Supply Chain Management in Competitive Structure of Sochi Health Resort and Spa Industry: Strategic Groups Analysis

Abstract- In the health industry, distribution model, customers, and product catalog pose a unique set of problems for your supply chain. The article discusses the identification of strategic groups within health and resort services market based on the suuply chain strategiers. Segmentation of competitors included the following steps: establishing mobility barriers; classification of sanatoriums and health resorts taking into account the mobility barriers; identification of strategic groups; description of strategic groups existing in the market of health-resort and spa services. Five strategic groups were identified. Recommendations on the selection of competitive strategies were made for each group. The results of strategic grouping can be used in forming competitive advantages allowing to successfully compete with rival firms in spa market. The article presents the results of the research supported by grant ? 19-410-230059r_a from the Russian Foundation for Basic Research

Energy efficiency of world's leading copper producers

This paper provides an overview of the leading role that energy efficiency plays in the development of modern socio-economic systems, which serve as the foundation for building green economies. The main purpose of the paper is to develop a methodological toolkit for assessing energy efficiency of large industrial complexes and test it on the world's largest metallurgical complexes. The central object of the research is the Ural Mining and Metallurgical Company (UMMC), which mainly specializes in the production of copper and copper-based products. The study follows a comparative analysis of a set of preliminary selected energy efficiency indicators obtained from UMMC with those of the world's leading copper manufacturers and copper-based products. At the same time, in accordance with the methodical approach, it is proposed to divide the energy efficiency indicators of an industrial complex into three levels: the level of an industrial complex as a whole (1); the level of certain types of products manufactured in the industrial complex (2); the level of the technological process (3). To obtain summarized (synthetic) energy efficiency estimates of the industrial complex, the hierarchy analysis method has been proposed. For the comparative analysis of energy efficiency indicators of UMMC, the authors chose the following companies: Norilsk Nickel and Russian Copper Company and leading world companies, such as Glencore Xstrata Plc (Switzerland), Codelco (Chile), KGHM Polska Miedz SA (Poland), and Vedanta Resources (India). The obtained results revealed that UMMC strongly lags behind in a number of key energy efficiency indicators. During 2010-2016, a negative trend was observed in the majority of UMMC enterprises. The results also showed the practical applicability of the given methodical approach and the possibility of its wide use in solving energy efficiency problems of Russian industrial complexes for their strategic development. © 2020 WIT Press, www.witpress.co

Hybrid functional materials for tissue engineering : synthesis, in vivo drug release and SERS effect

The research presents the designing new hybrid biocompatible materials aimed to bone tissue engineering with enhanced osteoconductivity and functionality. The scaffolds consisted of electrospun polymeric matrix, modified with porous calcium carbonate (vaterite) coatings, were developed and studied. The subcutaneous implantation tests in vivo with white rats demonstrated the high degree of biocompatibility of vaterite-mineralized scaffolds. Moreover, the performed in vivo release of bioactive molecules, immobilized in mineral coating of scaffold, allowed to control the regeneration process in tissues in the implantation area. Also, the decoration of mineralized scaffold with silver nanoparticles exhibited the capability of exploiting these materials as effective substrates with providing surface enhanced Raman scattering (SERS) for precise detection of low concentrations of analyte. In this way, developed scaffolds can be promising materials with enhanced functionality of tissue regeneration, in vivo drug release and detection for designing novel smart devices for biomedicine

Пищевая и биологическая ценность мясных паштетов с использованием эмульсий из коллагенсодержащего сырья, прошедшего технологическую подготовку

Currently, animal proteins have a special role in the meat processing industry for meat products. A promising source of additional food protein production is natural collagen-containing raw materials, which can be used as part of protein-fat emulsions. The paper presents the results of research on nutritional and biological value of meat paste using new types of emulsions from collagen-containing raw materials, which have undergone technological treatment with bacteria p. Lactobacillus. To compare the data obtained, the studied samples of paste were compared with paste produces using emulsions from collagen-containing raw materials with no treatment, as well as subjected to hydrolysis. The results of determining indicators characterizing the nutritional and biological value of the developed paste are presented: content of protein, fat, nonessential and essential acids, polyunsaturated fatty acids and minerals. Development of a new method for preparing collagen-containing raw materials to be used in meat products will allow excluding vegetable protein from composition, as well as improving nutritional and biological value of the product. Collagen-containing raw materials used in meat paste will contribute to increase in use of biologically valuable secondary raw materials in meat-processing industry, as well as to expand of the range of high-quality food products of high nutritional and biological value for all age groups of population.В настоящее время в мясоперерабатывающей промышленности особую роль при изготовлении мясопродуктов занимают животные белки. Перспективным источником дополнительного получения пищевого белка является натуральное коллагенсодержащее сырье, которое может применяться в составе белково-жировых эмульсий. В статье исследована пищевая и биологическая ценность паштетов, изготовленных с использованием новых видов эмульсий из коллагенсодержащего сырья, подвергнутого технологической обработке бактериями р. Lactobacillus. Для сопоставления полученных данных исследуемые образцы паштетов сравнивали с паштетами, изготовленными с использованием эмульсий из коллагенсодержащего сырья без обработки, а также подвергнутого гидролизу. Представлены результаты определения показателей, характеризующих пищевую и биологическую ценность разработанных паштетов: содержание белка, жира, заменимых и незаменимых кислот, полиненасыщенных жирных кислот, минеральных веществ. Разработка нового способа подготовки коллагенсодержащего сырья с целью использования при изготовлении мясных продуктов позволит исключить из их состава растительный белок, а также улучшить пищевую и биологическую ценность продукта. Использование коллагенсодержащего сырья в составе мясных паштетов будет способствовать увеличению объемов использования биологически ценного вторичного сырья в мясоперерабатывающей промышленности, а также расширению ассортимента высококачественных продуктов питания повышенной пищевой и биологической ценности для всех возрастных групп населения

