2,229 research outputs found
IFEMS, an Interactive Finite Element Modeling System Using a CAD/CAM System
A method of coupling a CAD/CAM system with a general purpose finite element mesh generator is described. The three computer programs which make up the interactive finite element graphics system are discussed
OCT for glaucoma diagnosis, screening and detection of glaucoma progression.
Optical coherence tomography (OCT) is a commonly used imaging modality in the evaluation of glaucomatous damage. The commercially available spectral domain (SD)-OCT offers benefits in glaucoma assessment over the earlier generation of time domain-OCT due to increased axial resolution, faster scanning speeds and has been reported to have improved reproducibility but similar diagnostic accuracy. The capabilities of SD-OCT are rapidly advancing with 3D imaging, reproducible registration, and advanced segmentation algorithms of macular and optic nerve head regions. A review of the evidence to date suggests that retinal nerve fibre layer remains the dominant parameter for glaucoma diagnosis and detection of progression while initial studies of macular and optic nerve head parameters have shown promising results. SD-OCT still currently lacks the diagnostic performance for glaucoma screening
PUBLIC UTILITIES - RATES - CONSTITUTIONALITY OF STATUTES PROHIBITING MINIMUM OR SERVICE CHARGES
An Oklahoma statute required that the consumer should be charged only for the gas he used as registered on a meter. The inhabitants of a certain town supplied with gas by petitioner were predominantly small consumers so that on a straight-line meter rate they did not pay for the cost of service. An increase in the rate would not solve the difficulty. The company petitioned the commission for authority to impose either a service charge or a minimum charge. The commission denied the petition. Held, that as applied to this particular case, the statute was unconstitutional and the petition should have been granted. Avant Gas Service Co. v. Corporation Commission, (Okla. 1939) 89 P. (2d) 291
Proteostatic regulation in neuronal compartments
Neurons continuously adapt to external cues and challenges, including stimulation, plasticity-inducing signals and aging. These adaptations are critical for neuronal physiology and extended survival. Proteostasis is the process by which cells adjust their protein content to achieve the specific protein repertoire necessary for cellular function. Due to their complex morphology and polarized nature, neurons possess unique proteostatic requirements. Proteostatic control in axons and dendrites must be implemented through regulation of protein synthesis and degradation in a decentralized fashion, but at the same time, it requires integration, at least in part, in the soma. Here, we discuss current understanding of neuronal proteostasis, as well as open questions and future directions requiring further exploration
Super-resolution imaging and estimation of protein copy numbers at single synapses with DNA-PAINT
In the brain, the strength of each individual synapse is defined by the complement of proteins present or the "local proteome." Activity-dependent changes in synaptic strength are the result of changes in this local proteome and posttranslational protein modifications. Although most synaptic proteins have been identified, we still know little about protein copy numbers in individual synapses and variations between synapses. We use DNA-point accumulation for imaging in nanoscale topography as a single-molecule super-resolution imaging technique to visualize and quantify protein copy numbers in single synapses. The imaging technique provides near-molecular spatial resolution, is unaffected by photobleaching, enables imaging of large field of views, and provides quantitative molecular information. We demonstrate these benefits by accessing copy numbers of surface AMPA-type receptors at single synapses of rat hippocampal neurons along dendritic segments
Speed-based Filtration and DBSCAN of Event-based Camera Data with Neuromorphic Computing
Spiking neural networks are powerful computational elements that pair well
with event-based cameras (EBCs). In this work, we present two spiking neural
network architectures that process events from EBCs: one that isolates and
filters out events based on their speeds, and another that clusters events
based on the DBSCAN algorithm.Comment: 8 pages, 5 figures, Submitted to Neuro Inspired Computational
Elements Conference 202
Functional Specification of the RAVENS Neuroprocessor
RAVENS is a neuroprocessor that has been developed by the TENNLab research
group at the University of Tennessee. Its main focus has been as a vehicle for
chip design with memristive elements; however it has also been the vehicle for
all-digital CMOS development, plus it has implementations on FPGA's,
microcontrollers and software simulation. The software simulation is supported
by the TENNLab neuromorphic software framework so that researchers may develop
RAVENS solutions for a variety of neuromorphic computing applications. This
document provides a functional specification of RAVENS that should apply to all
implementations of the RAVENS neuroprocessor.Comment: 17 pages, 11 figure
Febrile Convulsions as a Problem in Waiting Times
A simple hypothesis on the occurrence of febrile convulsions is posed. This is (1) that certain children are genetically predisposed, and (2) that for such children, the probability of the first attack occurring in year 1, 2, etc., is essentially constant up to the end of the period during which the attacks can take place. These assumptions lead to a probability model which agrees well with data on age at first attack in the Town of Tecumseh, Mich. It appears that susceptibility does not gradually diminish, but rather disappears abruptly. The calculation yields an estimate of the proportion of children, among those susceptible, who will have at least one attack before they exceed the age of suceptibility. Penetrance of the condition, measured in this way, is nearly complete: 93.8% will have manifested the condition by age 7. The population frequency of the susceptible type of child is found to be 3.90%. If one assumes the simple dominant mode of inheritance of Frantzen et al. to be correct, this estimate of population frequency leads to an estimate of the gene frequency. This is approximately p = 0.02. The homozygote would therefore have a frequency of 4 per 10,000. Some speculations on verifying this theory of inheritance by identifying the homozygote are given. RÉSUMÉ On Émet une hypothÈse simple sur la survenue des convulsions fÉbriles, À savoir (1) que certains enfants sont gÉnÉtiquement prÉdisposÉs et (2) que pour ces enfants la probabilitÉ d'apparition de la premiÈre crise dans la premiÈre, la seconde annÉe, etc. est essentiellement constante jusqu'À la fin de la pÉriode pendant laquelle les crises peuvent survenir. De telles suppositions conduisent ÀÉtablir un modÈle de probabilite qui concorde bien avec les donnÉes sur l'Âge de la premiÈre crise, dans la ville de Techumseh, dans le Michigan. Il en ressort que cette prÉdisposition ne diminue pas progressivement, mais au contraire, disparaÎt brusquement. Les calculs permettent d'estimer la proportion d'enfants prÉdisposÉs qui auront au moins une crise, avant d'avoir dÉpassÉ l'Âge limite de la prÉdisposition. La pÉnÉtrance de cette condition, ainsi ÉvaluÉe, est presque complÈte: 93.8% des enfants auront manifestÉ cette condition À l'Âge de 7 ans. La frÉquence des enfants prÉdisposÉs dans la population est de 3.90%. Si l'on considÈre que le mode d'hÉrÉditÉ dominante simple de Frantzen est valable, cette estimation de la frÉquence dans la population conduit À une Évaluation de la frÉquence du gÈne. Celle-ci est approximativement de p = 0.02; l'homozygote aurait done une frÉquence de 4/10.000. Les possibilitÉs de vÉrifier cette thÉorie des modalitÉs hÉrÉditaires par l'identification de l'homozygote sont discutÉes.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65705/1/j.1528-1157.1972.tb05265.x.pd
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