Methodology to Measure the Protective Areal Density of Ceramic Tiles Against Projectile Impact

The protective areal density of any armour material is the important property required for armour design. In this study, ballistic performance of hot pressed boron carbide tiles, with a tile thickness of 12.2 mm, was evaluated using the protective areal density (PAD) test method, against hard steel 12.7 mm armour piercing (AP) projectiles. The binary response data on complete penetration/ partial penetration obtained from PAD testing was fitted with the standard logistic regression model. A detailed discussion on statistical procedure has been presented. The PAD (pp = 0.5) was estimated to be 82.5 kg/m2 and the lower and upper bounds of 95 per cent confidence interval for (PAD) (pp = 0.5) was found to lie between 79.5 kg/m2 and 85.0 kg/m2

Ballistic Performance of Alumina and Zirconia-toughened Alumina Against 7.62 Armour Piercing Projectile

A study was carried out to compare the ballistic performance of high purity alumina and zirconia-toughened alumina (ZTA) using depth of penetration (DoP) test configuration against 7.62 mm armour piercing (AP) ammunition. The effect of tile thickness on the differential efficiency factor (DEF) was studied for tile thickness in the range of 3 mm to 6 mm for alumina tiles and 3 mm to 5 mm for ZTA tiles. The DEF is found to increase as tile thickness increases. An analysis on the failed shots showed that the residual shot weight does not follow a single linear relationship with ceramic tile thickness unlike the residual DoP for all thicknesses of tiles. Post-ballistic analysis on ceramic powder for particle size distribution was carried out and the results are presented.Defence Science Journal, Vol. 64, No. 5, September 2014, pp.477-483, DOI:http://dx.doi.org/10.14429/dsj.64.674

Leggere le Indicazioni. Riflessioni e proposte per la scuola dell'infanzia

Il volume presenta il testo delle indicazioni nazionali per il curricolo della scuola dell'infanzia e del primo ciclo d'istruzione, pubblicato in forma ufficiale dal Ministero dell'Istruzione nel 2013, e ne propone un commento per quanto riguarda la parte relativa alla scuola dell'infanzia, mettendo a fuoco alcune tematiche cruciali: l'idea di scuola, di relazione educativa, di contesto, di continuità, di attività professional

Evaluation of scale-adaptive simulation for transonic cavity flows

Scale-adaptive simulations of transonic cavities with and without doors are presented in this paper. Results were compared with detached-eddy simulations for cavities with length-to-depth ratios of 5 and 7. The Mach and Reynolds numbers (based on the cavity length) were 0.85 and 6.5 × 106, respectively, and the grid sizes were 5.0 million for the clean cavity with doors-off and 5.5 million for the clean cavity with doors-on. Instantaneous Mach number contours showed that the shear layer broke down for both the doors on and doors off cases and that the flows had a high level of unsteadiness inside them. The two L/D ratios of cavities were seen to have similar acoustic signatures reaching maximum sound levels of 170 dB. Spectral analyses for the cavities without doors revealed that by changing the length-to-depth ratio from five to seven, the dominant acoustic modes at the front and rear of the cavities were shifted from the second and third modes to the first and second modes respectively. Proper orthogonal decomposition was used to reduce the data storage using modes constructed from flowfield snapshots taken at regular intervals

Antimicrobial Peptides Human Beta-Defensin-2 and -3 Protect the Gut During Candida albicans Infections Enhancing the Intestinal Barrier Integrity: In Vitro Study

The intestinal mucosa is composed of a monolayer of epithelial cells, which is highly polarized and firmly united to each other thanks to the presence of proteins complexes, called Tight junctions (TJs). Alteration of the mucus layer and TJs causes an increase in intestinal permeability, which can lead to a microbial translocation and systemic disorders. Candida albicans, in addition to its role of commensal, is an opportunistic pathogen responsible for disseminated candidiasis, especially in immunocompromised subjects where the dysbiosis leads to damage of the intestinal mucosal barrier. In this work, we used a line of intestinal epithelial cells able to stably express the genes that encodes human beta defensin-2 (HBD-2) and -3 (HBD-3) to monitor the invasion of C. albicans in vitro. Defensins are a group of antimicrobial peptides (AMPs) found in different living organisms, and are involved in the first line of defense in the innate immune response against pathogens. The results obtained show that the presence of antimicrobial peptides improves the expression of TJs and increases the Trans Epithelial Electrical Resistence value. In addition, the invasive ability of C. albicans in transfected cells is significantly reduced, as well as the expression levels of genes involved in the apoptotic pathway. Through the study of interaction between antimicrobial peptides and microbiota we will be able in the future to better understand the mechanisms by which they exert the host defense function against intestinal pathogens

Antimicrobial peptide human β-defensin-2 improves in vitro cellular viability and reduces pro-inflammatory effects induced by enteroinvasive Escherichia coli in Caco-2 cells by inhibiting invasion and virulence factors’ expression

