Lutz Rathenow: Die lautere Bosheit.

Remchingen: Maulwurf, 1992. 128 p

Utz Rachowski: Namenlose

Berlin: BasisDruck, 1993. 196 p

Marine vertebrates from the Santonian coastal carbonates ofnorthwestern Germany – a tool for the reconstruction of a Proto-North Sea Basin intertidal dinosaur-exchange bridge

A diverse vertebrate fauna, dominated by sharkteeth, is recorded from conglomerates within the limestonesof the Upper Cretaceous (Santonian) BurgsteinfurtFormation of northwestern Germany. The conglomeratebeds comprise carbonatic, glauconitic and phosphatenodules, as well as Triassic, Jurassic and Cretaceous extraclasts.The Burgsteinfurt Formation conglomerates containfining-upwards parasequences 2–20 cm in thickness,interpreted as tempestite layers within a unit formed bylarger-scale Milankovitch Cycles. The presence of the inoceramidSphenoceramus patootensis and belemnite Gonioteuthisgranulata indicate a late Santonian age for theunit. The studied vertebrate fauna from the Weiner Eschlocality consists of 20 selachian species (14 macroselachiansand 6 microselachians), a few teleosts, rare marinemosasaur remains, and one tooth from a theropod dinosaur.95% of the vertebrates in the assemblage are depositionallyautochthonous, with the remaining materialreworked from older underlying Cenomanian–Coniacian(lower Upper Cretaceous) limestones. On the basis of observedsedimentary structures, the scarcity of deep-seaselachians, and the dominance of the Mitsukurinidae(59% of the preserved shark fauna) in the fossil assemblage,the unit is interpreted as a shallow (0–3 metresdeep), subtidal, nearshore environment, or even subaerialcarbonate-sand islands, located on the southern marginof a submarine swell. The presence of a Santonian theropodin this deposit, and other dinosaur records in northernGermany, together support the interpretation of ashort-lived uplift event with strong upwelling influence forthe Northwestphalian-Lippe submarine swell north of theRhenish Massif in the southern Proto- North Sea Basin. Anew migration model for dinosaurs moving along carbonatecoasts or intertidal zones of shallow carbonate-sand islandsin Central Europe is presented, which may explainthe scattered distribution of dinosaur remains across Europein the Upper Cretaceous

Virtuelle Bildungsnetzwerke: Struktur- und Betreibermodelle am Beispiel WINFOLine

Dieser Beitrag beschäftigt sich mit Struktur- und Betreibermodellen virtueller Bildungsnetzwerke. Er verdeutlicht Potenziale und Anforderungen beim Aufbau entsprechender Strukturen und betrachtet allgemein den Wertschöpfungsprozess von Bildungsnetzwerken, aus dem spezifische Betreibermodelle abgeleitet werden können. Dabei spielt die Betrachtung einzelner Partner von Bildungsnetzwerken und ihrer spezifischen Aufgaben innerhalb von Verbünden eine ebenso wichtige Rolle wie die Betrachtung potenzieller Abnehmer von Bildungsangeboten. Vertiefend werden in diesem Beitrag Ansätze der traditionellen Hochschulen diskutiert

Virtuelle Bildungsnetzwerke: Struktur- und Betreibermodelle am Beispiel WINFOLine

Dieser Beitrag beschäftigt sich mit Struktur- und Betreibermodellen virtueller Bildungsnetzwerke. Er verdeutlicht Potenziale und Anforderungen beim Aufbau entsprechender Strukturen und betrachtet allgemein den Wertschöpfungsprozess von Bildungsnetzwerken, aus dem spezifische Betreibermodelle abgeleitet werden können. Dabei spielt die Betrachtung einzelner Partner von Bildungsnetzwerken und ihrer spezifischen Aufgaben innerhalb von Verbünden eine ebenso wichtige Rolle wie die Betrachtung potenzieller Abnehmer von Bildungsangeboten. Vertiefend werden in diesem Beitrag Ansätze der traditionellen Hochschulen diskutiert

Prospective Evaluation of CD45RA+/CCR7- Effector Memory T (TEMRA) Cell Subsets in Patients with Primary and Secondary Brain Tumors during Radiotherapy of the Brain within the Scope of the Prospective Glio-CMV-01 Clinical Trial

Radiotherapy (RT) of the brain is a common treatment for patients with high-grade gliomas and brain metastases. It has previously been shown that reactivation of cytomegalovirus (CMV) frequently occurs during RT of the brain. This causes neurological decline, demands antiviral treatment, and is associated with a worse prognosis. CMV-specific T cells are characterized by a differentiated effector memory phenotype and CD45RA+ CCR7- effector memory T (TEMRA) cells were shown to be enriched in CMV seropositive individuals. In this study, we investigated the distribution of TEMRA cells and their subsets in the peripheral blood of healthy donors and, for the first time, prospectively within the scope of the prospective Glio-CMV-01 clinical trial of patients with high-grade glioma and brain metastases during radiation therapy as a potential predictive marker. First, we developed a multicolor flow cytometry-based assay to monitor the frequency and distribution of TEMRA cells in a longitudinal manner. The CMV serostatus and age were considered as influencing factors. We revealed that patients who had a reactivation of CMV have significantly higher amounts of CD8+ TEMRA cells. Further, the distribution of the subsets of TEMRA cells based on the expression of CD27, CD28, and CD57 is highly dependent on the CMV serostatus. We conclude that the percentage of CD8+ TEMRA cells out of all CD8+ T cells has the potential to serve as a biomarker for predicting the risk of CMV reactivation during RT of the brain. Furthermore, this study highlights the importance of taking the CMV serostatus into account when analyzing TEMRA cells and their subsets

Prospective Evaluation of CD45RA+/CCR7- Effector Memory T (T_EMRA) Cell Subsets in Patients with Primary and Secondary Brain Tumors during Radiotherapy of the Brain within the Scope of the Prospective Glio-CMV-01 Clinical Trial

Radiotherapy (RT) of the brain is a common treatment for patients with high-grade gliomas and brain metastases. It has previously been shown that reactivation of cytomegalovirus (CMV) frequently occurs during RT of the brain. This causes neurological decline, demands antiviral treatment, and is associated with a worse prognosis. CMV-specific T cells are characterized by a differentiated effector memory phenotype and CD45RA+ CCR7- effector memory T (TEMRA) cells were shown to be enriched in CMV seropositive individuals. In this study, we investigated the distribution of TEMRA cells and their subsets in the peripheral blood of healthy donors and, for the first time, prospectively within the scope of the prospective Glio-CMV-01 clinical trial of patients with high-grade glioma and brain metastases during radiation therapy as a potential predictive marker. First, we developed a multicolor flow cytometry-based assay to monitor the frequency and distribution of TEMRA cells in a longitudinal manner. The CMV serostatus and age were considered as influencing factors. We revealed that patients who had a reactivation of CMV have significantly higher amounts of CD8+ TEMRA cells. Further, the distribution of the subsets of TEMRA cells based on the expression of CD27, CD28, and CD57 is highly dependent on the CMV serostatus. We conclude that the percentage of CD8+ TEMRA cells out of all CD8+ T cells has the potential to serve as a biomarker for predicting the risk of CMV reactivation during RT of the brain. Furthermore, this study highlights the importance of taking the CMV serostatus into account when analyzing TEMRA cells and their subsets