1,103 research outputs found

    DN4 PHARMACOECONONOMIC EVALUATION OF SEDATION WITH REMIFENTANIL/PROPOFOLVERSUS MIDAZOLAM/FENTANYL IN THE INTENSIVE CARE UNIT

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    Environmental behaviours within ecological and social limits: integrating well-being with behavioural research for sustainability

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    This is the final version. Available from Elsevier via the DOI in this record. There is a pressing need to reduce inequalities and bring everyone above a foundational level of well-being whilst simultaneously staying within planetary boundaries. Yet, there is a limited understanding of how moving into and maintaining such 'safe and just' spaces affect environmental behaviours. To fill this gap, we argue for integrating human well-being and behaviour research. In particular, to 1) implement social thresholds when investigating environmental behaviours; 2) investigate the impact of social inequalities on environmental behaviours directly and 3) incorporate well-being domains with controlled behavioural experiments. Such understandings will be crucial for anticipating the implications of realising safe and just spaces for people and the planet.Swedish Research Council for Sustainable Development (Formas)Beijer Foundatio

    Freestanding metasurfaces for optical frequencies

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    We present freestanding metasurfaces operating at optical frequencies with a total thickness of only 40 \,nm. The metasurfaces are fabricated by focused ion beam milling of nanovoids in a carbon film followed by thermal evaporation of gold and plasma ashing of the carbon film. As a first example, we demonstrate a metasurface lens based on resonant V-shaped nanovoids with a focal length of 1 \,mm. The second example is a metasurface phase-plate consisting of appropriately oriented rectangular nanovoids that transforms a Gaussian input beam into a Laguerre-Gaussian LG−1,0{LG_{-1,0}} mode

    Criteria and geological setting for the generic geothermal underground research laboratory, GEOLAB

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    High flow rate injection and related hydromechanical interaction are the most important factors in reservoir development of Enhanced Geothermal Systems (EGS). GeoLaB, a new generic geothermal underground research laboratory (URL), is proposed for controlled high flow rate experiments (CHFE) to address limited comprehension of coupled processes connected to EGS reservoir flow conditions. As analogue for typical EGS development, CHFE require specific hydromechanical conditions including a connected fracture network in crystalline basement rock, sufficient hydraulic fracture transmissivities, a strike-slip to normal faulting tectonic regime, controllable hydraulic boundary conditions, and hydrothermal alteration fracture fillings that improve conditions for hydromechanical interaction. With the aim to identify most appropriate areas for future site selection, four criteria have been established based on the EGS reference site of Soultz. Two URLs in crystalline basement worldwide approximate the requirements of a new generic GeoLaB and may be used for accompanying experimentation. Besides favourable geological, hydraulic, and stress conditions, the vicinity to long-term EGS production favours the southern Black Forest as potential region for GeoLaB. Therefore, an exemplary site assessment has been carried out at “Wilhelminenstollen” in the southern Black Forest (Germany). New remote sensing, hydrochemical, and geophysical analyses as well as reactivation potential, and stress modelling were added to complement existing geological and hydrogeological information. At this site, reactivation potential analysis reveals two local maxima prone for shear reactivation as strike-slip faults. The highest lineament density is observed for the N110°E strike direction that is associated with both slip and dilation tendency maxima. Clay minerals occur in fractures and the matrix. Local, partly water-bearing fractures, when partly filled with ore minerals, were connected to veins in the tunnel using shallow geophysical methods. Hydrochemical data reveal infiltration of the tunnel water from at least 500 m above the tunnel. The results suggest a crystalline basement with a fracture network that is regionally connected and water-conducting. Hydraulic conductivity in the southern Black Forest granite is estimated to amount to about 4.5·10−8 m s−1 at 500 m depth. The hydraulic boundary conditions exclude unknown drainage. Analyses of the influence of topography on orientation and magnitude of the maximum stress indicate a minimum overburden of about 500 m for regional reactivation to be valid. In conclusion, the southern Black Forest and in particular “Wilhelminenstollen” offers favourable condition for CHFE. Final decision on the GeoLaB site is to be drawn from forthcoming exploration wells

    Integrated pathway modules using time-course metabolic profiles and EST data from Milnesium tardigradum

