107 research outputs found
Modelling and analysis of planar cell polarity
Planar cell polarity (PCP) occurs in the epithelia of many animals and can lead to the alignment of hairs, bristles and feathers; physiologically, it can organise ciliary beating. Here we present two approaches to modelling this phenomenon. The aim is to discover the basic mechanisms that drive PCP, while keeping the models mathematically tractable. We present a feedback and diffusion model, in which adjacent cell sides of neighbouring cells are coupled by a negative feedback loop and diffusion acts within the cell. This approach can give rise to polarity, but also to period two patterns. Polarisation arises via an instability provided a sufficiently strong feedback and sufficiently weak diffusion. Moreover, we discuss a conservative model in which proteins within a cell are redistributed depending on the amount of proteins in the neighbouring cells, coupled with intracellular diffusion. In this case polarity can arise from weakly polarised initial conditions or via a wave provided the diffusion is weak enough. Both models can overcome small anomalies in the initial conditions. Furthermore, the range of the effects of groups of cells with different properties than the surrounding cells depends on the strength of the initial global cue and the intracellular diffusion
Automatic Sound Event Detection and Classification of Great Ape Calls Using Neural Networks
We present a novel approach to automatically detect and classify great ape
calls from continuous raw audio recordings collected during field research. Our
method leverages deep pretrained and sequential neural networks, including
wav2vec 2.0 and LSTM, and is validated on three data sets from three different
great ape lineages (orangutans, chimpanzees, and bonobos). The recordings were
collected by different researchers and include different annotation schemes,
which our pipeline preprocesses and trains in a uniform fashion. Our results
for call detection and classification attain high accuracy. Our method is aimed
to be generalizable to other animal species, and more generally, sound event
detection tasks. To foster future research, we make our pipeline and methods
publicly available.Comment: Accepted at ICPhS 2023 (Poster
Modelling and analysis of planar cell polarity
Planar cell polarity (PCP) occurs in the epithelia of many animals and can lead to the alignment of hairs, bristles and feathers; physiologically, it can organise ciliary beating. Here we present two approaches to modelling this phenomenon. The aim is to discover the basic mechanisms that drive PCP, while keeping the models mathematically tractable. We present a feedback and diffusion model, in which adjacent cell sides of neighbouring cells are coupled by a negative feedback loop and diffusion acts within the cell. This approach can give rise to polarity, but also to period two patterns. Polarisation arises via an instability provided a sufficiently strong feedback and sufficiently weak diffusion. Moreover, we discuss a conservative model in which proteins within a cell are redistributed depending on the amount of proteins in the neighbouring cells, coupled with intracellular diffusion. In this case polarity can arise from weakly polarised initial conditions or via a wave provided the diffusion is weak enough. Both models can overcome small anomalies in the initial conditions. Furthermore, the range of the effects of groups of cells with different properties than the surrounding cells depends on the strength of the initial global cue and the intracellular diffusion
Test of Information Theory on the Boltzmann Equation
We examine information theory using the steady-state Boltzmann equation. In a
nonequilibrium steady-state system under steady heat conduction, the
thermodynamic quantities from information theory are calculated and compared
with those from the steady-state Boltzmann equation. We have found that
information theory is inconsistent with the steady-state Boltzmann equation.Comment: 12 page
Kinetic Theory of a Dilute Gas System under Steady Heat Conduction
The velocity distribution function of the steady-state Boltzmann equation for
hard-core molecules in the presence of a temperature gradient has been obtained
explicitly to second order in density and the temperature gradient. Some
thermodynamical quantities are calculated from the velocity distribution
function for hard-core molecules and compared with those for Maxwell molecules
and the steady-state Bhatnagar-Gross-Krook(BGK) equation. We have found
qualitative differences between hard-core molecules and Maxwell molecules in
the thermodynamical quantities, and also confirmed that the steady-state BGK
equation belongs to the same universality class as Maxwell molecules.Comment: 36 pages, 4 figures, 5 table
Assessment of Gas-Surface Interaction Models for Computation of Rarefied Hypersonic Flow
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76727/1/AIAA-36375-113.pd
Is a persistent global bias necessary for the establishment of planar cell polarity?
Planar cell polarity (PCP)âthe coordinated polarisation of a whole field of cells within the plane of a tissueârelies on the interaction of three modules: a global module that couples individual cellular polarity to the tissue axis, a local module that aligns the axis of polarisation of neighbouring cells, and a readout module that directs the correct outgrowth of PCP-regulated structures such as hairs and bristles. While much is known about the molecular components that are required for PCP, the functional details ofâand interactions betweenâthe modules remain unclear. In this work, we perform a mathematical and computational analysis of two previously proposed computational models of the local module (Amonlirdviman et al., Science, 307, 2005; Le Garrec et al., Dev. Dyn., 235, 2006). Both models can reproduce wild-type and mutant phenotypes of PCP observed in the Drosophila wing under the assumption that a tissue-wide polarity cue from the global module persists throughout the development of PCP. We demonstrate that both models can also generate tissue-level PCP when provided with only a transient initial polarity cue. However, in these models such transient cues are not sufficient to ensure robustness of the resulting cellular polarisation
Modelling and analysis of planar cell polarity
Planar cell polarity (PCP) occurs in the epithelia of many animals and can lead to the alignment of hairs, bristles and feathers; physiologically, it can organise ciliary beating. Here we present two approaches to modelling this phenomenon. The aim is to discover the basic mechanisms that drive PCP, while keeping the models mathematically tractable. We present a feedback and diffusion model, in which adjacent cell sides of neighbouring cells are coupled by a negative feedback loop and diffusion acts within the cell. This approach can give rise to polarity, but also to period two patterns. Polarisation arises via an instability provided a sufficiently strong feedback and sufficiently weak diffusion. Moreover, we discuss a conservative model in which proteins within a cell are redistributed depending on the amount of proteins in the neighbouring cells, coupled with intracellular diffusion. In this case polarity can arise from weakly polarised initial conditions or via a wave provided the diffusion is weak enough. Both models can overcome small anomalies in the initial conditions. Furthermore, the range of the effects of groups of cells with different properties than the surrounding cells depends on the strength of the initial global cue and the intracellular diffusion
Discussion: âHeat Transfer and Forces for Free-Molecule Flow on a Concave Cylindrical Surfaceâ (Sparrow, E. M., Jonsson, V. K., Lundgren, T. S., and Chen, T. S., 1964, ASME J. Heat Transfer, 86, pp. 1â9)
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