Effect Of G2706A and G1051A polymorphisms of the ABCA1 gene on the lipid, oxidative stress and homocystein levels in Turkish patients with polycystıc ovary syndrome

<p>Abstract</p> <p>Background</p> <p>Obesity, insulin resistance and hyperandrogenism, crucial parameters of Polycystic ovary syndrome (PCOS) play significant pathophysiological roles in lipidemic aberrations associated within the syndrome. Parts of the metabolic syndrome (low HDL and insulin resistance) appeared to facilitate the association between PCOS and coronary artery disease, independently of obesity. ABCA1 gene polymorphism may be altered this components in PCOS patients.</p> <p>In this study, we studied 98 PCOS patients and 93 healthy controls. All subjects underwent venous blood drawing for complete hormonal assays, lipid profile, glucose, insulin, malondialdehyde, nitric oxide, disulfide levels and ABCA genetic study.</p> <p>Results</p> <p>In PCOS group fasting glucose, DHEAS, 17-OHP, free testosterone, total-cholesterol, triglyceride, LDL-cholesterol and fibrinogen were significantly different compare to controls. The genotype ABCA G2706A distribution differed between the control group (GG 60.7%, GA 32.1%, AA 7.1%) and the PCOS patients (GG 8.7%, GA 8.7%, AA 76.8%). The frequency of the A allele (ABCAG2706A) was higher in PCOS patients than control group with 13,0% and 23,2%, respectively. In this study, the homocystein and insulin levels were significantly higher in PCOS patients with ABCA G1051A mutant genotype than those with heterozygote and wild genotypes.</p> <p>Conclusions</p> <p>We found higher percentage of AA genotype and A allele of ABCA G2706A in PCOS patients compare to controls. The fasting insulin and homocystein levels were significantly higher in PCOS patients with ABCA G1051A mutant genotype than those with heterozygote and wild genotypes.</p

Allozyme variation in rattus rattus (rodentia: muridae) in turkey, with particular emphasis on the taxonomy

The Turkish black rat “Rattus rattus” shows variation in coat colour corresponding to the occurrence of three subspecies with intermediate colour stages: Rattus rattus rattus, Rattus r. alexandrinus and Rattus r. frugivorus. Turkish black rat populations were divided geographically into six sub-populations: Rr1= Northwest Anatolia, Rr2= Central Anatolia, Rr3= Eastern Mediterranean, Rr4= Western Mediterranean, Rr5= Turkish Thrace, and Rr6= Black Sea region. Genetic variation was assessed using twenty two isoenzyme systems. Seven of twenty-two loci (Pgm-1, Hk, Me-M, G3pdh, Gpdh-1, Gpi, Fum-1) were found to be polymorphic. The mean value of FST is found to be 0.073, indicating 7.3 % genetic variation among groups and suggesting the existence of a moderate differentiation between sub-populations of the Turkish black rat. Overall mean heterozygosity (Ho= direct count) for sub-populations was Ho= 0.020, ranging from 0.008 to 0.031. Nei’s measure of genetic distance showed that Rr2 and Rr6 were the most identical and sub-populations Rr1 and Rr5 had diverged the most. © 2008 Taylor &amp; Francis Group, LLC

Is Gastric Xanthelasma an Alarming Endoscopic Marker for Advanced Atrophic Gastritis and Intestinal Metaplasia?

PMID = 2725098

Bleomycin-induced in vitro 3D spheroid model to emulate pulmonary fibrosis

[No Abstract Available]Ege University Scientific Research Fund (Grant number: FGA-2020-21686) and Presidency of the Republic of Turkey, Presidency of Strategy and Budget (Grant number: 2019K12-149080) are appreciated for their supports.Ege University Scientific Research Fund [FGA-2020-21686]; Presidency of the Republic of Turkey, Presidency of Strategy and Budget [2019K12-149080

Identifying Clinical Characteristics of Hypoparathyroidism in Turkey: HIPOPARATURK-NET Study

Hypoparathyroidism is an orphan disease with ill-defined epidemiology that is subject to geographic variability. We conducted this study to assess the demographics, etiologic distribution, treatment patterns and complication frequency of patients with chronic hypoparathyroidism in Turkey. This is a retrospective, cross-sectional database study, with collaboration of 30 endocrinology centers located in 20 cities across seven geographical regions of Turkey. A total of 830 adults (mean age 49.6 ± 13.5 years; female 81.2%) with hypoparathyroidism (mean duration 9.7 ± 9.0 years) were included in the final analysis. Hypoparathyroidism was predominantly surgery-induced (n = 686, 82.6%). The insulting surgeries was carried out mostly due to benign causes in postsurgical group (SG) (n = 504, 73.5%) while patients in nonsurgical group (NSG) was most frequently classified as idiopathic (n = 103, 71.5%). The treatment was highly dependent on calcium salts (n = 771, 92.9%), calcitriol (n = 786, 94.7%) and to a lower extent cholecalciferol use (n = 635, 76.5%) while the rate of parathyroid hormone (n = 2, 0.2%) use was low. Serum calcium levels were most frequently kept in the normal range (sCa 8.5–10.5 mg/dL, n = 383, 46.1%) which might be higher than desired for this patient group. NSG had a lower mean plasma PTH concentration (6.42 ± 5.53 vs. 9.09 ± 7.08 ng/l, p < 0.0001), higher daily intake of elementary calcium (2038 ± 1214 vs. 1846 ± 1355 mg/day, p = 0.0193) and calcitriol (0.78 ± 0.39 vs. 0.69 ± 0.38 mcg/day, p = 0.0057), a higher rate of chronic renal disease (9.7% vs. 3.6%, p = 0.0017), epilepsy (6.3% vs. 1.6%, p = 0.0009), intracranial calcifications (11.8% vs. 7.3%, p < 0.0001) and cataracts (22.2% vs. 13.7%, p = 0.0096) compared to SG. In conclusion, postsurgical hypoparathyroidism is the dominant etiology of hypoparathyroidism in Turkey while the nonsurgical patients have a higher disease burden with greater need for medications and increased risk of complications than the postsurgical patients. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature

