3,226 research outputs found
Applications of CFD and visualization techniques
In this paper, three applications are presented to illustrate current techniques for flow calculation and visualization. The first two applications use a commercial computational fluid dynamics (CFD) code, FLUENT, performed on a Cray Y-MP. The results are animated with the aid of data visualization software, apE. The third application simulates a particulate deposition pattern using techniques inspired by developments in nonlinear dynamical systems. These computations were performed on personal computers
Metabolism of a tropical rainforest stream
Gradients in photosynthesis (P) and respiration (R) were measured on an unperturbed portion of the Rio Mameyes, a tropical stream in the Luquillo Experimental Forest, northeastern Puerto Rico. Rates of P, which were similar to those of streams in temperate-deciduous forests, were low in the heavily canopied headwaters (\u3c70 g O2 m−2 y−1) and were higher (453–634 g O2 m−2 y−1) in middle and lower reaches. Periphyton biomass did not show the expected increase as the canopy opened downstream, probably because of increasing herbivory in downstream reaches. Rates of R, which were much higher than in most temperate streams, also were lower in the headwaters (767 g O2 m−2 y−1) than in the middle and lower reaches (1550–1660 g O2 m−2 y−1). High rates of R and suppressed periphyton abundance caused annual P/R to be \u3c\u3c1 from headwaters to lower reaches. Results for the Rio Mameyes suggest that intense herbivory, which is favored by the presence of large herbivores and consistently high temperatures, may be more typical of tropical than temperate streams. Results also show that the tropical rainforest provides the stream with sufficient amounts of labile organic C to support high rates of respiration over long distances across the basin
Redshifts and Velocity Dispersions of Galaxy Clusters in the Horologium-Reticulum Supercluster
We present 118 new optical redshifts for galaxies in 12 clusters in the
Horologium-Reticulum supercluster (HRS) of galaxies. For 76 galaxies, the data
were obtained with the Dual Beam Spectrograph on the 2.3m telescope of the
Australian National University at Siding Spring Observatory. After combining 42
previously unpublished redshifts with our new sample, we determine mean
redshifts and velocity dispersions for 13 clusters, in which previous
observational data were sparse. In six of the 13 clusters, the newly determined
mean redshifts differ by more than 750 km/s from the published values. In the
case of three clusters, A3047, A3109, and A3120, the redshift data indicate the
presence of multiple components along the line of sight. The new cluster
redshifts, when combined with other reliable mean redshifts for clusters in the
HRS, are found to be distinctly bi-modal. Furthermore, the two redshift
components are consistent with the bi-modal redshift distribution found for the
inter-cluster galaxies in the HRS by Fleenor et al. (2005).Comment: 13 pages, 3 figures, Accepted to A
Bostonia: The Boston University Alumni Magazine. Volume 32
Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs
Convicts and coolies : rethinking indentured labour in the nineteenth century
This article seeks to shift the frame of analysis within which discussions of Indian indentured migration take place. It argues that colonial discourses and practices of indenture are best understood not with regard to the common historiographical framework of whether it was 'a new system of slavery', but in the context of colonial innovations in incarceration and confinement. The article shows how Indian experiences of and knowledge about transportation overseas to penal settlements informed in important ways both their own understandings and representations of migration and the colonial practices associated with the recruitment of indentured labour. In detailing the connections between two supposedly different labour regimes, it thus brings a further layer of complexity to debates around their supposed distinctions
Quantum Physics and Human Language
Human languages employ constructions that tacitly assume specific properties
of the limited range of phenomena they evolved to describe. These assumed
properties are true features of that limited context, but may not be general or
precise properties of all the physical situations allowed by fundamental
physics. In brief, human languages contain `excess baggage' that must be
qualified, discarded, or otherwise reformed to give a clear account in the
context of fundamental physics of even the everyday phenomena that the
languages evolved to describe. The surest route to clarity is to express the
constructions of human languages in the language of fundamental physical
theory, not the other way around. These ideas are illustrated by an analysis of
the verb `to happen' and the word `reality' in special relativity and the
modern quantum mechanics of closed systems.Comment: Contribution to the festschrift for G.C. Ghirardi on his 70th
Birthday, minor correction
The dark energy spectrometer - A potential multi-fiber instrument for the Blanco 4-meter telescope
We describe the preliminary design of the Dark Energy Spectrometer (DESpec), a fiber-fed spectroscopic instrument concept for the Blanco 4-meter telescope at Cerro Tololo Inter-American Observatory (CTIO). DESpec would take advantage of the infrastructure recently deployed for the Dark Energy Camera (DECam). DESpec would be mounted in the new DECam prime focus cage, would be interchangeable with DECam, would share the DECam optical corrector, and would feature a focal plane with ∼4000 robotically positioned optical fibers feeding multiple high-throughput spectrometers. The instrument would have a field of view of 3.8 square degrees, a wavelength range of approximately 500<λ<1000 nm, and a spectral resolution of R∼3000. DESpec would provide a powerful spectroscopic follow-up system for sources in the Southern hemisphere discovered by the Dark Energy Survey and LSST
Validation of a Dynamic Measure of Current Cognitive Reserve in a Longitudinally Assessed Sample of Healthy Older Adults.
