Bus Frequency Optimization: When Waiting Time Matters in User Satisfaction

Reorganizing bus frequency to cater for the actual travel demand can save the cost of the public transport system significantly. Many, if not all, existing studies formulate this as a bus frequency optimization problem which tries to minimize passengers' average waiting time. However, many investigations have confirmed that the user satisfaction drops faster as the waiting time increases. Consequently, this paper studies the bus frequency optimization problem considering the user satisfaction. Specifically, for the first time to our best knowledge, we study how to schedule the buses such that the total number of passengers who could receive their bus services within the waiting time threshold is maximized. We prove that this problem is NP-hard, and present an index-based algorithm with $(1-1/e)$ approximation ratio. By exploiting the locality property of routes in a bus network, we propose a partition-based greedy method which achieves a $(1-\rho)(1-1/e)$ approximation ratio. Then we propose a progressive partition-based greedy method to further improve the efficiency while achieving a $(1-\rho)(1-1/e-\varepsilon)$ approximation ratio. Experiments on a real city-wide bus dataset in Singapore verify the efficiency, effectiveness, and scalability of our methods

First NH3 detection of the Orion Bar

Odin has successfully observed three regions in the Orion A cloud, i.e. Ori KL, Ori S and the Orion Bar, in the 572.5 GHz rotational ground state line of ammonia, ortho-NH3 (J,K) = (1,0) -> (0,0), and the result for the Orion Bar represents the first detection in an ammonia line. Several velocity components are present in the data. Specifically, the observed line profile from the Orion Bar can be decomposed into two components, which are in agreement with observations in high-J CO lines by Wilson et al. 2001. Using the source model for the Orion Bar by these authors, our Odin observation implies a total ammonia abundance of NH3/H2 = 5E-9.Comment: 4 pages with 2 figures, accepted for publication in A&

Dysregulation of Mitochondrial Dynamics and the Muscle Transcriptome in ICU Patients Suffering from Sepsis Induced Multiple Organ Failure

BACKGROUND: Septic patients treated in the intensive care unit (ICU) often develop multiple organ failure including persistent skeletal muscle dysfunction which results in the patient's protracted recovery process. We have demonstrated that muscle mitochondrial enzyme activities are impaired in septic ICU patients impairing cellular energy balance, which will interfere with muscle function and metabolism. Here we use detailed phenotyping and genomics to elucidate mechanisms leading to these impairments and the molecular consequences. METHODOLOGY/PRINCIPAL FINDINGS: Utilising biopsy material from seventeen patients and ten age-matched controls we demonstrate that neither mitochondrial in vivo protein synthesis nor expression of mitochondrial genes are compromised. Indeed, there was partial activation of the mitochondrial biogenesis pathway involving NRF2alpha/GABP and its target genes TFAM, TFB1M and TFB2M yet clearly this failed to maintain mitochondrial function. We therefore utilised transcript profiling and pathway analysis of ICU patient skeletal muscle to generate insight into the molecular defects driving loss of muscle function and metabolic homeostasis. Gene ontology analysis of Affymetrix analysis demonstrated substantial loss of muscle specific genes, a global oxidative stress response related to most probably cytokine signalling, altered insulin related signalling and a substantial overlap between patients and muscle wasting/inflammatory animal models. MicroRNA 21 processing appeared defective suggesting that post-transcriptional protein synthesis regulation is altered by disruption of tissue microRNA expression. Finally, we were able to demonstrate that the phenotype of skeletal muscle in ICU patients is not merely one of inactivity, it appears to be an actively remodelling tissue, influenced by several mediators, all of which may be open to manipulation with the aim to improve clinical outcome. CONCLUSIONS/SIGNIFICANCE: This first combined protein and transcriptome based analysis of human skeletal muscle obtained from septic patients demonstrated that losses of mitochondria and muscle mass are accompanied by sustained protein synthesis (anabolic process) while dysregulation of transcription programmes appears to fail to compensate for increased damage and proteolysis. Our analysis identified both validated and novel clinically tractable targets to manipulate these failing processes and pursuit of these could lead to new potential treatments

