The Current Status of Immune Checkpoint Inhibitors in Neuro-Oncology:A Systematic Review

The introduction of immune checkpoint inhibitors (ICI), as a novel treatment modality, has transformed the field of oncology with unprecedented successes. However, the efficacy of ICI for patients with glioblastoma or brain metastases (BMs) from any tumor type is under debate. Therefore, we systematically reviewed current literature on the use of ICI in patients with glioblastoma and BMs. Prospective and retrospective studies evaluating the efficacy and survival outcomes of ICI in patients with glioblastoma or BMs, and published between 2006 and November 2019, were considered. A total of 88 studies were identified (n = 8 in glioblastoma and n = 80 in BMs). In glioblastoma, median progression-free (PFS) and overall survival (OS) of all studies were 2.1 and 7.3 months, respectively. In patients with BMs, intracranial responses have been reported in studies with melanoma and non-small-cell lung cancer (NSCLC). The median intracranial and total PFS in these studies were 2.7 and 3.0 months, respectively. The median OS in all studies for patients with brain BMs was 8.0 months. To date, ICI demonstrate limited efficacy in patients with glioblastoma or BMs. Future research should focus on increasing the local and systemic immunological responses in these patients

Predicting soil carbon loss with warming

Journal ArticleThis is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.ARISING FROM: T. W. Crowther et al. Nature 540, 104–108 (2016); doi:10.1038/nature2015

Characterising the Apertif primary beam response

Context. Phased Array Feeds (PAFs) are multi element receivers in the focal plane of a telescope that make it possible to form simultaneously multiple beams on the sky by combining the complex gains of the individual antenna elements. Recently the Westerbork Synthesis Radio Telescope (WSRT) was upgraded with PAF receivers and carried out several observing programs including two imaging surveys and a time domain survey. The Apertif imaging surveys use a configuration, where 40 partially overlapping compound beams (CBs) are simultaneously formed on the sky and arranged in an approximately rectangular shape. Aims. This manuscript aims to characterise the response of the 40 Apertif CBs to create frequency-resolved, I, XX and YY polarization empirical beam shapes. The measured CB maps can be used for image deconvolution, primary beam correction and mosaicing of Apertif imaging data. Methods. We use drift scan measurements to measure the response of each of the 40 CBs of Apertif. We derive beam maps for all individual beams in I, XX and YY polarisation in 10 or 18 frequency bins over the same bandwidth as the Apertif imaging surveys. We sample the main lobe of the beams and the side lobes up to a radius of 0.6 degrees from the beam centres. In addition, we derive beam maps for each individual WSRT dish as well. Results. We present the frequency and time dependence of the beam shapes and sizes. We compare the compound beam shapes derived with the drift scan method to beam shapes derived with an independent method using a Gaussian Process Regression comparison between the Apertif continuum images and the NRAO VLA Sky Survey (NVSS) catalogue. We find a good agreement between the beam shapes derived with the two independent methods.Comment: Accepted for publication by A&A, 14 pages, 15 figure

Characterising the Apertif primary beam response

Context. Phased array feeds (PAFs) are multi-element receivers in the focal plane of a telescope that make it possible to simultaneously form multiple beams on the sky by combining the complex gains of the individual antenna elements. Recently, the Westerbork Synthesis Radio Telescope (WSRT) was upgraded with PAF receivers to carry out several observing programs, including two imaging surveys and a time-domain survey. The Apertif imaging surveys use a configuration of 40 partially overlapping compound beams (CBs) simultaneously formed on the sky and arranged in an approximately rectangular shape. Aims. This work is aimed at characterising the response of the 40 Apertif CBs to create frequency-resolved I, XX, and YY polarization empirical beam shapes. The measured CB maps can be used for the image deconvolution, primary beam correction, and mosaicking processes of Apertif imaging data. Methods. We used drift scan measurements to measure the response of each of the 40 Apertif CBs. We derived beam maps for all individual beams in I, XX, and YY polarisation in 10 or 18 frequency bins over the same bandwidth as the Apertif imaging surveys. We sampled the main lobe of the beams and the side lobes up to a radius of 0.6 degrees from the beam centres. In addition, we derived beam maps for each individual WSRT dish. Results. We present the frequency and time dependence of the beam shapes and sizes. We compared the compound beam shapes derived with the drift scan method to beam shapes derived with an independent method using a Gaussian Process Regression comparison between the Apertif continuum images and the NRAO VLA Sky Survey (NVSS) catalogue. We find a good agreement between the beam shapes derived with the two independent methods

