Insecurity for compact surfaces of positive genus

A pair of points in a riemannian manifold $M$ is secure if the geodesics between the points can be blocked by a finite number of point obstacles; otherwise the pair of points is insecure. A manifold is secure if all pairs of points in $M$ are secure. A manifold is insecure if there exists an insecure point pair, and totally insecure if all point pairs are insecure. Compact, flat manifolds are secure. A standing conjecture says that these are the only secure, compact riemannian manifolds. We prove this for surfaces of genus greater than zero. We also prove that a closed surface of genus greater than one with any riemannian metric and a closed surface of genus one with generic metric are totally insecure.Comment: 37 pages, 11 figure

The Burkholderia cenocepacia Type VI Secretion System Effector TecA Is a Virulence Factor in Mouse Models of Lung Infection

Burkholderia cenocepacia is a member of the Burkholderia cepacia complex (Bcc), a group of bacteria with members responsible for causing lung infections in cystic fibrosis (CF) patients. The most severe outcome of Bcc infection in CF patients is cepacia syndrome, a disease characterized by necrotizing pneumonia with bacteremia and sepsis. B. cenocepacia is strongly associated with cepacia syndrome, making it one of the most virulent members of the Bcc. Mechanisms underlying the pathogenesis of B. cenocepacia in lung infections and cepacia syndrome remain to be uncovered. B. cenocepacia is primarily an intracellular pathogen and encodes the type VI secretion system (T6SS) effector TecA, which is translocated into host phagocytes. TecA is a deamidase that inactivates multiple Rho GTPases, including RhoA. Inactivation of RhoA by TecA triggers assembly of the pyrin inflammasome, leading to secretion of proinflammatory cytokines, such as interleukin-1b, from macrophages. Previous work with the B. cenocepacia clinical isolate J2315 showed that TecA increases immunopathology during acute lung infection in C57BL/6 mice and suggested that this effector acts as a virulence factor by triggering assembly of the pyrin inflammasome. Here, we extend these results using a second B. cenocepacia clinical isolate, AU1054, to demonstrate that TecA exacerbates weight loss and lethality during lung infection in C57BL/6 mice and mice engineered to have a CF genotype. Unexpectedly, pyrin was dispensable for TecA virulence activity in both mouse infection models. Our findings establish that TecA is a B. cenocepacia virulence factor that exacerbates lung inflammation, weight loss, and lethality in mouse infection models. IMPORTANCE B. cenocepacia is often considered the most virulent species in the Bcc because of its close association with cepacia syndrome in addition to its capacity to cause chronic lung infections in CF patients (1). Prior to the current study, virulence factors of B. cenocepacia important for causing lethal disease had not been identified in a CF animal model of lung infection. Results of this study describe a CF mouse model and its use in demonstrating that the T6SS effector TecA of B. cenocepacia exacerbates inflammatory cell recruitment and weight loss and is required for lethality and, thus, acts as a key virulence factor during lung infection. This model will be important in further studies to better understand TecA’s role as a virulence factor and in investigating ways to prevent or treat B. cenocepacia infections in CF patients. Additionally, TecA may be the founding member of a family of virulence factors in opportunistic pathogens

Frictional drag between quantum wells mediated by phonon exchange

We use the Kubo formalism to evaluate the contribution of acoustic phonon exchange to the frictional drag between nearby two-dimensional electron systems. In the case of free phonons, we find a divergent drag rate ($\tau_{D}^{-1}$). However, $\tau_{D}^{-1}$ becomes finite when phonon scattering from either lattice imperfections or electronic excitations is accounted for. In the case of GaAs quantum wells, we find that for a phonon mean free path $\ell_{ph}$ smaller than a critical value, imperfection scattering dominates and the drag rate varies as $ln (\ell_{ph}/d)$ over many orders of magnitude of the layer separation $d$. When $\ell_{ph}$ exceeds the critical value, the drag rate is dominated by coupling through an electron-phonon collective mode localized in the vicinity of the electron layers. We argue that the coupled electron-phonon mode may be observable for realistic parameters. Our theory is in good agreement with experimental results for the temperature, density, and $d$-dependence of the drag rate.Comment: 45 pages, LaTeX, 8 postscript file figure

Sensitivity of wide band detectors to quintessential gravitons

There are no reasons why the energy spectra of the relic gravitons, amplified by the pumping action of the background geometry, should not increase at high frequencies. A typical example of this behavior are quintessential inflationary models where the slopes of the energy spectra can be either blue or mildly violet. In comparing the predictions of scenarios leading to blue and violet graviton spectra we face the problem of correctly deriving the sensitivities of the interferometric detectors. Indeed, the expression of the signal-to-noise ratio not only depends upon the noise power spectra of the detectors but also upon the spectral form of the signal and, therefore, one can reasonably expect that models with different spectral behaviors will produce different signal-to-noise ratios. By assuming monotonic (blue) spectra of relic gravitons we will give general expressions for the signal-to-noise ratio in this class of models. As an example we studied the case of quintessential gravitons. The minimum achievable sensitivity to $h^2_{0} \Omega_{GW}$ of different pairs of detectors is computed, and compared with the theoretical expectations.Comment: 10 pages in Revtex style, 3 figure

Description of the Scenario Machine

We present here an updated description of the "Scenario Machine" code. This tool is used to carry out a population synthesis of binary stars. Previous version of the description can be found at http://xray.sai.msu.ru/~mystery//articles/review/contents.htmlComment: 32 pages, 3 figures. Corrected typo