Unknown cadaver: its historical and academic importance for human anatomy

Observações feitas na maioria das universidades brasileiras estrangeiras, e, inclusive, em algumas sobre o aspecto acadêmico do uso de cadáveres humanos como principal material que suporta e direciona a Anatomia Humana nos cursos da área da saúde, traz, dentre outras conclusões de caráter didático, uma questão de formação, muito mais importante do que uma simples questão de, apenas, informação universitária. Há de se concordar que, mesmo com o fabuloso avanço tecnológico e suas possibilidades, nossas universidades hoje, primam mais pela questão informativa do que propriamente pela formativa, ao passo que ternos consciência de que o ser humano necessita igualmente de ambas. Em consequência disto, o principal objetivo deste trabalho é enfocar o valor acadêmico do cadáver, evidenciando sua importante relação histórica, sem a qual a Anatomia não existiria e, certamente, a Medicina também não teria ultrapassado suas fronteiras limitadas do passado. O fato de ser este um trabalho realizado em uma universidade brasileira é revestido de responsabilidade e determinação em tentar colocar a figura do cadáver humano no lugar, no qual ele realmente deva estar, não apenas como simples material e instrumento de ensino da anatomia, mas também como lição de vida através da morte, criando Ciência e Arte, valorizando sua importância no contexto artístico e religioso, fatores estes imprescindíveis para a formação sócio-cultural humana. Por outro lado, este estudo com abordagem de caráter acadêmico, tornou-se dificil quanto a bibliografia específica, tendo sido feita portanto, quase toda a sua pesquisa em tratados históricos e anatômicos e, apenas alguns poucos trabalhos sobre a importância do cadáver para a Anatomia. Neste trabalho, procuramos usar ilustrações e figuras como documentação de caráter informativo e estético. Assim sendo, para uma abordagem mais ampla, o cadáver foi discutido desde sua relação histórica e acadêmica, até os dias de hoje, onde ainda se enfrenta, quase, as mesmas dificuldades do passado, no que diz respeito as questões de doação de corpo e órgãos, que deixaram de ser apenas institucionalmente acadêmicas, para ser mais rigorosamente sociais, segundo as Leis vigentes.Observations about most of brazilian universities and, even some of foreign ones, concerning the academic aspects of the use of human cadavers or corpses as the principal human anatomy method of studying, which maintain the basic courses of Health Sciences Field, that is, the cadaver or corpse himself should be also seen as a noble and magnificent way of transmitting knowledge and human values. Indeed, these observations have been showing some didactic results concerning much more, a matter of individual information than individual formation itself. Nowadays, this happens because scholasticism, differently from the past, seems to emphasize quantitative rather than qualitative teaching philosophy. We must admit that, even living in a technological era and being able to take advantages of its possibilities, our universities today emphasize much more the information itself than individual formation of our professionals of tomorrow, while we know that the individual needs both, equally. Therefore, the main goal of this work is focusing the academic importance of the human cadaver or corpse as a practical studying material, which is related to the own history of the practical Anatomy and consequently Medicine and, if it were not because of that, Medicine itself would not have gone beyond its limited frontiers of the past. On the other hand, the inedited academic meaning of this work became too difficult to come abroad, because of its specific bibliographical lack among scientific publications and, that's why, most of its text was found in the old Health Sciences, books and texts in general. However, another particular characteristic of this work is the great number of pictures and illustrations, which enrich the present text and substitute the lack of similar works' bibliography, In this work, the corpse is seen, from his historical relation and academical aspects the to present circumstances, where the need for anatomical study faces the same difficulties of the past, when Vesalius opened the way to the study of Human Anatomy, but as we know many years passed before Anatomy could be taught to medical students by means of dissection, the only method by which physicians and surgeons can fully acquire this knowledge. The scarcity of anatomical material seemed to be over at the present time, when laws were just enacted, such as specified law for the use of the corpse, organs and structures donation, that unfortunately did not solve the old and permanent problem, such as the absence of corpses for anatomical dissections.BV UNIFESP: Teses e dissertaçõe

IMPACT ON THE ATMOSPHERE

Mars Orbiting Plasma Surveyor (MOPS) is a microsatellite mission focused on studies of the near-Mars environment and the planet- solar wind interaction. The recent findings by the ESA Mars Express mission further highlighted the complexity of the processes taking place at the planet resulting from the solar wind interaction that strongly affect the planet's atmosphere. However, despite many previous Martian missions carrying different types of space plasma experiments, a comprehensive investigation including simultaneous measurements of particles, fields, and waves has never been performed. We consider a spinning spacecraft of a wet mass of 76.1 kg with a 9.7 kg payload, which can “hitchhike ” on another platform until Mars orbit insertion, and then be released into a suitable orbit. The spacecraft design is based on the experience gained in very successful Swedish space plasma missions, Viking, Freja, Astrid-1, and Astrid-2. In the present mission design, the MOPS spacecraft is equipped with its own 1m high gain antenna for direct communication with the Earth. The payload includes a wave experiment with wire booms, magnetometer with a rigid boom, Langmuir probes, electron and ion energy spectrometers and an ion mass analyzer. An energetic neutral atom imager and an UV photometer may complete the core payload. One of the proposed scenarios is piggy- backing on the Russian Phobos- Grunt mission to be launched to Mars in 2011