Categories and Schemata

In this paper, I argue that once Kant has established his argument about the a priori transcendental ideality of Time, the objectivity of the Categories and their schematization can be established. If we remember that the Categories are not only concepts, but transcendental concepts, we will see that their objective nature is not as difficult to establish as if we were to consider them only as concepts as such. Further, once we understand the function of the Schematism and how Kant conceives of the Schemata, this will shed light as to the nature of the Categories themselves. Finally, I will propose an understanding of the relationship between the Categories and Schemata that will make a transcendental solution to the problem of the objectivity of the Categories and Schemata possible

No visitors allowed: How health systems can better engage patients’ families during a pandemic

The ravages of COVID -19 and the no visitor policies that accompany it have forged a tectonic shift in the patient and family experience. This hit home for me with a recent family member health event and hospitalization, leading me to think “we HAVE to do better!” Why should hospitals and health systems care about family involvement during COVID-19? Experience Framework This article is associated with the Patient, Family & Community Engagement lens of The Beryl Institute Experience Framework (https://www.theberylinstitute.org/ExperienceFramework). Access other PXJ articles related to this lens. Access other resources related to this lens

An Analysis of Performance-Based Perception in Competitive Baseball Players

Abstract: The correlation between performance hitting a baseball and perceived ball size has been described in previous work (Witt & Proffitt, 2005). The article in question used recreational softball players to demonstrate that greater performance led to a perceived change in softball size, but discussed a desire to replicate their experiment with competitive professionals. Using athletes from a semi-collegiate baseball team during their summer season, we were able to find a correlation that although weaker, continues to propagate the relationship found in previous studies. The finding of a weaker relationship also sheds new insight into why elite athletes may fare better at this task than their amateur counterparts

Evaluating variables of patient experience and the correlation with design

The objective of this paper was to understand the variables of patient experience by analyzing recent and relevant evidence and to identify design solutions within the hospital environment that positively impact those variables. A systematic review of literature published from 2008-present was conducted to identify variables that contribute to patient experience benefits. Identified variables were documented and categorized into a design, organizational, and outcome variable matrix. Interviews were conducted with professionals from healthcare institutions, architecture firms and organizations committed to improving the patient experience. Data from healthcare facilities, with high patient experience scores, was also examined to derive effective design solutions. The results showed patient engagement, satisfaction - patient and staff, clinical effectiveness, personalization, patient safety and, admission and discharge process were the variables that demonstrated a strong correlation with patient experience benefits. Analysis of the variables resulted in a range of design solutions, such as private and public interaction spaces, decentralized care models, designated staff areas etc. that could potentially improve the outcomes associated with each variable. This study illustrates that aspects of patient experience adopted before, during, and after the delivery of care have the ability to affect adherence, communication, and ultimately the relationship with the patient. It also shows that design of the physical space has a significant impact on the model of care and the overall experience of the patient and family

Quantum Simulation of Open Quantum Systems Using Density-Matrix Purification

Electronic structure and transport in realistically-sized systems often require an open quantum system (OQS) treatment, where the system is defined in the context of an environment. As OQS evolution is non-unitary, implementation on quantum computers -- limited to unitary operations -- is challenging. We present a general framework for OQSs where the system's $d \times d$ density matrix is recast as a $d^{2}$ wavefunction which can be evolved by unitary transformations. This theory has two significant advantages over conventional approaches: (i) the wavefunction requires only an $n$-qubit, compared to $2n$-qubit, bath for an $n$-qubit system and (ii) the purification includes dynamics of any pure-state universe. We demonstrate this method on a two-level system in a zero temperature amplitude damping channel and a two-site quantum Ising model. Quantum simulation and experimental-device results agree with classical calculations, showing promise in simulating non-unitary operations on NISQ quantum devices

The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress

The biological purpose of plant stem cells is to maintain themselves while providing new pools of differentiated cells that form organs and rejuvenate or replace damaged tissues. Protein homeostasis or proteostasis is required for cell function and viability. However, the link between proteostasis and plant stem cell identity remains unknown. In contrast to their differentiated counterparts, we find that root stem cells can prevent the accumulation of aggregated proteins even under proteotoxic stress conditions such as heat stress or proteasome inhibition. Notably, root stem cells exhibit enhanced expression of distinct chaperones that maintain proteome integrity. Particularly, intrinsic high levels of the T-complex protein-1 ring complex/chaperonin containing TCP1 (TRiC/CCT) complex determine stem cell maintenance and their remarkable ability to suppress protein aggregation. Overexpression of CCT8, a key activator of TRiC/CCT assembly, is sufficient to ameliorate protein aggregation in differentiated cells and confer resistance to proteotoxic stress in plants. Taken together, our results indicate that enhanced proteostasis mechanisms in stem cells could be an important requirement for plants to persist under extreme environmental conditions and reach extreme long ages. Thus, proteostasis of stem cells can provide insights to design and breed plants tolerant to environmental challenges caused by the climate change

In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation

In humans, aggregation of polyglutamine repeat (polyQ) proteins causes disorders such as Huntington’s disease. Although plants express hundreds of polyQ-containing proteins, no pathologies arising from polyQ aggregation have been reported. To investigate this phenomenon, we expressed an aggregation-prone fragment of human huntingtin (HTT) with an expanded polyQ stretch (Q69) in Arabidopsis thaliana plants. In contrast to animal models, we find that Arabidopsis sp. suppresses Q69 aggregation through chloroplast proteostasis. Inhibition of chloroplast proteostasis diminishes the capacity of plants to prevent cytosolic Q69 aggregation. Moreover, endogenous polyQ-containing proteins also aggregate on chloroplast dysfunction. We find tha