EXTENDING THE INDUCTION PERIOD OF CRYSTALLIZATION FOULING THROUGH SURFACE COATING

To minimize the negative effects of scale formation in heat exchangers, new anti-fouling strategies are focusing on the modification of heat transfer surfaces. These modifications should lead to tailored made surfaces for different technical applications. Aim of this surface modification is the extension of the induction period to minimize the negative effects of fouling and maximize the endurance of the heat exchanger. To achieve such, different surface coatings on stainless steel were investigated in respect of fouling tendency. The effect of flow velocity respectively Reynolds number on the induction time of CaSO4 crystallization fouling were tested in different test units. Diamond like carbon coatings are extending the induction time in every measured flow velocity. At higher Reynolds numbers, the effect of different surface crystallization due to energetic modification is reduced because of the dominating effect of the low adhesive surface. Thus the induction time can be extended by the factor of 2 for low fluid velocities (DLC or SICON®) and more than 20 for higher Reynolds numbers (DLC and SICON®). The combination of limited nucleation spots due to electro-chemical treatment of the substrate before coating can be a tailored made surface with maximum induction time for crystallization fouling

Simple heuristics for the assembly line worker assignment and balancing problem

We propose simple heuristics for the assembly line worker assignment and balancing problem. This problem typically occurs in assembly lines in sheltered work centers for the disabled. Different from the classical simple assembly line balancing problem, the task execution times vary according to the assigned worker. We develop a constructive heuristic framework based on task and worker priority rules defining the order in which the tasks and workers should be assigned to the workstations. We present a number of such rules and compare their performance across three possible uses: as a stand-alone method, as an initial solution generator for meta-heuristics, and as a decoder for a hybrid genetic algorithm. Our results show that the heuristics are fast, they obtain good results as a stand-alone method and are efficient when used as a initial solution generator or as a solution decoder within more elaborate approaches.Comment: 18 pages, 1 figur

Measuring the Solar Radius from Space during the 2003 and 2006 Mercury Transits

The Michelson Doppler Imager (MDI) aboard the Solar and Heliospheric Observatory observed the transits of Mercury on 2003 May 7 and 2006 November 8. Contact times between Mercury and the solar limb have been used since the 17th century to derive the Sun's size but this is the first time that high-quality imagery from space, above the Earth's atmosphere, has been available. Unlike other measurements this technique is largely independent of optical distortion. The true solar radius is still a matter of debate in the literature as measured differences of several tenths of an arcsecond (i.e., about 500 km) are apparent. This is due mainly to systematic errors from different instruments and observers since the claimed uncertainties for a single instrument are typically an order of magnitude smaller. From the MDI transit data we find the solar radius to be 960".12 +/- 0".09 (696,342 +/- 65 km). This value is consistent between the transits and consistent between different MDI focus settings after accounting for systematic effects.Comment: Accepted for publication in The Astrophysical Journal (2012 March 5

Generation and characterization of a mitotane-resistant adrenocortical cell line

Mitotane is the only drug approved for the therapy of adrenocortical carcinoma (ACC). Its clinical use is limited by the occurrence of relapse during therapy. To investigate the underlying mechanisms in vitro, we here generated mitotane-resistant cell lines. After long-term pulsed treatment of HAC-15 human adrenocortical carcinoma cells with 70 µM mitotane, we isolated monoclonal cell populations of treated cells and controls and assessed their respective mitotane sensitivities by MTT assay. We performed exome sequencing and electron microscopy, conducted gene expression microarray analysis and determined intracellular lipid concentrations in the presence and absence of mitotane. Clonal cell lines established after pulsed treatment were resistant to mitotane (IC50 of 102.2 ± 7.3 µM (n = 12) vs 39.4 ± 6.2 µM (n = 6) in controls (biological replicates, mean ± s.d., P = 0.0001)). Unlike nonresistant clones, resistant clones maintained normal mitochondrial and nucleolar morphology during mitotane treatment. Resistant clones largely shared structural and single nucleotide variants, suggesting a common cell of origin. Resistance depended, in part, on extracellular lipoproteins and was associated with alterations in intracellular lipid homeostasis, including levels of free cholesterol, as well as decreased steroid production. By gene expression analysis, resistant cells showed profound alterations in pathways including steroid metabolism and transport, apoptosis, cell growth and Wnt signaling. These studies establish an in vitro model of mitotane resistance in ACC and point to underlying molecular mechanisms. They may enable future studies to overcome resistance in vitro and improve ACC treatment in vivo