PEM Yakıt pilleri için kompozit membranlar ve elektrokatalizörlerin geliştirilmesi ve uzun dönem performanslarının belirlenmesi

TÜBİTAK MAG01.11.2012Proton değişim membranlı (PEM) yakıt pilleri, hidrojen enerji sisteminin en önemli cihazlarından biridir. Her geçen gün ticari uygulaması yaygınlaşmaktadır. Bu yeni teknolojinin gelişiminde yer almamız önemlidir. Bu projenin amacı PEM yakıt pillerinin en önemli elemanı olan membran elektrot bileşimini oluşturan proton iletim özelliğine sahip zarların iyileştirilmesi, etkin karbon destek yapıların ve elektrokatalizörlerin hazırlanması, elektrot üretim teknolojisinin geliştirilmesi ve bu malzemelerin uzun dönem dayanıklılık testlerinin gerçekleştirilmesidir. PEM yakıt pilinde en çok kullanılan proton iletken zar, Nafion‟a, nano boyutta TiO2 ve SiO2 katkı malzemeleri eklenmesiyle elde edilen nano kompozit membranla PEM yakıt pilinin çalışma sıcaklığı arttırılmıştır. Nano boyutta inorganik madde eklenmesiyle polimer ve inorganik partiküller arasında yüksek spefisik etkileşim yüzeyi sağlanmış ve yüksek sıcaklıklarda (80-110oC) membran yapısında bulunan kimyasal suyun dehidrasyonu önlenmiştir. Ayrıca membranın ısıl ve mekanik kararlılığı arttırılmıştır. Bu projede por yapısı silisyum bazlı bir kalıpla hazırlanan ve daha sonra bu yapının karbona dönüştürülmesiyle oluşturulan, içi boşluklu mezo gözenekli kabuk yapılı karbon destek malzemesi hazırlanmıştır. Bu malzemeye Pt nanoparçacıklar tutturularak özgün bir elektrokatalizör elde edilmiştir. Çevrimsel voltametri tekniğiyle elektrokatalizörlerin hidrojen oksidasyon ve oksijen redüksiyon reaksiyon aktiviteleri belirlenmiştir. Geliştirilen kompozit membranlar ve elektrokatalizörlerin uzun süre dayanıklılık testleri uluslararası kabul gören protokollere göre pil içinde ve pil dışında yapılan testlerle belirlenmiştir. Bu proje sonucunda ülkemizde PEM yakıt pilinin en önemli parçası olan membran–elektrot bileşenlerini en son teknolojiyle üretilebilir bilgi ve teknolojik birikim sağlanmıştır.Proton exchange membrane (PEM) fuel cell is one of the most important device for hydrogen energy system where hydrogen energy is providing a sustainable, clean and renewable energy use. Commercialization is spreading over day by day. We should be involved in this technological development. Membrane electrode assembly is the key part of PEM fuel cells; therefore the aim of this project is to improve its components such as to modify the proton exchange membrane, prepare new electrocatalyst, carbon support where as to develop a new electrode manufacturing method and to determine long term durability of these components. Operating temperature of PEM fuel cells are increased by the preperation of.nanocomposite polymeric membranes with the addition of nano-sized, TiO2, SiO2 into Nafion. Incorporation of nano sized inorganic materials in the membrane structure provided high specific interactions between the polymer and inorganic particles, and prevented loss of chemical water in the structure at high temperatures (80-110oC). Beside, thermal and mechanical stability of membrane have been improved. In this project, hollow core mesoporous carbon material was prepared by using silicon-based templates for pore formation and then converting it to carbon. Unique electrocatalyst were obtained by incorporating Pt nanoparticles on this material. Hydrogen oxidation and oxygen reduction activities of the electrocatalysts were determined by using cyclic voltammetry technique. Stability of newly developed materials for fuel cells have been determined by means of in- situ and ex-situ durability tests. Long term stability tests of the newly developed composite membranes and electrocatalysts have been performed according to internationally accepted protocols

Current Situation and Future Perspectives in Municipal Wastewater Treatment and Sludge Management in Turkey

Appropriate management of wastewater and sludge requires several systems. One of these systems is the collection of data about generation rates and characteristics of sludge. This paper aims to summarize the work done as a part of a threeyear project requested by the Turkish Ministry of Environment and Urbanization. Efforts involved preparation and evaluation of a detailed questionnaire for currently operated wastewater treatment plants (INWTPs) in Turkey, collection and confirmation of information from visits to large scale plants, calculation of theoretical sludge generation rates from data provided, and its comparison to reported sludge amounts