The SPTPoL extended cluster survey

We describe the observations and resultant galaxy cluster catalog from the 2770 deg2 SPTpol Extended Cluster Survey (SPT-ECS). Clusters are identified via the Sunyaev-Zel'dovich (SZ) effect and confirmed with a combination of archival and targeted follow-up data, making particular use of data from the Dark Energy Survey (DES). With incomplete follow-up we have confirmed as clusters 244 of 266 candidates at a detection significance ξ ≥ 5 and an additional 204 systems at 4 4 threshold, and 10% of their measured SZ flux. We associate SZ-selected clusters, from both SPT-ECS and the SPT-SZ survey, with clusters from the DES redMaPPer sample, and we find an offset distribution between the SZ center and central galaxy in general agreement with previous work, though with a larger fraction of clusters with significant offsets. Adopting a fixed Planck-like cosmology, we measure the optical richness-SZ mass (l - M) relation and find it to be 28% shallower than that from a weak-lensing analysis of the DES data-a difference significant at the 4σ level-with the relations intersecting at λ = 60. The SPT-ECS cluster sample will be particularly useful for studying the evolution of massive clusters and, in combination with DES lensing observations and the SPT-SZ cluster sample, will be an important component of future cosmological analyses

Detection of CMB-cluster lensing using polarization data from SPTpol

We report the first detection of gravitational lensing due to galaxy clusters using only the polarization of the cosmic microwave background (CMB). The lensing signal is obtained using a new estimator that extracts the lensing dipole signature from stacked images formed by rotating the cluster-centered Stokes Q U map cutouts along the direction of the locally measured background CMB polarization gradient. Using data from the SPTpol 500     deg 2 survey at the locations of roughly 18 000 clusters with richness λ ≥ 10 from the Dark Energy Survey (DES) Year-3 full galaxy cluster catalog, we detect lensing at 4.8 σ . The mean stacked mass of the selected sample is found to be ( 1.43 ± 0.40 ) × 10 14 M ⊙ which is in good agreement with optical weak lensing based estimates using DES data and CMB-lensing based estimates using SPTpol temperature data. This measurement is a key first step for cluster cosmology with future low-noise CMB surveys, like CMB-S4, for which CMB polarization will be the primary channel for cluster lensing measurements

Structure-Based Design of a Potent and Selective Small Peptide Inhibitor of Mycobacterium tuberculosis 6-Hydroxymethyl-7, 8-Dihydropteroate Synthase: A Computer Modelling Approach

In an attempt to design novel anti-TB drugs, the target chosen is the enzyme 6-hydroxymethyl-7,8-dihydropteroate synthase (DHPS), which is an attractive target since it is present in microorganisms but not in humans. The existing drugs for this target are the sulfa drugs, which have been used for about seven decades. However, single mutations in the DHPS gene can cause resistance to sulfa drugs. Therefore, there is a need for the design of novel drugs. Based on the recently determined crystal structure of Mycobacterium tuberculosis (M.tb) DHPS complexed with a known substrate analogue, and on the crystal structures of E. coli DHPS and Staphylococcus aureus DHPS, we have identified a dipeptide inhibitor with the sequence WK. Docking calculations indicate that this peptide has a significantly higher potency than the sulfa drugs. In addition, the potency is 70-90 times higher for M.tb DHPS as compared to that for the pterin and folate-binding sites of key human proteins. Thus, the designed inhibitor is a promising lead compound for the development of novel antimycobcaterial agents

A Measurement of the Cosmic Microwave Background Lensing Potential and Power Spectrum from 500 deg2^2 of SPTpol Temperature and Polarization Data

International audienceWe present a measurement of the cosmic microwave background (CMB) lensing potential using 500 deg$^2$ of 150 GHz data from the SPTpol receiver on the South Pole Telescope. The lensing potential is reconstructed with signal-to-noise per mode greater than unity at lensing multipoles $L \lesssim 250$, using a quadratic estimator on a combination of CMB temperature and polarization maps. We report measurements of the lensing potential power spectrum in the multipole range of $100< L < 2000$ from sets of temperature-only, polarization-only, and minimum-variance estimators. We measure the lensing amplitude by taking the ratio of the measured spectrum to the expected spectrum from the best-fit $\Lambda$CDM model to the $\textit{Planck}$ 2015 TT+lowP+lensing dataset. For the minimum-variance estimator, we find $A_{\rm{MV}} = 0.944 \pm 0.058{\rm (Stat.)}\pm0.025{\rm (Sys.)}$; restricting to only polarization data, we find $A_{\rm{POL}} = 0.906 \pm 0.090 {\rm (Stat.)} \pm 0.040 {\rm (Sys.)}$. Considering statistical uncertainties alone, this is the most precise polarization-only lensing amplitude constraint to date (10.1 $\sigma$), and is more precise than our temperature-only constraint. We perform null tests and consistency checks and find no evidence for significant contamination

Constraints on Cosmological Parameters from the 500 deg2^2 SPTpol Lensing Power Spectrum

