121 research outputs found
Kinematic Effects in Radiative Quarkonia Decays
Non-relativistic QCD (NRQCD) predicts colour octet contributions to be
significant not only in many production processes of heavy quarkonia but also
in their radiative decays. We investigate the photon energy distributions in
these processes in the endpoint region. There the velocity expansion of NRQCD
breaks down which requires a resummation of an infinite class of colour octet
operators to so-called shape functions. We model these non-perturbative
functions by the emission of a soft gluon cluster in the initial state. We
found that the spectrum in the endpoint region is poorly understood if the
values for the colour octet matrix elements are taken as large as indicated
from NRQCD scaling rules. Therefore the endpoint region should not be taken
into account for a fit of the strong coupling constant at the scale of the
heavy quark mass.Comment: LaTeX, 17 pages, 5 figures. The complete paper is also available via
the www at http://www-ttp.physik.uni-karlsruhe.de/Preprints
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease
Human middle temporal gyrus (MTG) is a vulnerable brain region in early Alzheimer’s disease (AD), but little is known about the molecular mechanisms underlying this regional vulnerability. Here we utilize the 10 × Visium platform to define the spatial transcriptomic profile in both AD and control (CT) MTG. We identify unique marker genes for cortical layers and the white matter, and layer-specific differentially expressed genes (DEGs) in human AD compared to CT. Deconvolution of the Visium spots showcases the significant difference in particular cell types among cortical layers and the white matter. Gene co-expression analyses reveal eight gene modules, four of which have significantly altered co-expression patterns in the presence of AD pathology. The co-expression patterns of hub genes and enriched pathways in the presence of AD pathology indicate an important role of cell–cell-communications among microglia, oligodendrocytes, astrocytes, and neurons, which may contribute to the cellular and regional vulnerability in early AD. Using single-molecule fluorescent in situ hybridization, we validated the cell-type-specific expression of three novel DEGs (e.g., KIF5A, PAQR6, and SLC1A3) and eleven previously reported DEGs associated with AD pathology (i.e., amyloid beta plaques and intraneuronal neurofibrillary tangles or neuropil threads) at the single cell level. Our results may contribute to the understanding of the complex architecture and neuronal and glial response to AD pathology of this vulnerable brain region
Radiative Decays of the Upsilon(1S) to a Pair of Charged Hadrons
Using data obtained with the CLEO~III detector, running at the Cornell
Electron Storage Ring (CESR), we report on a new study of exclusive radiative
Upsilon(1S) decays into the final states gamma pi^+ pi^-, gamma K^+ K^-, and
gamma p pbar.. We present branching ratio measurements for the decay modes
Upsilon(1S) to gamma f_2(1270), Upsilon(1S) to gamma f_2'(1525), and
Upsilon(1S) to gamma K^+K^-; helicity production ratios for f_2(1270) and
f_2'(1525); upper limits for the decay Upsilon(1S) to gamma f_J(2200), with
f_J(2220) to pi^+ pi^-, K^+ K^-, p pbar; and an upper limit for the decay
Upsilon(1S) to gamma X(1860), with X(1860) to gamma p pbar.Comment: 17 pages postscript,also available through
http://www.lns.cornell.edu/public/CLNS/2005/, Submitted to PR
A Phenomenological Analysis of Gluon Mass Effects in Inclusive Radiative Decays of the and $\Upsilon
The shapes of the inclusive photon spectra in the processes \Jp \to \gamma
X and \Up \to \gamma X have been analysed using all available experimental
data.
Relativistic, higher order QCD and gluon mass corrections were taken into
account in the fitted functions. Only on including the gluon mass corrections,
were consistent and acceptable fits obtained. Values of
GeV and GeV were found for the
effective gluon masses (corresponding to Born level diagrams) for the \Jp and
\Up respectively. The width ratios \Gamma(V \to {\rm hadrons})/\Gamma(V \to
\gamma+ {\rm hadrons}) V=\Jp, \Up were used to determine and . Values consistent with the current world
average were obtained only when gluon mass correction factors,
calculated using the fitted values of the effective gluon mass, were applied. A
gluon mass GeV, as suggested with these results, is consistent with
previous analytical theoretical calculations and independent phenomenological
estimates, as well as with a recent, more accurate, lattice calculation of the
gluon propagator in the infra-red region.Comment: 50 pages, 11 figures, 15 table
The integration of occlusion and disparity information for judging depth in autism spectrum disorder
In autism spectrum disorder (ASD), atypical integration of visual depth cues may be due to flattened perceptual priors or selective fusion. The current study attempts to disentangle these explanations by psychophysically assessing within-modality integration of ordinal (occlusion) and metric (disparity) depth cues while accounting for sensitivity to stereoscopic information. Participants included 22 individuals with ASD and 23 typically developing matched controls. Although adults with ASD were found to have significantly poorer stereoacuity, they were still able to automatically integrate conflicting depth cues, lending support to the idea that priors are intact in ASD. However, dissimilarities in response speed variability between the ASD and TD groups suggests that there may be differences in the perceptual decision-making aspect of the task
Light Meson Spectroscopy
We survey the current status of light meson spectroscopy. We begin with a
general introduction to meson spectroscopy and and its importance in
understanding the physical states of Quantum Chromo Dynamics (QCD).
