Detecting the human fingerprint in the summer 2022 western-central European soil drought

In the 2022 summer, western-central Europe and several other regions in the northern extratropics experienced substantial soil moisture deficits in the wake of precipitation shortages and elevated temperatures. Much of Europe has not witnessed a more severe soil drought since at least the mid-20th century, raising the question whether this is a manifestation of our warming climate. Here, we employ a well-established statistical approach to attribute the low 2022 summer soil moisture to human-induced climate change using observation-driven soil moisture estimates and climate models. We find that in western-central Europe, a June-August root zone soil moisture drought such as in 2022 is expected to occur once in 20 years in the present climate but would have occurred only about once per century during preindustrial times. The entire northern extratropics show an even stronger global warming imprint with a 20-fold soil drought probability increase or higher, but we note that the underlying uncertainty is large. Reasons are manifold but include the lack of direct soil moisture observations at the required spatiotemporal scales, the limitations of remotely sensed estimates, and the resulting need to simulate soil moisture with land surface models driven by meteorological data. Nevertheless, observation-based products indicate long-term declining summer soil moisture for both regions, and this tendency is likely fueled by regional warming, while no clear trends emerge for precipitation. Finally, our climate model analysis suggests that under 2C global warming, 2022-like soil drought conditions would become twice as likely for western-central Europe compared to today and would take place nearly every year across the northern extratropics.</p

Detection and replication of QTL underlying resistance to gastrointestinal nematodes in adult sheep using the ovine 50K SNP array

16 p.Persistence of gastrointestinal nematode (GIN) infection and the related control methods have major impacts on the sheep industry worldwide. Based on the information generated with the Illumina OvineSNP50 BeadChip (50 K chip), this study aims at confirming quantitative trait loci (QTL) that were previously identified by microsatellite ‑ based genome scans and identifying new QTL and allelic variants that are associated with indicator traits of parasite resistance in adult sheep. We used a commercial half ‑ sib population of 518 Spanish Churra ewes with available data for fecal egg counts (FEC) and serum levels of immunoglobulin A (IgA) to perform different genome scan QTL mapping analyses based on classical linkage analysis (LA), a combined linkage disequilibrium and linkage analysis (LDLA) and a genome ‑ wide association study (GWAS)This work was supported by a competitive grant from the Castilla and León regional government (Junta de Castilla y León) (Ref. LE245A12-2) and the AGL2012-34437 project funded by the Spanish Ministry of Economy and Competitiveness (MINECO). M Atlija is a grateful grantee of a Marie Curie fellowship funded by the EC-funded Initial Training Network (ITN) NematodeSystemHealth (FP7-PEOPLE-2010-ITN Ref. 264639). B Gutiérrez-Gil is funded through the Spanish “Ramón y Cajal” Programme (RYC-2012-10230) from the MINECO.S

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Research and Design of a Routing Protocol in Large-Scale Wireless Sensor Networks

无线传感器网络，作为全球未来十大技术之一，集成了传感器技术、嵌入式计算技术、分布式信息处理和自组织网技术，可实时感知、采集、处理、传输网络分布区域内的各种信息数据，在军事国防、生物医疗、环境监测、抢险救灾、防恐反恐、危险区域远程控制等领域具有十分广阔的应用前景。 本文研究分析了无线传感器网络的已有路由协议，并针对大规模的无线传感器网络设计了一种树状路由协议，它根据节点地址信息来形成路由，从而简化了复杂繁冗的路由表查找和维护，节省了不必要的开销，提高了路由效率，实现了快速有效的数据传输。 为支持此路由协议本文提出了一种自适应动态地址分配算——ADAR（AdaptiveDynamicAddre...As one of the ten high technologies in the future, wireless sensor network, which is the integration of micro-sensors, embedded computing, modern network and Ad Hoc technologies, can apperceive, collect, process and transmit various information data within the region. It can be used in military defense, biomedical, environmental monitoring, disaster relief, counter-terrorism, remote control of haz...学位：工学硕士院系专业：信息科学与技术学院通信工程系_通信与信息系统学号：2332007115216