Terahertz local oscillator sources: performance and capabilities

Frequency multiplier circuits based on planar GaAs Schottky diodes have advanced significantly in the last decade. Useful power in the >1 THz range has now been demonstrated from a complete solid-state chain. This paper will review some of the technologies that have led to this achievement along with a brief look at future challenges

How to feed the cities? Co-creating inclusive, healthy and sustainable city region food systems

People drive transitions. Current urban living conditions, specifically food systems, challenge the health, wellbeing and coherence of individuals and whole societies, and for effective change toward resilient communities, people need to reinvent the way they produce, distribute and consume food. Consequently, in their communities' people are creating foodscapes and governing the transition toward sustainable local food systems. Here, we introduce a conceptual framework to develop this transformation through empowering the urban multi-stakeholder society as the agent of this process. To do so, we reviewed scientific evidence and experiences from seven selected City Regions (Albacete, Baku, Dresden, Izmir, Ljubljana, Megara, and Valparaiso) as case studies and conducted a SWOT analysis to explore the capacity of food systems to enhance multi-functionality of urban landscapes, with special focus on social cohesion and quality of life. We grasp existing policies; hone them and leverage policies and strategies toward human-centered actions for future proofing food systems.Peer Reviewe

Towards Conservation of Omani Local Chicken: Phenotypic Characteristics, Management Practices and Performance Traits

Characterizing local chicken types and their mostly rural production systems is prerequisite for designing and implementing development and conservation programs. This study evaluated the management practices of small-scale chicken keepers and the phenotypic and production traits of their chickens in Oman, where conservation programs for local livestock breeds have currently started. Free-range scavenging was the dominant production system, and logistic regression analysis showed that socio-economic factors such as training in poultry keeping, household income, income from farming and gender of chicken owners influenced feeding, housing, and health care practices (p<0.05). A large variation in plumage and shank colors, comb types and other phenotypic traits within and between Omani chicken populations were observed. Male and female body weight differed (p<0.05), being 1.3±0.65 kg and 1.1±0.86 kg respectively. Flock size averaged 22±7.7 birds per household with 4.8 hens per cock. Clutch size was 12.3±2.85 and annual production 64.5±2.85 eggs per hen. Egg hatchability averaged 88±6.0% and annual chicken mortality across all age and sex categories was 16±1.4%. The strong involvement of women in chicken keeping makes them key stakeholders in future development and conservation programs, but the latter should be preceded by a comprehensive study of the genetic diversity of the Omani chicken populations

A comparison between urban livestock production strategies in Burkina Faso, Mali and Nigeria in West Africa

We undertook a comparative analysis of (peri-)urban livestock production strategies across three West African cities. Using a semi-structured questionnaire, livestock-keeping households (HH) were interviewed in Kano/Nigeria (84 HH), Bobo Dioulasso/Burkina Faso (63 HH) and Sikasso/Mali (63 HH). Questions covered livestock species kept, herd sizes and structure, feeds used, manure management, livestock marketing and production constraints. Sheep and goats dominated (p¿¿0.05), but the proportion of HH heads with a long-term experience in UPA activities was higher in Kano and in Bobo Dioulasso than in Sikasso (p

On-Chip Power-Combining for High-Power Schottky Diode-Based Frequency Multipliers

A 1.6-THz power-combined Schottky frequency tripler was designed to handle approximately 30 mW input power. The design of Schottky-based triplers at this frequency range is mainly constrained by the shrinkage of the waveguide dimensions with frequency and the minimum diode mesa sizes, which limits the maximum number of diodes that can be placed on the chip to no more than two. Hence, multiple-chip power-combined schemes become necessary to increase the power-handling capabilities of high-frequency multipliers. The design presented here overcomes difficulties by performing the power-combining directly on-chip. Four E-probes are located at a single input waveguide in order to equally pump four multiplying structures (featuring two diodes each). The produced output power is then recombined at the output using the same concept

Effects of cardiomyopathy-linked mutations K15N and R21H in tropomyosin on thin-filament regulation and pointed-end dynamics

Missense mutations K15N and R21H in striated muscle tropomyosin are linked to dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), respectively. Tropomyosin, together with the troponin complex, regulates muscle contraction and, along with tropomodulin and leiomodin, controls the uniform thin-filament lengths crucial for normal sarcomere structure and function. We used Förster resonance energy transfer to study effects of the tropomyosin mutations on the structure and kinetics of the cardiac troponin core domain associated with the Ca2+-dependent regulation of cardiac thin filaments. We found that the K15N mutation desensitizes thin filaments to Ca2+ and slows the kinetics of structural changes in troponin induced by Ca2+ dissociation from troponin, while the R21H mutation has almost no effect on these parameters. Expression of the K15N mutant in cardiomyocytes decreases leiomodin’s thin-filament pointed-end assembly but does not affect tropomodulin’s assembly at the pointed end. Our in vitro assays show that the R21H mutation causes a twofold decrease in tropomyosin’s affinity for F-actin and affects leiomodin’s function. We suggest that the K15N mutation causes DCM by altering Ca2+-dependent thin-filament regulation and that one of the possible HCM-causing mechanisms by the R21H mutation is through alteration of leiomodin’s function