Phemenological models of hadron spectroscopy are described with particular
emphasis on the constituent quark model and the qualitative features it
predicts for the meson spectrum. We next discuss expectations for hadrons lying
outside the quark model, such as hadron states with excited gluonic degrees of
freedom. These states include so-called hybrids glueballs}, as well as
multiquark states. The established meson states are compared to the quark model
predictions and we find that most meson states are well described by the quark
model. However, a number of states in the light-quark sector do not fit in
well, suggesting the existence of hadronic states with additional degrees of
freedom. We end with a brief description of future directions in meson
spectroscopy.Comment: 111 pages with 28 imbedded figures, in LaTeX2e with no special
macros. Submitted to Reviews of Modern Physics, Nov.12, 199
Proton-Antiproton Annihilation and Meson Spectroscopy with the Crystal Barrel
This report reviews the achievements of the Crystal Barrel experiment at the
Low Energy Antiproton Ring (LEAR) at CERN. During seven years of operation
Crystal Barrel has collected very large statistical samples in pbarp
annihilation, especially at rest and with emphasis on final states with high
neutral multiplicity. The measured rates for annihilation into various two-body
channels and for electromagnetic processes have been used to test simple models
for the annihilation mechanism based on the quark internal structure of
hadrons. From three-body annihilations three scalar mesons, a0(1450), f0(1370)
and f0(1500) have been established in various decay modes. One of them,
f0(1500), may be identified with the expected ground state scalar glueball.Comment: 64 pages, LATEX file, 36 figures are available as ps files at
http://afuz01.cern.ch/claude/ Submitted to Reviews of Modern Physic
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume
The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer’s Disease (AD). Whilst studies have reported associations with AD risk and related phenotypes, there remains a lack of consensus on these associations. Here we aimed to comprehensively investigate the relationship between five recognised measures of age acceleration, based on DNA methylation patterns (DNAm age), and cross-sectional and longitudinal cognition and AD-related neuroimaging phenotypes (volumetric MRI and Amyloid-β PET) in the Australian Imaging, Biomarkers and Lifestyle (AIBL) and the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Significant associations were observed between age acceleration using the Hannum epigenetic clock and cross-sectional hippocampal volume in AIBL and replicated in ADNI. In AIBL, several other findings were observed cross-sectionally, including a significant association between hippocampal volume and the Hannum and Phenoage epigenetic clocks. Further, significant associations were also observed between hippocampal volume and the Zhang and Phenoage epigenetic clocks within Amyloid-β positive individuals. However, these were not validated within the ADNI cohort. No associations between age acceleration and other Alzheimer’s disease-related phenotypes, including measures of cognition or brain Amyloid-β burden, were observed, and there was no association with longitudinal change in any phenotype. This study presents a link between age acceleration, as determined using DNA methylation, and hippocampal volume that was statistically significant across two highly characterised cohorts. The results presented in this study contribute to a growing literature that supports the role of epigenetic modifications in ageing and AD-related phenotypes
The Confrontation between General Relativity and Experiment
The status of experimental tests of general relativity and of theoretical
frameworks for analysing them is reviewed. Einstein's equivalence principle
(EEP) is well supported by experiments such as the Eotvos experiment, tests of
special relativity, and the gravitational redshift experiment. Future tests of
EEP and of the inverse square law are searching for new interactions arising
from unification or quantum gravity. Tests of general relativity at the
post-Newtonian level have reached high precision, including the light
deflection, the Shapiro time delay, the perihelion advance of Mercury, and the
Nordtvedt effect in lunar motion. Gravitational-wave damping has been detected
in an amount that agrees with general relativity to better than half a percent
using the Hulse-Taylor binary pulsar, and other binary pulsar systems have
yielded other tests, especially of strong-field effects. When direct
observation of gravitational radiation from astrophysical sources begins, new
tests of general relativity will be possible.Comment: 89 pages, 8 figures; an update of the Living Review article
originally published in 2001; final published version incorporating referees'
suggestion
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