AC electric trapping of neutral atoms

We study the dynamic behavior of ultracold neutral atoms in a macroscopic ac electric trap. Confinement in such a trap is achieved by switching between two saddle-point configurations of the electric field. The gradual formation of a stably trapped cloud is observed and the trap performance is studied versus the switching frequency and the symmetry of the switching cycle. Additionally, the electric field in the trap is mapped out by imaging the atom cloud while the fields are still on. Finally, the phase-space acceptance of the trap is probed by introducing a modified switching cycle. The experimental results are reproduced using full three-dimensional trajectory calculations.Comment: 10 pages, 13 figures, updated version, added journal referenc

Trapping of Rb atoms by ac electric fields

We demonstrate trapping of an ultracold gas of neutral atoms in a macroscopic ac electric trap. Three-dimensional confinement is obtained by switching between two saddle-point configurations of the electric field. Stable trapping is observed in a narrow range of switching frequencies around 60 Hz. The dynamic confinement of the atoms is directly visualized at different phases of the ac switching cycle. We observe about 10^5 Rb atoms in the 1 mm^3 large and several microkelvins deep trap with a lifetime of approximately 5 s.Comment: 4 pages, 4 figures; updated version, added journal referenc

The efficacy of halofantrine in the treatment of acute malaria in nonimmune travelers

A multicenter prospective trial was performed to investigate the efficacy and the tolerability of halofantrine in nonimmune patients with malaria imported from areas with drug-resistant falciparum parasites (mainly Africa). Forty-five of the 74 subjects were treated with a one-day regimen (3 x 500 mg) of halofantrine, and the other 29 received the same regimen with an additional treatment on day 7. In the second group, a 100% efficacy rate was demonstrated, but in the group receiving the one-day regimen, four recrudescences were observed in patients with falciparum malaria. Only five mild adverse reactions were seen, which disappeared spontaneously after the end of the treatment. We conclude that halofantrine is highly effective in curing malaria in nonimmune subjects. The treatment scheme for such persons should include an additional treatment on day 7 for nonimmune individuals. This drug was well tolerated in our patients, indicating that halofantrine will be useful in the treatment of multidrug-resistant malaria in nonimmune persons

Experimental observation of high-order quantum accelerator modes.

Using a freely falling cloud of cold cesium atoms periodically kicked by pulses from a vertical standing wave of laser light, we present the first experimental observation of high-order quantum accelerator modes. This confirms the recent prediction by Fishman, Guarneri, and Rebuzzini [Phys. Rev. Lett.10.1103/PhysRevLett.89.084101 89, 084101 (2002)]. We also show how these accelerator modes can be identified with the stable regions of phase space in a classical-like chaotic system, despite their intrinsically quantum origin

Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice

Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH). Surprisingly, however, the assumption that tPA will worsen ICH has never been biologically tested. Here, we assessed the effects of tPA in two models of ICH. In a mouse model of collagenase-induced ICH, hemorrhage volumes and neurological deficits after 24 hrs were similar in saline controls and tPA-treated mice, whereas heparin-treated mice had 3-fold larger hematomas. In a model of laser-induced vessel rupture, tPA also did not worsen hemorrhage volumes, while heparin did. tPA is known to worsen neurovascular injury by amplifying matrix metalloproteinases during cerebral ischemia. In contrast, tPA did not upregulate matrix metalloproteinases in our mouse ICH models. In summary, our experimental data do not support the assumption that intravenous tPA has a deleterious effect in acute ICH. However, due to potential species differences and the inability of models to fully capture the dynamics of human ICH, caution is warranted when considering the implications of these findings for human therapy

The Zen of Corporate Capital Structure Neutrality

It is well understood that corporate capital structure affects tax collections. Most basically, corporate interest expense is deductible. With each interest accrual, the corporate tax base shrinks. Thus, there is a broad range of circumstances in which corporate managers are encouraged by the Internal Revenue Code (the Code ) to load their corporate capital structures with debt. But there is little support for the proposition that Conpress desires corporations to adopt such debt-laden capital structures. Indeed, much tax legislation suggests congressional displeasure with the achievable degree of corporate self- integration. On the other hand, corporate equity has its charms: shareholders are able to defer their gains essentially forever. Thus, in some circumstances the Code encourages corporate managers to load their corporate capital structures with equity. Based on the numerous provisions in the Code that depress the relative tax cost of equity, it is probably safe to conclude that Congress is more sanguine about equity than it is about debt. But periodically, Congress tempers its enthusiasm. And academicians as a group find the feature of equity deferral - the realization requirement - quite troubling

Little Boxes: Can Optimal Commodity Tax Methodology Save the Debt-Equity Distinction?

Optimal commodity tax methodology has been proposed as a way of making difficult line drawing decisions in the income tax. This paper explores some practical difficulties with the approach, and concludes that in one area - the debt-equity divide - the approach is unlikely to prove useful over any significant time horizon