Production and detection of relic gravitons in quintessential inflationary models

A large class of quintessential inflationary models, recently proposed by Peebles and Vilenkin, leads to post-inflationary phases whose effective equation of state is stiffer than radiation. The expected gravitational waves logarithmic energy spectra are tilted towards high frequencies and characterized by two parameters: the inflationary curvature scale at which the transition to the stiff phase occurs and the number of (non conformally coupled) scalar degrees of freedom whose decay into fermions triggers the onset of a gravitational reheating of the Universe. Depending upon the parameters of the model and upon the different inflationary dynamics (prior to the onset of the stiff evolution) the relic gravitons energy density can be much more sizeable than in standard inflationary models, for frequencies larger than 1 Hz. We estimate the required sensitivity for detection of the predicted spectral amplitude and show that the allowed region of our parameter space leads to a signal smaller (by one 1.5 orders of magnitude) than the advanced LIGO sensitivity at a frequency of 0.1 KHz. The maximal signal, in our context, is expected in the GHz region where the energy density of relic gravitons in critical units (i.e. $h_0^2 \Omega_{GW}$) is of the order of $10^{-6}$, roughly eight orders of magnitude larger than in ordinary inflationary models. Smaller detectors (not necessarily interferometers) can be relevant for detection purposes in the GHz frequency window. We suggest/speculate that future measurements through microwave cavities can offer interesting perspectives.Comment: 24 pages in Revtex style, 7 figure

A Quasi-Model-Independent Search for New Physics at Large Transverse Momentum

We apply a quasi-model-independent strategy ("Sleuth") to search for new high p_T physics in approximately 100 pb^-1 of ppbar collisions at sqrt(s) = 1.8 TeV collected by the DZero experiment during 1992-1996 at the Fermilab Tevatron. Over thirty-two e mu X, W+jets-like, Z+jets-like, and 3(lepton/photon)X exclusive final states are systematically analyzed for hints of physics beyond the standard model. Simultaneous sensitivity to a variety of models predicting new phenomena at the electroweak scale is demonstrated by testing the method on a particular signature in each set of final states. No evidence of new high p_T physics is observed in the course of this search, and we find that 89% of an ensemble of hypothetical similar experimental runs would have produced a final state with a candidate signal more interesting than the most interesting observed in these data.Comment: 28 pages, 17 figures. Submitted to Physical Review

Lymphocyte subsets and the role of Th1/Th2 balance in stressed chronic pain patients

Background: The complex regional pain syndrome (CRPS) and fibromyalgia (FM) are chronic pain syndromes occurring in highly stressed individuals. Despite the known connection between the nervous system and immune cells, information on distribution of lymphocyte subsets under stress and pain conditions is limited. Methods: We performed a comparative study in 15 patients with CRPS type I, 22 patients with FM and 37 age- and sex-matched healthy controls and investigated the influence of pain and stress on lymphocyte number, subpopulations and the Th1/Th2 cytokine ratio in T lymphocytes. Results: Lymphocyte numbers did not differ between groups. Quantitative analyses of lymphocyte subpopulations showed a significant reduction of cytotoxic CD8+ lymphocytes in both CRPS (p < 0.01) and FM (p < 0.05) patients as compared with healthy controls. Additionally, CRPS patients were characterized by a lower percentage of IL-2-producing T cell subpopulations reflecting a diminished Th1 response in contrast to no changes in the Th2 cytokine profile. Conclusions: Future studies are warranted to answer whether such immunological changes play a pathogenetic role in CRPS and FM or merely reflect the consequences of a pain-induced neurohumoral stress response, and whether they contribute to immunosuppression in stressed chronic pain patients. Copyright (c) 2008 S. Karger AG, Basel

Probing BFKL Dynamics in the Dijet Cross Section at Large Rapidity Intervals in ppbar Collisions at sqrt{s}=1800 and 630 GeV

Inclusive dijet production at large pseudorapidity intervals (delta_eta) between the two jets has been suggested as a regime for observing BFKL dynamics. We have measured the dijet cross section for large delta_eta in ppbar collisions at sqrt{s}=1800 and 630 GeV using the DO detector. The partonic cross section increases strongly with the size of delta_eta. The observed growth is even stronger than expected on the basis of BFKL resummation in the leading logarithmic approximation. The growth of the partonic cross section can be accommodated with an effective BFKL intercept of a_{BFKL}(20GeV)=1.65+/-0.07.Comment: Published in Physical Review Letter

Spin Correlation in tt-bar Production from pp-bar Collisions at sqrt(s)=1.8 TeV

The D0 collaboration has performed a study of spin correlation in tt-bar production for the process tt-bar to bb-bar W^+W^-, where the W bosons decay to e-nu or mu-nu. A sample of six events was collected during an exposure of the D0 detector to an integrated luminosity of approximately 125 pb^-1 of sqrt{s}=1.8 TeV pp-bar collisions. The standard model (SM) predicts that the short lifetime of the top quark ensures the transmission of any spin information at production to the tt-bar decay products. The degree of spin correlation is characterized by a correlation coefficient k. We find that k>-0.25 at the 68% confidence level, in agreement with the SM prediction of k=0.88.Comment: Submitted to PRL, Added references, minor changes to tex