Transient magnetoconductivity of photoexcited electrons

Transient magnetotransport of two-dimensional electrons with partially-inverted distribution excited by an ultrashort optical pulse is studied theoretically. The time-dependent photoconductivity is calculated for GaAs-based quantum wells by taking into account the relaxation of electron distribution caused by non-elastic electron-phonon interaction and the retardation of the response due to momentum relaxation and due to a finite capacitance of the sample. We predict large-amplitude transient oscillations of the current density and Hall field (Hall oscillations) with frequencies corresponding to magnetoplasmon range, which are initiated by the instability owing to the absolute negative conductivity effect.Comment: 21 pages, 6 fig

Hanle effect in the CN violet system with LTE modeling

Weak entangled magnetic fields with mixed polarity occupy the main part of the quiet Sun. The Zeeman effect diagnostics fails to measure such fields because of cancellation in circular polarization. However, the Hanle effect diagnostics, accessible through the second solar spectrum, provides us with a very sensitive tool for studying the distribution of weak magnetic fields on the Sun. Molecular lines are very strong and even dominate in some regions of the second solar spectrum. The CN $B {}^{2} \Sigma - X {}^{2} \Sigma$ system is one of the richest and most promising systems for molecular diagnostics and well suited for the application of the differential Hanle effect method. The aim is to interpret observations of the CN $B {}^{2} \Sigma - X {}^{2} \Sigma$ system using the Hanle effect and to obtain an estimation of the magnetic field strength. We assume that the CN molecular layer is situated above the region where the continuum radiation is formed and employ the single-scattering approximation. Together with the Hanle effect theory this provides us with a model that can diagnose turbulent magnetic fields. We have succeeded in fitting modeled CN lines in several regions of the second solar spectrum to observations and obtained a magnetic field strength in the range from 10--30 G in the upper solar photosphere depending on the considered lines.Comment: Accepted for publication in Astronomy and Astrophysic

Educating planners in Europe: A review of 21st century study programmes

A  Education for urban, regional and spatial planning has become a regular subject throughout most European nations; this can be attributed in part to European policies promoting planning and spatially balanced development, but also to the recognition that planning can support sustainability. Nevertheless, there is lingering and justifiable concern about the status, profile and recognition of planning as a profession in its own right with the result that planning and planning education remain contested territories in academia. Conceptions of planning differ between countries and over time. The array of different planning cultures and associated educational models and pedagogies that traditionally have coexisted in Europe mean that education for planning can be either very visible or leading a shadow existence being embedded in programmes of other disciplines. While planning education provision customarily has been shaped by changes in planning practice paradigms and the profession, in 21st century Europe the provision is also influenced by European integration policies, the Bologna process and powerful transformations affecting the higher education sector writ large. This review seeks to advance our understanding of the complex dynamics at work, which to date have been only partially explored in the literature, by taking stock of the current state-of-play of planning education provision in Europe. Aside from examining the factors influencing planning education in Europe, an inventory of planning education programmes available throughout the member states of the Council of Europe was developed to quantify the provision as a critical first step. Figures indicate a substantial increase in the number of programmes when compared to limited historical data. Data also suggest an underdeveloped provision for education in planning in about ten per cent of European countries. Country case studies with historically differing planning cultures and education provision, i.e., Spain, Portugal, Finland, Poland, Slovakia, the United Kingdom and Switzerland are used to compare and explore trends and developments (e.g., in respect to programme structure, curriculum content and focus, professional conceptions, specialisms) in detail. Findings demonstrate, both, an enduring power of national preferences and traditions but also some emerging commonalities. Overall a picture of increasing pluralism and diversity of education models transpires in the aftermath of Bologna which may contravene efforts to establish cross-national professional recognition and standards. Education for planning seems to embrace trends to provide increasingly international learning experiences and degrees while the provision of flexible recognised (online) degree programmes remains sparse. Recommendations for future actions and strategies to further develop and strengthen the field which is at present complex and little coordinated conclude the contribution