Muon-anti-neutrino <---> electron-anti-neutrino mixing: analysis of recent indications and implications for neutrino oscillation phenomenology

We reanalyze the recent data from the Liquid Scintillator Neutrino Detector (LSND) experiment, that might indicate anti-nu_muanti-nu_e mixing. This indication is not completely excluded by the negative results of established accelerator and reactor neutrino oscillation searches. We quantify the region of compatibility by means of a thorough statistical analysis of all the available data, assuming both two-flavor and three-flavor neutrino oscillations. The implications for various theoretical scenarios and for future oscillation searches are studied. The relaxation of the LSND constraints under different assumptions in the statistical analysis is also investigated.Comment: 17 pages (RevTeX) + 9 figures (Postscript) included with epsfig.st

Accelerator and Reactor Neutrino Oscillation Experiments in a Simple Three-Generation Framework

We present a new approach to the analysis of neutrino oscillation experiments, in the one mass-scale limit of the three-generation scheme. In this framework we reanalyze and recombine the most constraining accelerator and reactor data, in order to draw precise bounds in the new parameter space. We consider our graphical representations as particularly suited to show the interplay among the different oscillation channels. Within the same framework, the discovery potential of future short and long baseline experiments is also investigated, in the light of both the recent signal from the LSND experiment and the atmospheric neutrino anomaly.Comment: uuencoded compressed tar file. Figures (13) available by ftp to ftp://eku.sns.ias.edu/pub/lisi/ (192.16.204.30). Submitted to Physical Review

Reconciling solar and terrestrial neutrino oscillation evidences with minimum sacrifice

The present possible evidences in favor of neutrino masses and mixings from solar, atmospheric, and accelerator experiments cannot be all reconciled in a three-family framework, unless some data are excluded. We grade all possible three-family scenarios according to their compatibility with the available data. A recently proposed scenario appears to emerge naturally as the most likely solution to all oscillation evidences, with the only exception of the angular dependence of multi-GeV atmospheric data in the Kamiokande experiment. We describe in detail the status and the phenomenological implications of this ``minimum sacrifice'' solution.Comment: 16 pages (RevTeX) + 3 figures (postscript); requires epsfig.st

Testing violations of special and general relativity through the energy dependence of nu_mu<--->nu_tau oscillations in the Super-Kamiokande atmospheric neutrino experiment

The atmospheric neutrino data collected by the Super-Kamiokande experiment span about four decades in neutrino energy E, and are thus appropriate to probe the energy dependence of the oscillation wavelength \lambda associated to nu_munu_tau flavor transitions, when these are assumed to explain the data. Such dependence takes the form \lambda^{-1}\propto E^n in a wide class of theoretical models, including ``standard'' oscillations due to neutrino mass and mixing (n=-1), energy-independent oscillations (n=0), and violations of the equivalence principle or of Lorentz invariance (n=1). We study first how the theoretical zenith distributions of sub-GeV, multi-GeV, and upward-going muon events change for different integer values of n. Then we perform a detailed analysis of the Super-Kamiokande data by treating the energy exponent n as a free parameter, with unconstrained scale factors for both the amplitude and the phase of nu_munu_tau oscillations. We find a best-fit range n=-0.9 \pm 0.4 at 90% C.L., which confirms the standard scenario (n=-1) as the dominant oscillation mechanism, and strongly constrains possible concurrent exotic processes (n \neq -1). In particular, we work out the interesting case of leading standard oscillations plus subleading terms induced by violations of special or general relativity principles, and obtain extremely stringent upper bounds on the amplitude of such violations in the (nu_mu,nu_tau) sector.Comment: 13 pages (RevTeX) + 6 figures (PostScript, color). Requires epsfig.st

Patient and physician perspectives on biological treatment in severe asthma: a Severe Asthma Network Italy survey

: Patients with severe asthma perceive beneficial effects of biologics and good self-reported adherence to treatment, even when self-administered at home https://bit.ly/48vP70w

