136 research outputs found
An agent-based approach to assess drivers’ interaction with pre-trip information systems.
This article reports on the practical use of a multi-agent microsimulation framework to address the issue of assessing drivers’
responses to pretrip information systems. The population of drivers is represented as a community of autonomous agents,
and travel demand results from the decision-making deliberation performed by each individual of the population as regards
route and departure time. A simple simulation scenario was devised, where pretrip information was made available to users
on an individual basis so that its effects at the aggregate level could be observed. The simulation results show that the
overall performance of the system is very likely affected by exogenous information, and these results are ascribed to demand
formation and network topology. The expressiveness offered by cognitive approaches based on predicate logics, such as the
one used in this research, appears to be a promising approximation to fostering more complex behavior modelling, allowing
us to represent many of the mental aspects involved in the deliberation process
Specialized interfaces of Smc5/6 control hinge stability and DNA association
The Structural Maintenance of Chromosomes (SMC) complexes: cohesin, condensin and Smc5/6 are involved in the organization of higher-order chromosome structure—which is essential for accurate chromosome duplication and segregation. Each complex is scaffolded by a specific SMC protein dimer (heterodimer in eukaryotes) held together via their hinge domains. Here we show that the Smc5/6-hinge, like those of cohesin and condensin, also forms a toroidal structure but with distinctive subunit interfaces absent from the other SMC complexes; an unusual ‘molecular latch’ and a functional ‘hub’. Defined mutations in these interfaces cause severe phenotypic effects with sensitivity to DNA-damaging agents in fission yeast and reduced viability in human cells. We show that the Smc5/6-hinge complex binds preferentially to ssDNA and that this interaction is affected by both ‘latch’ and ‘hub’ mutations, suggesting a key role for these unique features in controlling DNA association by the Smc5/6 complex
Combinatorial Activation and Repression by Seven Transcription Factors Specify Drosophila Odorant Receptor Expression
A systematic analysis reveals a regulatory network controlling selective odorant receptor expression and neuronal diversity in Drosophila
Cohesion proteins are present in centromere protein bodies associated with avian lampbrush chromosomes
Wirkungsmessung pädagogischer Interventionen: Anpassung eines Zielerreichungsinstruments an jugendforensische Anforderungen
The Influence of Low Doses of Zearalenone on Distribution of Selected Active Substances in Nerve Fibers Within the Circular Muscle Layer of Porcine Ileum
The MukF subunit of Escherichia coli condensin: architecture and functional relationship to kleisins
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