239 research outputs found
Pair correlation analysis of Fixed Photoactivatable Analysis of Live PALM applied on the Water Channel Aquaporin -3
New vortex solution in SU(3) gauge-Higgs theory
Following a brief review of known vortex solutions in SU(N) gauge-adjoint
Higgs theories we show the existence of a new ``minimal'' vortex solution in
SU(3) gauge theory with two adjoint Higgs bosons. At a critical coupling the
vortex decouples into two abelian vortices, satisfying Bogomol'nyi type, first
order, field equations. The exact value of the vortex energy (per unit length)
is found in terms of the topological charge that equals to the N=2
supersymmetric charge, at the critical coupling. The critical coupling signals
the increase of the underlying supersymmetry.Comment: 15 page
Quantitative, Architectural Analysis of Immune Cell Subsets in Tumor-Draining Lymph Nodes from Breast Cancer Patients and Healthy Lymph Nodes
Charge conservation and time-varying speed of light
It has been recently claimed that cosmologies with time dependent speed of
light might solve some of the problems of the standard cosmological scenario,
as well as inflationary scenarios. In this letter we show that most of these
models, when analyzed in a consistent way, lead to large violations of charge
conservation. Thus, they are severly constrained by experiment, including those
where is a power of the scale factor and those whose source term is the
trace of the energy-momentum tensor. In addition, early Universe scenarios with
a sudden change of related to baryogenesis are discarded.Comment: 4 page
Multimessenger astronomy with the Einstein Telescope
Gravitational waves (GWs) are expected to play a crucial role in the
development of multimessenger astrophysics. The combination of GW observations
with other astrophysical triggers, such as from gamma-ray and X-ray satellites,
optical/radio telescopes, and neutrino detectors allows us to decipher science
that would otherwise be inaccessible. In this paper, we provide a broad review
from the multimessenger perspective of the science reach offered by the third
generation interferometric GW detectors and by the Einstein Telescope (ET) in
particular. We focus on cosmic transients, and base our estimates on the
results obtained by ET's predecessors GEO, LIGO, and Virgo.Comment: 26 pages. 3 figures. Special issue of GRG on the Einstein Telescope.
Minor corrections include
Modified granular impact force laws for the OSIRIS-REx touchdown on the surface of asteroid (101955) Bennu
The OSIRIS-REx mission collected a sample from the surface of the asteroid (101955) Bennu in October 2020. Here we study the impact of the OSIRIS-REx Touch-and-Go Sampling Acquisition Mechanism (TAGSAM) interacting with the surface of an asteroid in the framework of granular physics. Traditional approaches to estimating the penetration depth of a projectile into a granular medium include force laws and scaling relationships formulated from laboratory experiments in terrestrial-gravity conditions. However, it is unclear that these formulations extend to the OSIRIS-REx scenario of a 1300-kg spacecraft interacting with regolith in a microgravity environment. We studied the TAGSAM interaction with Bennu through numerical simulations using two collisional codes, pkdgrav and GDC-i. We validated their accuracy by reproducing the results of laboratory impact experiments in terrestrial gravity. We then performed TAGSAM penetration simulations varying the following geotechnical properties of the regolith: packing fraction (P), bulk density, inter-particle cohesion (Ïc), and angle of friction (Ï). We find that the outcome of a spacecraft-regolith impact has a non-linear dependence on packing fraction. Closely packed regolith (Pâł0.6) can effectively resist the penetration of TAGSAM if Ïâł28° and/or Ïcâł50 Pa. For loosely packed regolith (PâČ0.5), the penetration depth is governed by a drag force that scales with impact velocity to the 4/3 power, consistent with energy conservation. We discuss the importance of low-speed impact studies for predicting and interpreting spacecraft-surface interactions. We show that these low-energy events also provide a framework for interpreting the burial depths of large boulders in asteroidal regolith
A monovalent chimpanzee adenovirus Ebola vaccine boosted with MVA
BACKGROUND
The West African outbreak of Ebola virus disease that peaked in 2014 has caused more than 11,000 deaths. The development of an effective Ebola vaccine is a priority for control of a future outbreak.
METHODS
In this phase 1 study, we administered a single dose of the chimpanzee adenovirus 3 (ChAd3) vaccine encoding the surface glycoprotein of Zaire ebolavirus (ZEBOV) to 60 healthy adult volunteers in Oxford, United Kingdom. The vaccine was administered in three dose levels â 1Ă1010 viral particles, 2.5Ă1010 viral particles, and 5Ă1010 viral particles â with 20 participants in each group. We then assessed the effect of adding a booster dose of a modified vaccinia Ankara (MVA) strain, encoding the same Ebola virus glyco- protein, in 30 of the 60 participants and evaluated a reduced primeâboost interval in another 16 participants. We also compared antibody responses to inactivated whole Ebola virus virions and neutralizing antibody activity with those observed in phase 1 studies of a recombinant vesicular stomatitis virusâbased vaccine expressing a ZEBOV glycoprotein (rVSV-ZEBOV) to determine relative potency and assess durability.
RESULTS
No safety concerns were identified at any of the dose levels studied. Four weeks after immunization with the ChAd3 vaccine, ZEBOV-specific antibody responses were similar to those induced by rVSV-ZEBOV vaccination, with a geometric mean titer of 752 and 921, respectively. ZEBOV neutralization activity was also similar with the two vaccines (geo- metric mean titer, 14.9 and 22.2, respectively). Boosting with the MVA vector increased virus-specific antibodies by a factor of 12 (geometric mean titer, 9007) and increased glycoprotein-specific CD8+ T cells by a factor of 5. Significant increases in neutralizing antibodies were seen after boosting in all 30 participants (geometric mean titer, 139; P<0.001). Virus-specific antibody responses in participants primed with ChAd3 remained positive 6 months after vaccination (geometric mean titer, 758) but were significantly higher in those who had received the MVA booster (geometric mean titer, 1750; P<0.001).
CONCLUSIONS
The ChAd3 vaccine boosted with MVA elicited B-cell and T-cell immune responses to ZEBOV that were superior to those induced by the ChAd3 vaccine alone. (Funded by the Wellcome Trust and others; ClinicalTrials.gov number, NCT02240875.
Efeito do preparo do solo e resĂduo da colheita de cana-de-açĂșcar sobre a emissĂŁo de CO2
Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design
The Collaborative Cohort of Cohorts for COVID-19 Research (C4R) is a national prospective study of adults comprising 14 established US prospective cohort studies. Starting as early as 1971, investigators in the C4R cohort studies have collected data on clinical and subclinical diseases and their risk factors, including behavior, cognition, biomarkers, and social determinants of health. C4R links this pre-coronavirus disease 2019 (COVID-19) phenotyping to information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and acute and postacute COVID-related illness. C4R is largely population-based, has an age range of 18-108 years, and reflects the racial, ethnic, socioeconomic, and geographic diversity of the United States. C4R ascertains SARS-CoV-2 infection and COVID-19 illness using standardized questionnaires, ascertainment of COVID-related hospitalizations and deaths, and a SARS-CoV-2 serosurvey conducted via dried blood spots. Master protocols leverage existing robust retention rates for telephone and in-person examinations and high-quality event surveillance. Extensive prepandemic data minimize referral, survival, and recall bias. Data are harmonized with research-quality phenotyping unmatched by clinical and survey-based studies; these data will be pooled and shared widely to expedite collaboration and scientific findings. This resource will allow evaluation of risk and resilience factors for COVID-19 severity and outcomes, including postacute sequelae, and assessment of the social and behavioral impact of the pandemic on long-term health trajectories
Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium.
Development Psychopathology in context: famil
- âŠ