Deciduous enamel 3D microwear texture analysis as an indicator of childhood diet in medieval Canterbury, England

This study conducted the first three dimensional microwear texture analysis of human deciduous teeth to reconstruct the physical properties of medieval childhood diet (age 1-8yrs) at St Gregory's Priory and Cemetery (11th to 16th century AD) in Canterbury, England. Occlusal texture complexity surfaces of maxillary molars from juvenile skeletons (n=44) were examined to assess dietary hardness. Anisotropy values were calculated to reconstruct dietary toughness, as well as jaw movements during chewing. Evidence of weaning was sought, and variation in the physical properties of food was assessed against age and socio-economic status. Results indicate that weaning had already commenced in the youngest children. Diet became tougher from four years of age, and harder from age six. Variation in microwear texture surfaces was related to historical textual evidence that refers to lifestyle developments for these age groups. Diet did not vary with socio-economic status, which differs to previously reported patterns for adults. We conclude, microwear texture analyses can provide a non-destructive tool for revealing subtle aspects of childhood diet in the past

Experimental approaches to referential domains and the on-line processing of referring expressions in unscripted conversation

Peer reviewedPublisher PD

Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response

Certain bacterial pathogens are able to evade the host immune system and persist within the human host. The consequences of persistent bacterial infections potentially include increased morbidity and mortality from the infection itself as well as an increased risk of dissemination of disease. Eradication of persistent infections is difficult, often requiring prolonged or repeated courses of antibiotics. During persistent infections, a population or subpopulation of bacteria exists that is refractory to traditional antibiotics, possibly in a non-replicating or metabolically altered state. This review highlights the clinical significance of persistent infections and discusses different in vitro models used to investigate the altered physiology of bacteria during persistent infections. We specifically focus on recent work establishing increased protection against oxidative stress as a key element of the altered physiologic state across different in vitro models and pathogens

Hα\alpha Emission From Active Equal-mass, Wide M Dwarf Binaries

We identify a sample of near-equal mass wide binary M dwarf systems from the SLoWPoKES catalog of common proper-motion binaries and obtain follow-up observations of their chromospheric activity as measured by the H$\alpha$ emission line. We present optical spectra for both components of 48 candidate M dwarf binaries, confirming their mid-M spectral types. Of those 48 coeval pairs, we find eight with H$\alpha$ emission from both components, three with weak emission in one component and no emission in the other, and 37 with two inactive components. We find that of the eleven pairs with at least one active component, only three follow the net trend of decreasing activity strength $L_{\rm H\alpha}/L_{\rm bol}$ with later spectral type. The difference in quiescent activity strength between the A and B components is larger than what would be expected based on the small differences in color (mass). For five binaries with two active components, we present 47 hours of time-resolved spectroscopy, observed on the ARC 3.5-m over twelve different nights. For four of the five pairs, the slightly redder (B) component exhibits a higher level of H$\alpha$ emission during the majority of the observations and the redder objects are the only components to flare. The full range of H$\alpha$ emission observed on these variable mid-M dwarfs is comparable to the scatter in H$\alpha$ emission found in single-epoch surveys of mid-M dwarfs, indicating that variability could be a major factor in the spread of observed activity strengths. We also find that variability is independent of both activity strength and spectral type.Comment: 10 pages, 6 figures, accepted for publication in PAS

K2 Ultracool Dwarfs Survey II: The White Light Flare Rate of Young Brown Dwarfs

We use Kepler K2 Campaign 4 short-cadence (one-minute) photometry to measure white light flares in the young, moving group brown dwarfs 2MASS J03350208+2342356 (2M0335+23) and 2MASS J03552337+1133437 (2M0355+11), and report on long-cadence (thirty-minute) photometry of a superflare in the Pleiades M8 brown dwarf CFHT-PL-17. The rotation period (5.24 hr) and projected rotational velocity ($45$ km s$^{-1}$) confirm 2M0335+23 is inflated ($R \ge 0.20 R_\odot$) as predicted for a $0.06M_\odot$, 26-Myr old brown dwarf $\beta$Pic moving group member. We detect 22 white light flares on 2M0335+23. The flare frequency distribution follows a power-law distribution with slope $-\alpha = -1.8 \pm 0.2$ over the range $10^{31}$ to $10^{33}$ erg. This slope is similar to that observed in the Sun and warmer flare stars, and is consistent with lower energy flares in previous work on M6-M8 very-low-mass stars; taken the two datasets together, the flare frequency distribution for ultracool dwarfs is a power law over 4.3 orders of magnitude. The superflare ($2.6\times10^{34}$ erg) on CFHT-PL-17 shows higher energy flares are possible. We detect no flares down to a limit of $2 \times 10^{30}$ erg in the nearby L$5\gamma$ AB Dor Moving Group brown dwarf 2M0355+11, consistent with the view that fast magnetic reconnection is suppressed in cool atmospheres. We discuss two multi-peaked flares observed in 2M0335+23, and argue that these complex flares can be understood as sympathetic flares, in which a fast-mode MHD waves similar to EUV waves in the Sun trigger magnetic reconnection in different active regions.Comment: Accepted version, The Astrophysical Journa

Flares in Open Clusters with K2. I. M45 (Pleiades), M44 (Praesepe) and M67

The presence and strength of a stellar magnetic field and activity is rooted in a star's fundamental parameters such as mass and age. Can flares serve as an accurate stellar "clock"? To explore if we can quantify an activity-age relation in the form of a flaring-age relation, we measured trends in the flaring rates and energies for stars with different masses and ages. We investigated the time-domain photometry provided by Kepler's follow-up mission K2 and searched for flares in three solar metallicity open clusters with well-known ages, M45 (0.125 Gyr), M44 (0.63 Gyr), and M67 (4.3 Gyr). We updated and employed the automated flare finding and analysis pipeline Appaloosa, originally designed for Kepler. We introduced a synthetic flare injection and recovery subroutine to ascribe detection and energy recovery rates for flares in a broad energy range for each light curve. We collected a sample of 1 761 stars, mostly late-K to mid-M dwarfs and found 751 flare candidates with energies ranging from $4\cdot10^{32}$ erg to $6\cdot10^{34}$ erg, of which 596 belong to M45, 155 to M44, and none to M67. We find that flaring activity depends both on $T_\mathrm{eff}$, and age. But all flare frequency distributions have similar slopes with $\alpha \approx2.0-2.4$, supporting a universal flare generation process. We discuss implications for the physical conditions under which flares occur, and how the sample's metallicity and multiplicity affect our results.Comment: 17 pages, 11 figures, appendix. Accepted to A&

Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling.

Cells rely on the coordinated regulation of lipid phosphoinositides and Rab GTPases to define membrane compartment fates along distinct trafficking routes. The family of disease-related myotubularin (MTM) phosphoinositide phosphatases includes catalytically inactive members, or pseudophosphatases, with poorly understood functions. We found that Drosophila MTM pseudophosphatase Sbf coordinates both phosphatidylinositol 3-phosphate (PI(3)P) turnover and Rab21 GTPase activation in an endosomal pathway that controls macrophage remodeling. Sbf dynamically interacts with class II phosphatidylinositol 3-kinase and stably recruits Mtm to promote turnover of a PI(3)P subpool essential for endosomal trafficking. Sbf also functions as a guanine nucleotide exchange factor that promotes Rab21 GTPase activation associated with PI(3)P endosomes. Of importance, Sbf, Mtm, and Rab21 function together, along with Rab11-mediated endosomal trafficking, to control macrophage protrusion formation. This identifies Sbf as a critical coordinator of PI(3)P and Rab21 regulation, which specifies an endosomal pathway and cortical control