SANI definition of Clinical Remission in Severe Asthma: a Delphi consensus

: Severe Asthma affects about 10% of the asthmatic population, and it is characterized by a low lung function and a higher count of blood leucocytes, mainly eosinophils. To date, various definitions are used in clinical practice and in the literature to identify asthma remission: clinical remission, inflammatory remission, and complete remission. The aim of this work is to highlight a consensus for asthma remission using a Delphi method. In the context of SANI (Severe Asthma Network Italy), accounting for 57 Severe Asthma Centers and more then 2200 patients, a Board of six expert drafted a list of candidate statements in a questionnaire, which has been revised to minimize redundancies and ensure clear and consistent wording for the first round (R1) of the analysis. 32 statements have been included in the R1 questionnaire, and then submitted to a panel of 80 experts, which used a 5-points Likert scale to measure their agreement to each statement. Then, an Interim Analysis of R1 data have been performed, items were discussed and considered to produce a consistent questionnaire for the round 2 (R2) of the analysis. After this, the Board set the R2 questionnaire, which included only the important key topics. Panelists have been asked to vote the statements in the R2 questionnaire afterwards. During R2, the criteria of complete clinical remission (the absence of need for OCS, symptoms, exacerbations/attacks, and a pulmonary function stability) and those of partial clinical remission (the absence of need for OCS, and 2 out of 3 criteria: the absence of symptoms, exacerbations/attacks, and a pulmonary stability) were confirmed. This SANI Delphi Analysis defined a valuable, independent and easy to use tool to test the efficacy of different treatments in patients with severe asthma enrolled into the SANI registry

Severe asthma: One disease and multiple definitions

Introduction: There is, so far, no universal definition of severe asthma. This definition usually relies on: number of exacerbations, inhaled therapy, need for oral corticosteroids, and respiratory function. The use of such parameters varies in the different definitions used. Thus, according to the parameters chosen, each patient may result in having severe asthma or not. The aim of this study was to evaluate how the choice of a specific definition of severe asthma can change the allocation of patients. Methods: Data collected from the Severe Asthma Network Italy (SANI) registry were analyzed. All the patients included were then reclassified according to the definitions of U-BIOPRED, NICE, WHO, ATS/ERS, GINA, ENFUMOSA, and TENOR. Results: 540 patients, were extracted from the SANI database. We observed that 462 (86%) met the ATS/ERS criteria as well as the GINA criteria, 259 (48%) the U-Biopred, 222 (41%) the NICE, 125 (23%) the WHO, 313 (58%) the Enfumosa, and 251 (46%) the TENOR criteria. The mean eosinophil value were similar in the ATS/ERS, U-Biopred, and Enfumosa (528, 532 and 516 cells/mcl), higher in WHO and Tenor (567 and 570 cells/mcl) and much higher in the NICE classification (624 cells/mcl). Lung function tests resulted similarly in all groups, with WHO (67%) and ATS/ERS-GINA (73%), respectively, showing the lower and upper mean FEV1 values. Conclusions: The present observations clearly evidence the heterogeneity in the distribution of patients when different definitions of severe asthma are used. However, the recent definition of severe asthma, provided by the GINA document, is similar to that indicated in 2014 by ATS/ERS, allowing mirror reclassification of the patients examined. This lack of homogeneity could complicate the access to biological therapies. The definition provided by the GINA document, which reflects what suggested by ATS/ERS, could partially overcome the problem

Malaria and Fetal Growth Alterations in the 3(rd) Trimester of Pregnancy: A Longitudinal Ultrasound Study.

Pregnancy associated malaria is associated with decreased birth weight, but in-utero evaluation of fetal growth alterations is rarely performed. The objective of this study was to investigate malaria induced changes in fetal growth during the 3(rd) trimester using trans-abdominal ultrasound. An observational study of 876 pregnant women (398 primi- and secundigravidae and 478 multigravidae) was conducted in Tanzania. Fetal growth was monitored with ultrasound and screening for malaria was performed regularly. Birth weight and fetal weight were converted to z-scores, and fetal growth evaluated as fetal weight gain from the 26th week of pregnancy. Malaria infection only affected birth weight and fetal growth among primi- and secundigravid women. Forty-eight of the 398 primi- and secundigravid women had malaria during pregnancy causing a reduction in the newborns z-score of -0.50 (95% CI: -0.86, -0.13, P = 0.008, multiple linear regression). Fifty-eight percent (28/48) of the primi- and secundigravidae had malaria in the first half of pregnancy, but an effect on fetal growth was observed in the 3(rd) trimester with an OR of 4.89 for the fetal growth rate belonging to the lowest 25% in the population (95%CI: 2.03-11.79, P<0.001, multiple logistic regression). At an individual level, among the primi- and secundigravidae, 27% experienced alterations of fetal growth immediately after exposure but only for a short interval, 27% only late in pregnancy, 16.2% persistently from exposure until the end of pregnancy, and 29.7% had no alterations of fetal growth. The effect of malaria infections was observed during the 3(rd) trimester, despite infections occurring much earlier in pregnancy, and different mechanisms might operate leading to different patterns of growth alterations. This study highlights the need for protection against malaria throughout pregnancy and the recognition that observed changes in fetal growth might be a consequence of an infection much earlier in pregnancy.\u