Cognitive reserve (CR) is a theoretical construct describing the underlying cognitive capacity of an individual that confers differential levels of resistance to, and recovery from, brain injuries of various types. To date, estimates of an individual's level of CR have been based on single proxy measures that are retrospective and static in nature. To develop a measure of dynamic change in CR across a lifetime, we previously identified a latent factor, derived from an exploratory factor analysis of a large sample of healthy older adults, as current CR (cCR). In the present study, we examined the longitudinal results of a sample of 272 older adults enrolled in the Tasmanian Healthy Brain Project. Using results from 12-month and 24-month reassessments, we examined the longitudinal validity of the cCR factor using confirmatory factor analyses. The results of these analyses indicate that the cCR factor structure is longitudinally stable. These results, in conjunction with recent results from our group demonstrating dynamic increases in cCR over time in older adults undertaking further education, lend weight to this cCR measure being a valid estimate of dynamic change in CR over time
MicroRNA expression in multiple myeloma is associated with genetic subtype, isotype and survival
This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited - Copyright @ 2011 Chi et al.Background: MicroRNAs are small RNA species that regulate gene expression post-transcriptionally and are aberrantly expressed in many cancers including hematological malignancies. However, the role of microRNAs in the pathogenesis of multiple myeloma (MM) is only poorly understood. We therefore used microarray analysis to elucidate the complete miRNome (miRBase version 13.0) of purified tumor (CD138+) cells from 33 patients with MM, 5 patients with monoclonal gammopathy of undetermined significance (MGUS) and 9 controls.
Results: Unsupervised cluster analysis revealed that MM and MGUS samples have a distinct microRNA expression profile from control CD138+ cells. The majority of microRNAs aberrantly expressed in MM (109/129) were up-regulated. A comparison of these microRNAs with those aberrantly expressed in other B-cell and T-cell malignancies revealed a surprising degree of similarity (~40%) suggesting the existence of a common lymphoma microRNA signature. We identified 39 microRNAs associated with the pre-malignant condition MGUS. Twenty-three (59%) of these were also aberrantly expressed in MM suggesting common microRNA expression events in MM progression. MM is characterized by multiple chromosomal abnormalities of varying prognostic significance. We identified specific microRNA signatures associated with the most common IgH translocations (t(4;14) and t(11;14)) and del(13q). Expression levels of these microRNAs were distinct between the genetic subtypes (by cluster analysis) and correctly predicted these abnormalities in > 85% of cases using the support vector machine algorithm. Additionally, we identified microRNAs associated with light chain only myeloma, as well as IgG and IgA-type MM. Finally, we identified 32 microRNAs associated with event-free survival (EFS) in MM, ten of which were significant by univariate (logrank) survival analysis.
Conclusions: In summary, this work has identified aberrantly expressed microRNAs associated with the diagnosis, pathogenesis and prognosis of MM, data which will prove an invaluable resource for understanding the role of microRNAs in this devastating disease.This work was funded by grants from Leukaemia and Lymphoma Research (JC, EB, X-HC, DT, JB and JSW) and the Julian Starmer-Smith Memorial Fund (CHL). The authors acknowledge financial support from the
Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Oxford Radcliffe NHS Trust
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