Escherichia coli is one of the commensal species most represented in the intestinal microbiota. However, there are some strains that can acquire new virulence factors that enable them to adapt to new intestinal niches. These include enteroinvasive E. coli (EIEC) that is responsible for the bacillary dysentery that causes severe diarrheal symptoms in both children and adults. Due to the increasing onset of antibiotic resistance phenomena, scientific research is focused on the study of other therapeutic approaches for the treatment of bacterial infections. A promising alternative could be represented by antimicrobial peptides (AMPs), that have received widespread attention due to their broad antimicrobial spectrum and low incidence of bacterial resistance. AMPs modulate the immune defenses of the host and regulate the composition of microbiota and the renewal of the intestinal epithelium. With the aim to investigate an alternative therapeutic approach, especially in the case of antibiotic resistance, in this work we created a line of intestinal epithelial cells able to express high concentrations of AMP human β-defensin-2 (HBD-2) in order to test its ability to interfere with the pathogenicity mechanisms of EIEC. The results showed that HBD-2 is able to significantly reduce the expression of the proinflammatory cytokines by intestinal epithelial cells, the invasiveness ability of EIEC and the expression of invasion-associated genes

Nanoscale magnetic field mapping with a single spin scanning probe magnetometer

We demonstrate quantitative magnetic field mapping with nanoscale resolution, by applying a lock-in technique on the electron spin resonance frequency of a single nitrogen-vacancy defect placed at the apex of an atomic force microscope tip. In addition, we report an all-optical magnetic imaging technique which is sensitive to large off-axis magnetic fields, thus extending the operation range of diamond-based magnetometry. Both techniques are illustrated by using a magnetic hard disk as a test sample. Owing to the non-perturbing and quantitative nature of the magnetic probe, this work should open up numerous perspectives in nanomagnetism and spintronics

Robust optical frequency dissemination with a dual-polarization coherent receiver

Frequency dissemination over optical fiber links relies on measuring the phase of fiber-delivered lasers. Phase is extracted from optical beatnotes and the detection fails in case of beatnotes fading due to polarization changes, which strongly limit the reliability and robustness of the dissemination chain. We propose a new method that overcomes this issue, based on a dual-polarization coherent receiver and a dedicated signal processing that we developed on a field programmable gated array. Our method allowed analysis of polarization-induced phase noise from a theoretical and experimental point of view and endless tracking of the optical phase. This removes a major obstacle in the use of optical links for those physics experiments where long measurement times and high reliability are required

Circulating miR-22, miR-24 and miR-34a as Novel Predictive Biomarkers to Pemetrexed-Based Chemotherapy in Advanced Non-Small Cell Lung Cancer

Pemetrexed has been widely used in patients with advanced non-small cell lung cancer (NSCLC). The clinical relevance of polymorphisms of folate pathway genes for pemetrexed metabolism have not been fully elucidated yet. The aim of this study was to evaluate the expression levels of circulating miR-22, miR-24, and miR-34a, possibly involved in folate pathway, in NSCLC patients treated with pemetrexed compared with healthy controls and to investigate their impact on patient clinical outcomes. A total of 22 consecutive patients with advanced NSCLC, treated with pemetrexed-based chemotherapy and 27 age and sex matched healthy controls were included in this preliminary analysis. miR-22, miR-24, and miR-34a targets were identified by TargetScan 6.2 algorithm, validating the involvement of these microRNAs in folate pathway. MicroRNAs were isolated from whole blood and extracted with miRNAeasy Mini Kit (Qiagen). miRNA profiling was performed using Real-Time PCR. SPSS 17 was used to data analysis. miR-22, miR-24, and miR-34a were found upregulated (P<0.05) in NSCLC patients versus healthy controls. Higher expression levels were recorded for miR-34a. Nevertheless, significantly higher miR-22 expression was observed in patients developing progressive disease (P=0.03). No significant associations with clinical outcome were recorded for miR-24 and miR-34a. Albeit preliminary, these data support the involvement of miR-22, miR-24, and miR-34a in advanced NSCLC. The correlation between high expression of miR-22 in whole blood and the lack of response in pemetrexed treated NSCLC patients indicates that miR-22 could represent a novel predictive biomarker for pemetrexed-based treatment

Generalized Cost-Effectiveness of Residential Wind Mitigation Strategies for Wood-Frame, Single Family House in the USA

Wind is one of the deadliest and most expensive hazards in the United States. Wind hazards cause significant damage to buildings and economic losses to homeowners. Economic losses average approximately $3.8 billion annually from hurricane winds and are not decreasing, even despite enhanced construction practices to reduce wind damage. Thus, the effectiveness of mitigation strategies should be evaluated in order to lower the cost incurred by this hazard. Several studies have suggested building code improvements to mitigate the wind hazard, this additional comprehensive research provides selecting economically beneficial mitigation strategies to consider in building code revisions. In a step toward addressing this need, the current study was conducted to determine the cost effectiveness of mitigation strategies for new and retrofit construction of a wood-framed, single-family, residential building case study. Net benefit, defined as the difference between the life-cycle wind loss before and after implementation of the mitigation strategy, was calculated for 15 wind mitigation strategies and their combinations, with new and retrofit construction costs ranging between$1,200 to $12,000 and a decision-making time horizon ranging between 5 and 30 years. Payback periods, defined as the number of years to recover the investment, were calculated for each mitigation strategy. Results were summarized by cost effectiveness for all ASCE 7 wind speed contour intervals. The results of this study serve as a starting point for further refinement of the economic justification needed to properly evaluate potential building code changes