Clinical characteristics of elderly depressive patients with low metaiodobenzylguanidine uptake

BACKGROUND: Recently, depression with Lewy body pathology before the appearance of parkinsonism and cognitive dysfunction has been drawing attention. Low cardiac metaiodobenzylguanidine (MIBG) uptake is helpful for early differentiation of Lewy body disease (LBD) from late-onset psychiatric disorders even before parkinsonism or dementia appears. In this study, we used MIBG uptake as a tool in suspected LBD, and evaluated the relationship of MIBG results to clinical characteristics and depressive symptoms. METHODS: Fifty-two elderly inpatients with depression were included in this study. The Hamilton Depression Rating Scale (HDRS) was administered at admission, and 123 I-MIBG cardiac scintigraphy was performed. Of 52 patients, 38 had normal and 14 had reduced MIBG uptake. RESULTS: Correlation analyses of the late phase heart-to-mediastinum (H/M) ratio on the MIBG test and each item of the HDRS revealed that the H/M ratio was significantly correlated with scores of 'agitation', 'anxiety-somatic', and 'retardation' on the HDRS. Mean HDRS composite scores of 'somatic and psychic anxiety (Marcos)' and 'somatic anxiety/somatization factor (Pancheri)' were higher in the low uptake group than in the normal uptake group. CONCLUSION: Elderly patients with depression who manifested an obvious somatic anxiety tend to show low MIBG uptake, and are more likely to have Lewy body pathology

Structural basis for the dual RNA-recognition modes of human Tra2-beta RRM

Human Transformer2-beta (hTra2-beta) is an important member of the serine/arginine-rich protein family, and contains one RNA recognition motif (RRM). It controls the alternative splicing of several pre-mRNAs, including those of the calcitonin/calcitonin gene-related peptide (CGRP), the survival motor neuron 1 (SMN1) protein and the tau protein. Accordingly, the RRM of hTra2-beta specifically binds to two types of RNA sequences [the CAA and (GAA)2 sequences]. We determined the solution structure of the hTra2-beta RRM (spanning residues Asn110–Thr201), which not only has a canonical RRM fold, but also an unusual alignment of the aromatic amino acids on the beta-sheet surface. We then solved the complex structure of the hTra2-beta RRM with the (GAA)2 sequence, and found that the AGAA tetra-nucleotide was specifically recognized through hydrogen-bond formation with several amino acids on the N- and C-terminal extensions, as well as stacking interactions mediated by the unusually aligned aromatic rings on the beta-sheet surface. Further NMR experiments revealed that the hTra2-beta RRM recognizes the CAA sequence when it is integrated in the stem-loop structure. This study indicates that the hTra2-beta RRM recognizes two types of RNA sequences in different RNA binding modes

Expansion Velocity of Ejecta in Tycho's Supernova Remnant Measured by Doppler Broadened X-ray Line Emission

We show that the expansion of ejecta in Tycho's supernova remnant (SNR) is consistent with a spherically symmetric shell, based on Suzaku measurements of the Doppler broadened X-ray emission lines. All the strong K_alpha line emission show broader widths at the center than at the rim, while the centroid energies are constant across the remnant (except for Ca). This is the pattern expected for Doppler broadening due to expansion of the SNR ejecta in a spherical shell. To determine the expansion velocities of the ejecta, we applied a model for each emission line feature having two Gaussian components separately representing red- and blue-shifted gas, and inferred the Doppler velocity difference between these two components directly from the fitted centroid energy difference. Taking into account the effect of projecting a three-dimensional shell to the plane of the detector, we derived average spherical expansion velocities independently for the K_alpha emission of Si, S, Ar, and Fe, and K_beta of Si. We found that the expansion velocities of Si, S, and Ar ejecta of 4700+/-100 km/s are distinctly higher than that obtained from Fe K_alpha emission, 4000+/-300 km/s, which is consistent with segregation of the Fe in the inner ejecta. Combining the observed ejecta velocities with the ejecta proper-motion measurements by Chandra, we derived a distance to the Tycho's SNR of 4+/-1 kpc.Comment: Accepted to Apj, 25 pages, 7 figures, 5 table

Long-Term Density Trend in the Mesosphere and Lower Thermosphere from Occultations of the Crab Nebula with X-Ray Astronomy Satellites

We present long-term density trends of the Earth's upper atmosphere at altitudes between 71 and 116 km, based on atmospheric occultations of the Crab Nebula observed with X-ray astronomy satellites, ASCA, RXTE, Suzaku, NuSTAR, and Hitomi. The combination of the five satellites provides a time period of 28 yr from 1994 to 2022. To suppress seasonal and latitudinal variations, we concentrate on the data taken in autumn (49< doy <111) and spring (235< doy <297) in the northern hemisphere with latitudes of 0--40 degrees. With this constraint, local times are automatically limited either around noon or midnight. We obtain four sets (two seasons times two local times) of density trends at each altitude layer. We take into account variations due to a linear trend and the 11-yr solar cycle using linear regression techniques. Because we do not see significant differences among the four trends, we combine them to provide a single vertical profile of trend slopes. We find a negative density trend of roughly -5 %/decade at every altitude. This is in reasonable agreement with inferences from settling rate of the upper atmosphere. In the 100--110 km altitude, we found an exceptionally high density decline of about -12 %/decade. This peak may be the first observational evidence for strong cooling due to water vapor and ozone near 110 km, which was first identified in a numerical simulation by Akmaev et al. (2006). Further observations and numerical simulations with suitable input parameters are needed to establish this feature.Comment: 38 pages, 9 figures, accepted for publication in Journal of Geophysical Research - Space Physic

Role of the node in controlling traffic of cadmium, zinc, and manganese in rice

Heavy metals are transported to rice grains via the phloem. In rice nodes, the diffuse vascular bundles (DVBs), which enclose the enlarged elliptical vascular bundles (EVBs), are connected to the panicle and have a morphological feature that facilitates xylem-to-phloem transfer. To find a mechanism for restricting cadmium (Cd) transport into grains, the distribution of Cd, zinc (Zn), manganese (Mn), and sulphur (S) around the vascular bundles in node I (the node beneath the panicle) of Oryza sativa ‘Koshihikari’ were compared 1 week after heading. Elemental maps of Cd, Zn, Mn, and S in the vascular bundles of node I were obtained by synchrotron micro-X-ray fluorescence spectrometry and electron probe microanalysis. In addition, Cd K-edge microfocused X-ray absorption near-edge structure analyses were used to identify the elements co-ordinated with Cd. Both Cd and S were mainly distributed in the xylem of the EVB and in the parenchyma cell bridge (PCB) surrounding the EVB. Zn accumulated in the PCB, and Mn accumulated around the protoxylem of the EVB. Cd was co-ordinated mainly with S in the xylem of the EVB, but with both S and O in the phloem of the EVB and in the PCB. The EVB in the node retarded horizontal transport of Cd toward the DVB. By contrast, Zn was first stored in the PCB and then efficiently transferred toward the DVB. Our results provide evidence that transport of Cd, Zn, and Mn is differentially controlled in rice nodes, where vascular bundles are functionally interconnected