343 research outputs found

    Evaluation of thermal indices for their applicability in obstacle-resolving meteorology models

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    A thermally comfortable design of outdoor spaces favors social interaction and outdoor activities and thus contributes to the overall well-being of urban dwellers. To assess such a design, obstacle-resolving models (ORM) combined with thermal indices may be used. This paper reviews existing thermal indices to identify those suitable for thermal comfort assessment with ORMs. For the identification, 11 criteria and six index features are derived from literature analysis focusing on the characteristics of human environmental heat exchange, of outdoor urban environments, and of ORMs. An air temperature weighted world population distribution is calculated to derive the minimal air temperature range; a thermal index should cover to be applicable to 95% of the world population. The criteria are applied to 165 thermal indices by reviewing their original publications. Results show that only four thermal indices are suitable to be applied globally in their current form to various outdoor urban environments and also fulfill the requirements of ORMs. The evaluation of the index features shows that they differ with respect to the comprehensiveness of the thermophysiological model, the assessed human response, the treatment of clothing and activity, and the computational costs. Furthermore, they differ in their total application frequency in past ORM studies and in their application frequency for different climatic zones, as a systematic literature analysis of thermal comfort studies employing ORMs showed. By depicting the differences of the thermal indices, this paper provides guidance to select an appropriate thermal index for thermal comfort studies with ORMs

    05/18/1993 - Eastern\u27s 1993 All Student Show Winner Laura Brahos.pdf

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    This paper reports on the stages forming a model evaluation protocol for urban flow and dispersion models proposed within the COST Action 732 on "Quality Assurance and Improvement of Micro-Scale Meteorological Models". It discusses the different components forming model evaluation with emphasis on validation and implementation of the protocol for the test case Mock Urban Setting Test (MUST). The protocol was proposed with building-resolving models in mind, but integral models have also been included. The suggested approach can be used for further micro-scale model evaluation and for the standardisation of their applications

    Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae

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    Mechanistic understanding of eukaryotic ribosome formation requires a detailed structural knowledge of the numerous assembly intermediates, generated along a complex pathway. Here, we present the structure of a late pre-40S particle at 3.6 Ă… resolution, revealing in molecular detail how assembly factors regulate the timely folding of pre-18S rRNA. The structure shows that, rather than sterically blocking 40S translational active sites, the associated assembly factors Tsr1, Enp1, Rio2 and Pno1 collectively preclude their final maturation, thereby preventing untimely tRNA and mRNA binding and error prone translation. Moreover, the structure explains how Pno1 coordinates the 3'end cleavage of the 18S rRNA by Nob1 and how the late factor's removal in the cytoplasm ensures the structural integrity of the maturing 40S subunit
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