describes the many systems, software, and procedures that were developed as part of this effort
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