International audienceWe present cosmological constraints based on the cosmic microwave background (CMB) lensing potential power spectrum measurement from the recent 500 deg$^2$ SPTpol survey, the most precise CMB lensing measurement from the ground to date. We fit a flat $\Lambda$CDM model to the reconstructed lensing power spectrum alone and in addition with other data sets: baryon acoustic oscillations (BAO) as well as primary CMB spectra from Planck and SPTpol. The cosmological constraints based on SPTpol and Planck lensing band powers are in good agreement when analysed alone and in combination with Planck full-sky primary CMB data. With weak priors on the baryon density and other parameters, the CMB lensing data alone provide a 4\% constraint on $\sigma_8\Omega_m^{0.25} = 0.0593 \pm 0.025$.. Jointly fitting with BAO data, we find $\sigma_8=0.779 \pm 0.023$, $\Omega_m = 0.368^{+0.032}_{-0.037}$, and $H_0 = 72.0^{+2.1}_{-2.5}\,\text{km}\,\text{s}^{-1}\,\text{Mpc}^{-1}$, up to $2\,\sigma$ away from the central values preferred by Planck lensing + BAO. However, we recover good agreement between SPTpol and Planck when restricting the analysis to similar scales. We also consider single-parameter extensions to the flat $\Lambda$CDM model. The SPTpol lensing spectrum constrains the spatial curvature to be $\Omega_K = -0.0007 \pm 0.0025$ and the sum of the neutrino masses to be $\sum m_{\nu} < 0.23$ eV at 95\% C.L. (with Planck primary CMB and BAO data), in good agreement with the Planck lensing results. With the differences in the $S/N$ of the lensing modes and the angular scales covered in the lensing spectra, this analysis represents an important independent check on the full-sky Planck lensing measurement

Constraints on Cosmological Parameters from the 500 deg2^2 SPTpol Lensing Power Spectrum

International audienceWe present cosmological constraints based on the cosmic microwave background (CMB) lensing potential power spectrum measurement from the recent 500 deg$^2$ SPTpol survey, the most precise CMB lensing measurement from the ground to date. We fit a flat $\Lambda$CDM model to the reconstructed lensing power spectrum alone and in addition with other data sets: baryon acoustic oscillations (BAO) as well as primary CMB spectra from Planck and SPTpol. The cosmological constraints based on SPTpol and Planck lensing band powers are in good agreement when analysed alone and in combination with Planck full-sky primary CMB data. With weak priors on the baryon density and other parameters, the CMB lensing data alone provide a 4\% constraint on $\sigma_8\Omega_m^{0.25} = 0.0593 \pm 0.025$.. Jointly fitting with BAO data, we find $\sigma_8=0.779 \pm 0.023$, $\Omega_m = 0.368^{+0.032}_{-0.037}$, and $H_0 = 72.0^{+2.1}_{-2.5}\,\text{km}\,\text{s}^{-1}\,\text{Mpc}^{-1}$, up to $2\,\sigma$ away from the central values preferred by Planck lensing + BAO. However, we recover good agreement between SPTpol and Planck when restricting the analysis to similar scales. We also consider single-parameter extensions to the flat $\Lambda$CDM model. The SPTpol lensing spectrum constrains the spatial curvature to be $\Omega_K = -0.0007 \pm 0.0025$ and the sum of the neutrino masses to be $\sum m_{\nu} < 0.23$ eV at 95\% C.L. (with Planck primary CMB and BAO data), in good agreement with the Planck lensing results. With the differences in the $S/N$ of the lensing modes and the angular scales covered in the lensing spectra, this analysis represents an important independent check on the full-sky Planck lensing measurement

Broadband anti-reflective coatings for cosmic microwave background experiments

The desire for higher sensitivity has driven ground-based cosmic microwave background (CMB) experiments to employ ever larger focal planes, which in turn require larger reimaging optics. Practical limits to the maximum size of these optics motivates the development of quasi-optically-coupled (lenslet-coupled), multi-chroic detectors. These detectors can be sensitive across a broader bandwidth compared to waveguide-coupled detectors. However, the increase in bandwidth comes at a cost: the lenses (up to 700 mm diameter) and lenslets ( 5 mm diameter, hemispherical lenses on the focal plane) used in these systems are made from high-refractive-index materials (such as silicon or amorphous aluminum oxide) that reflect nearly a third of the incident radiation. In order to maximize the faint CMB signal that reaches the detectors, the lenses and lenslets must be coated with an anti-reflective (AR) material. The AR coating must maximize radiation transmission in scientifically interesting bands and be cryogenically stable. Such a coating was developed for the third generation camera, SPT-3G, of the South Pole Telescope (SPT) experiment, but the materials and techniques used in the development are general to AR coatings for mm-wave optics. The three-layer polytetra uoroethylene-based AR coating is broadband, inexpensive, and can be manufactured with simple tools. The coating is field tested; AR coated focal plane elements were deployed in the 2016-2017 austral summer and AR coated reimaging optics were deployed in 2017-2018