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    <p>Abstract</p> <p>Background</p> <p>Tardigrades are multicellular organisms, resistant to extreme environmental changes such as heat, drought, radiation and freezing. They outlast these conditions in an inactive form (tun) to escape damage to cellular structures and cell death. Tardigrades are apparently able to prevent or repair such damage and are therefore a crucial model organism for stress tolerance. Cultures of the tardigrade <it>Milnesium tardigradum</it> were dehydrated by removing the surrounding water to induce tun formation. During this process and the subsequent rehydration, metabolites were measured in a time series by GC-MS. Additionally expressed sequence tags are available, especially libraries generated from the active and inactive state. The aim of this integrated analysis is to trace changes in tardigrade metabolism and identify pathways responsible for their extreme resistance against physical stress.</p> <p>Results</p> <p>In this study we propose a novel integrative approach for the analysis of metabolic networks to identify modules of joint shifts on the transcriptomic and metabolic levels. We derive a tardigrade-specific metabolic network represented as an undirected graph with 3,658 nodes (metabolites) and 4,378 edges (reactions). Time course metabolite profiles are used to score the network nodes showing a significant change over time. The edges are scored according to information on enzymes from the EST data. Using this combined information, we identify a key subnetwork (functional module) of concerted changes in metabolic pathways, specific for de- and rehydration. The module is enriched in reactions showing significant changes in metabolite levels and enzyme abundance during the transition. It resembles the cessation of a measurable metabolism (e.g. glycolysis and amino acid anabolism) during the tun formation, the production of storage metabolites and bioprotectants, such as DNA stabilizers, and the generation of amino acids and cellular components from monosaccharides as carbon and energy source during rehydration.</p> <p>Conclusions</p> <p>The functional module identifies relationships among changed metabolites (e.g. spermidine) and reactions and provides first insights into important altered metabolic pathways. With sparse and diverse data available, the presented integrated metabolite network approach is suitable to integrate all existing data and analyse it in a combined manner.</p

    From local watershed management to integrated river basin management at national and transboundary levels

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    Watersheds face a range of degradation challenges associated with human activities, such as pollution, deforestation and changes in sediment generation. The way they are managed has a profound cascading effect on natural resources and communities in the wider basin. Although watersheds play a critical role as the basic hydrological unit within a river basin they are often neglected in river basin management. Over the past decade, principles and practices have evolved to ensure that integrated water resources management (IWRM) approaches used at the broader basin level to address sustainable development and management of land and water resources also apply at the smaller watershed level. This technical report is a synthesis of the knowledge, lessons learned and good practices presented and discussed at the International Conference on Watershed Management held in Chiang Mai, Thailand 9-11 March 2011

    Hydrochemical characterisation of a Major central European heat flux anomaly: the BĂźrchau geothermal spring system, Southern Black Forest, Germany

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    Background: The possible signature of deep fluids originating from processes occurring during infiltration or circulation in a remote valley in the Black Forest (Germany), a typical infiltration area in the crystalline basement which represents a possible recharge zone of one of the major heat flux density anomalies in central Europe, has been hydrochemically characterised. Chemical and isotopic compositions of two warm springs and several cold springs in Bürchau as well as water from the Badenweiler Spa were sampled three times during June and October 2013. Methods: A number of 70 water samples were taken at natural outlet conditions and analysed for major and trace elements, water H/O-isotope ratios and sulphur isotope ratios of dissolved sulfate. A chlorofluorocarbon (CFC) analysis was conducted to determine the underground residence time of the thermal water. To assess water-rock interactions seven rock samples representing the occurring lithological units of the study area were prepared to thin sections for polarization microscopic analysis. Results: The main spring in Bürchau discharging water with a temperature up to T = 18.1°C at flow rates of approximately 0.2 L s−1^{-1} is Na-Ca-HCO3_{3}-dominated and generally low mineralised (total dissolved solids (TDS) of about 150 mg L−1^{-1}). Even lower mineralisation and temperature of a nearby spring indicates further dilution with shallow groundwater. With respect to cold springs in the vicinity, the thermal water in Bürchau is slightly enriched in Cl, B, Li, Rb and Cs. In nearby granites, sericitisation of plagioclase and oxidation of pyrite to goethite have been identified. The stable isotope composition of H and O suggests meteoric origin of the water. Chlorofluorocarbon (CFC) analyses indicate that 30% to 40% of the thermal water in Bürchau is younger than 60 to 70 years. Reservoir temperatures have been estimated to 40°C to 80°C using sulphate and quartz geothermometers. Conclusions: Thus, the circulation time of the other 60% to 70% of the thermal water is longer than 70 years. Estimated reservoir temperatures in a range of 40°C to 80°C correspond to an infiltration depth of about 1,600 to 1,800 m
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