КЛИНИКО-ЛАБОРАТОРНЫЕ СОПОСТАВЛЕНИЯ ПРИ ПОСТМЕНОПАУЗАЛЬНОМ ОСТЕОПОРОЗЕ С НОРМАЛЬНОЙ И ПОВЫШЕННОЙ ФУНКЦИЕЙ ОКОЛОЩИТОВИДНЫХ ЖЕЛЕЗ

The need for a comprehensive diagnostic approach to the patients suffering osteoporosis is determined by high medical and social significance and disabling nature of complications. The objective of this research is to estimate features of calcium and bone metabolism depending on functional status of parathyroid glands. The study involved 150 post-menopausal women with a low bone mineral density. All patients underwent clinical and laboratory examination including a functional test for evaluating the enteral absorption of calcium. More expressed disorders of calcium and bone metabolism have been identified in patients with the development of secondary hyperparathyroidism in conjunction with the violation of enteral calcium absorption.Необходимость комплексного диагностического подхода к больным с остеопорозом объясняется высокой медико- социальной значимостью и инвалидизирующим характером осложнений. Целью исследования явилось изучение метаболизма кальция и костной ткани в зависимости от функционального состояния околощитовидных желез. Обследованы 150 женщин с остеопорозом, находящихся в постменопаузе. Выполнено полное клинико-лабораторное обследование, в том числе проведен функциональный тест с энтеральной нагрузкой кальцием, позволяющий косвенно оценить абсорбцию кальция в кишечнике. Показано более глубокое нарушение фосфорно-кальциевого обмена и более выраженное снижение минеральной плотности костной ткани у женщин в условиях развития вторичног

Functional (non-ulcerative) dyspepsia

The purpose of the study is to conduct a survey among students, to study the leading symptoms, as well as to identify risk factors in its development.Цель исследования – изучить ведущие симптомы и факторы риска развития ФД

Proceedings of the 24th Paediatric Rheumatology European Society Congress: Part three

From Springer Nature via Jisc Publications Router.Publication status: PublishedHistory: collection 2017-09, epub 2017-09-0

Information Technologies of Optimizing Designs and Manufacturing Techniques of Rubber-metal Products

It is shown that a high percentage of defective rubber-metal articles at the manufacturing process output is caused by neglecting the subsystem parameters connectivity at the design stage separately within the design and technology, as well as between these subsystems.The research is aimed at increasing the rubber-metal articles production stability and improving the rubber products quality through the development and introduction of a new integrated approach to the design and technology parameters optimization.In the general system of the integrated design of rubber-metal shock-absorbers, the subsystems of designs and manufacturing technologies are singled out, and the correlations between the parameters within these subsystems and the parameters of different subsystems are identified.Optimization problems have different objective functions, in which arguments often coincide fully or within certain boundaries. This significantly complicates calculations since the optimization problem in this case is often multiobjective and multiextremal. To solve this problem, the method that involves complex evolutionary optimization by means of a genetic algorithm is applied.For this, new attributes of the genetic algorithm are created. In particular, new star-shaped character models (chromosomes), with internal links between individual parents and flexible constraints on the variation of the latter during optimization are developed. The result is a paradoxical conclusion: there is an additional possibility to perform multi-criteria optimization of the design and manufacturing technology of rubber-metal articles deeper than with Pareto optimization because Pareto optimization involves a single value for all iterations of search of objective functions in the evolutionary optimization, and the arguments on each iteration may differ on some, connection depth-dependant value when using the proposed method

Mesenchymal stem cells lose the senescent phenotype under 3D cultivation

Abstract Background Three-dimensional (3D) cell culture is widely used in various fields of cell biology. In comparison to conventional two-dimensional (2D) cell culture, 3D cell culture facilitates a more accurate replication of the in vivo microenvironment, which is essential for obtaining more relevant results. The application of 3D cell culture techniques in regenerative medicine, particularly in mesenchymal stem cell (MSC)-based research, has been extensively studied. Many of these studies focus on the enhanced paracrine activity of MSCs cultured in 3D environments. However, few focus on the cellular processes that occur during 3D cultivation. Methods In this work, we studied the changes occurring within 3D-cultured MSCs (3D-MSCs). Specifically, we examined the expression of numerous senescent-associated markers, the actin cytoskeleton structure, the architecture of the Golgi apparatus and the localization of mTOR, one of the main positive regulators of replicative senescence. In addition, we assessed whether the selective elimination of senescent cells occurs upon 3D culturing by using cell sorting based on autofluorescence. Results Our findings indicate that 3D-MSCs were able to lose replicative senescence markers under 3D cell culture conditions. We observed changes in actin cytoskeleton structure, Golgi apparatus architecture and revealed that 3D cultivation leads to the nuclear localization of mTOR, resulting in a decrease in its active cytoplasmic form. Additionally, our findings provide evidence that 3D cell culture promotes the phenotypic reversion of senescent cell phenotype rather than their removal from the bulk population. Conclusion These novel insights into the biology of 3D-MSCs can be applied to research in regenerative medicine to overcome replicative senescence and MSC heterogeneity as they often pose significant concerns regarding safety and effectiveness for therapeutic purposes