Continuum source catalog for the first APERTIF data release

The first data release of Apertif survey contains 3074 radio continuum images covering a thousand square degrees of the sky. The observations were performed during August 2019 to July 2020. The continuum images were produced at a central frequency 1355 MHz with the bandwidth of $\sim$150 MHz and angular resolution reaching 10". In this work we introduce and apply a new method to obtain a primary beam model using a machine learning approach, Gaussian process regression. The primary beam models obtained with this method are published along with the data products for the first Apertif data release. We apply the method to the continuum images, mosaic them and extract the source catalog. The catalog contains 249672 radio sources many of which are detected for the first time at these frequencies. We cross-match the coordinates with the NVSS, LOFAR/DR1/value-added and LOFAR/DR2 catalogs resulting in 44523, 22825 and 152824 common sources respectively. The first sample provides a unique opportunity to detect long term transient sources which have significantly changed their flux density for the last 25 years. The second and the third ones combined together provide information about spectral properties of the sources as well as the redshift estimates.Comment: 12 pages, 9 figures; accepted for publication in A&

Repeating fast radio bursts with WSRT/Apertif

Context. Repeating fast radio bursts (FRBs) present excellent opportunities to identify FRB progenitors and host environments as well as to decipher the underlying emission mechanism. Detailed studies of repeating FRBs might also hold clues as to the origin of FRBs as a population. Aims. We aim to detect bursts from the first two repeating FRBs, FRB 121102 (R1) and FRB 180814.J0422+73 (R2), and to characterise their repeat statistics. We also want to significantly improve the sky localisation of R2 and identify its host galaxy. Methods. We used the Westerbork Synthesis Radio Telescope to conduct extensive follow-up of these two repeating FRBs. The new phased-array feed system, Apertif, allows one to cover the entire sky position uncertainty of R2 with fine spatial resolution in a single pointing. The data were searched for bursts around the known dispersion measures of the two sources. We characterise the energy distribution and the clustering of detected R1 bursts. Results. We detected 30 bursts from R1. The non-Poissonian nature is clearly evident from the burst arrival times, which is consistent with earlier claims. Our measurements indicate a dispersion measure (DM) of 563.5(2) pc cm(-3), suggesting a significant increase in DM over the past few years. Assuming a constant position angle across the burst, we place an upper limit of 8% on the linear polarisation fraction for the brightest burst in our sample. We did not detect any bursts from R2. Conclusions. A single power-law might not fit the R1 burst energy distribution across the full energy range or widely separated detections. Our observations provide improved constraints on the clustering of R1 bursts. Our stringent upper limits on the linear polarisation fraction imply a significant depolarisation, either intrinsic to the emission mechanism or caused by the intervening medium at 1400 MHz, which is not observed at higher frequencies. The non-detection of any bursts from R2, despite nearly 300 h of observations, implies either a highly clustered nature of the bursts, a steep spectral index, or a combination of the two assuming that the source is still active. Another possibility is that R2 has turned off completely, either permanently or for an extended period of time

First release of Apertif imaging survey data

Context. Apertif is a phased-array feed system for the Westerbork Synthesis Radio Telescope, providing forty instantaneous beams over 300 MHz of bandwidth. A dedicated survey program utilizing this upgrade started on 1 July 2019, with the last observations taken on 28 February 2022. The imaging survey component provides radio continuum, polarization, and spectral line data. Aims. Public release of data is critical for maximizing the legacy of a survey. Toward that end, we describe the release of data products from the first year of survey operations, through 30 June 2020. In particular, we focus on defining quality control metrics for the processed data products. Methods. The Apertif imaging pipeline, Apercal, automatically produces non-primary beam corrected continuum images, polarization images and cubes, and uncleaned spectral line and dirty beam cubes for each beam of an Apertif imaging observation. For this release, processed data products are considered on a beam-by-beam basis within an observation. We validate the continuum images by using metrics that identify deviations from Gaussian noise in the residual images. If the continuum image passes validation, we release all processed data products for a given beam. We apply further validation to the polarization and line data products and provide flags indicating the quality of those data products. Results. We release all raw observational data from the first year of survey observations, for a total of 221 observations of 160 independent target fields, covering approximately one thousand square degrees of sky. Images and cubes are released on a per beam basis, and 3374 beams (of 7640 considered) are released. The median noise in the continuum images is 41.4 uJy beam(-1), with a slightly lower median noise of 36.9 uJy beam(-1) in the Stokes V polarization image. The median angular resolution is 11.6 \u27\u27/sin delta. The median noise for all line cubes, with a spectral resolution of 36.6 kHz, is 1.6 mJy beam(-1), corresponding to a 3-sigma H i column density sensitivity of 1.8 x 10(20) atoms cm(-2) over 20 km s(-1) (for a median angular resolution of 24 \u27\u27 x 15 \u27\u27). Line cubes at lower frequency have slightly higher noise values, consistent with the global RFI environment and overall Apertif system performance. We also provide primary beam images for each individual Apertif compound beam. The data are made accessible using a Virtual Observatory interface and can be queried using a variety of standard tools

Fire emissions from C-3 and C-4 vegetation and their influence on interannual variability of atmospheric CO2 and delta (CO2) - C- 13

Measurements of atmospheric trace gases provide evidence that fire emissions increased during the 1997/1998 El Niño event and these emissions contributed substantially to global C