ジシュ ガクシュウ ソクシン オ ウナガス ピアノ オンガク キョウイク ホウホウ ノ コウサツ : リズム アプリ リヨウ ジッタイ ト ピアノ レンシュウ ジカン ノ ジッタイ チョウサ ヨリ

学生の読譜能力の低さが幼児歌曲弾き歌いの学習上の障害となっているが、読譜力の向上については、従来より、①対面指導は効果が高いが十分な時間が取れない②対面指導の時間不足を補うための適切な自主学習教材がない、等の問題がある。この解決策として、自主学習教材「リズムアプリ」（スマホアプリ）の導入を考え、本年度は、その効果確認の予備調査として、リズムアプリを課題として学生に課し、その利用状況の調査を行った。その結果、学生が本アプリに取り組んでいることが確認できたので、次年度以降は本調査として効果確認を行いたい

Inclusion of gaming disorder criteria in ICD-11: A clinical perspective in favor

Data from a specialist treatment facility for Internet addiction (IA) in Japan showed that (a) the vast majority of treatment seekers are addicted to online games, (b) their symptoms are often quite severe, and (c) there is a significant demand for IA treatment. In addition, systemic obstacles to the delivery of medical services in Japan exist due to the exclusion of IA criteria from ICD-10. Consequently, the inclusion of GD criteria in ICD-11 will almost certainly increase the capacity and quality of treatment through advances in research and possible changes in national medical systems to meet treatment demand

ホイクシャ ヨウセイコウ ニオケル リョウイキ ｢ヒョウゲン｣ ノ ジュギョウ ニカンスル コウサツ : エンカク ジュギョウ ニオイテ ICT オ カツヨウシタ ガクセイ キョウドウ ゾウケイ トウ エンシュウ ジレイ

未曾有のコロナ禍により2020年度の学修環境はICT教育システムを利用した遠隔授業主体となった為、領域「表現」授業は、対面授業で行われているアクティブラーニング形式の演習形態を取り入れるべくICT機器を用いた双方向型遠隔授業形態を試みた。結果、オンライン上の強みを活かし、対面授業と同等、内容によっては対面授業より向いているものがあったので紹介する

A Case of Possible Concurrence of Dermatitis Herpetiformis and Linear Immunoglobulin A / Immunoglobulin G Bullous Dermatosis.

Linear immunoglobulin (Ig) A bullous dermatosis (LABD), one subtype of subepidermal autoimmune bullous skin diseases (AIBDs), is characterized by linear deposit of only IgA along the basement membrane zone (BMZ) on direct immunofluorescence (DIF) (1,2). Patients showing linear deposits of both IgA and IgG are diagnosed with linear IgA/IgG bullous dermatosis (LAGBD) (3,4). Dermatitis herpetiformis (DH) is another type of subepidermal AIBD characterized by clinically pruritic erythematous skin lesions with vesicles on the elbows, knees, and buttocks with granular IgA deposits of IgA by DIF (5). In this study, we report a Japanese case of a patient who showed possible concurrence of DH and LAGBD based on clinical, histological, and immunological findings

A Case of Possible Concurrence of Dermatitis Herpetiformis and Linear Immunoglobulin A / Immunoglobulin G Bullous Dermatosis.

Linear immunoglobulin (Ig) A bullous dermatosis (LABD), one subtype of subepidermal autoimmune bullous skin diseases (AIBDs), is characterized by linear deposit of only IgA along the basement membrane zone (BMZ) on direct immunofluorescence (DIF) (1,2). Patients showing linear deposits of both IgA and IgG are diagnosed with linear IgA/IgG bullous dermatosis (LAGBD) (3,4). Dermatitis herpetiformis (DH) is another type of subepidermal AIBD characterized by clinically pruritic erythematous skin lesions with vesicles on the elbows, knees, and buttocks with granular IgA deposits of IgA by DIF (5). In this study, we report a Japanese case of a patient who showed possible concurrence of DH and LAGBD based on clinical, histological, and immunological findings

Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia

<p>Abstract</p> <p>Background</p> <p>Schizophrenia is a complex genetic disorder caused by multiple genetic and environmental factors. The dystrobrevin-binding protein 1 (DTNBP1: dysbindin-1) gene is a major susceptibility gene for schizophrenia. Genetic variations in DTNBP1 are associated with cognitive functions, general cognitive ability and memory function, and clinical features of patients with schizophrenia including negative symptoms and cognitive decline. Since reduced expression of dysbindin-1 has been observed in postmortem brains of patients with schizophrenia, the sandy (sdy) mouse, which has a deletion in the Dtnbp1 gene and expresses no dysbindin-1 protein, could be an animal model of schizophrenia. To address this issue, we have carried out a comprehensive behavioral analysis of the sdy mouse in this study.</p> <p>Results</p> <p>In a rotarod test, sdy mice did not exhibit motor learning whilst the wild type mice did. In a Barnes circular maze test both sdy mice and wild type mice learned to selectively locate the escape hole during the course of the training period and in the probe trial conducted 24 hours after last training. However, sdy mice did not locate the correct hole in the retention probe tests 7 days after the last training trial, whereas wild type mice did, indicating impaired long-term memory retention. A T-maze forced alternation task, a task of working memory, revealed no effect of training in sdy mice despite the obvious effect of training in wild type mice, suggesting a working memory deficit.</p> <p>Conclusion</p> <p>Sdy mouse showed impaired long-term memory retention and working memory. Since genetic variation in DTNBP1 is associated with both schizophrenia and memory function, and memory function is compromised in patients with schizophrenia, the sdy mouse may represent a useful animal model to investigate the mechanisms of memory dysfunction in the disorder.</p

Cellular DBP and E4BP4 proteins are critical for determining the period length of the circadian oscillator

AbstractThe phenotypes of mice carrying clock gene mutations have been critical to understanding the mammalian clock function. However, behavior does not necessarily reflect cell-autonomous clock phenotypes, because of the hierarchical dominance of the central clock. We performed cell-based siRNA knockdown and cDNA overexpression and monitored rhythm using bioluminescent reporters of clock genes. We found that knockdown of DBP, D-box positive regulator, in our model led to a short-period phenotype, whereas overexpressing of DBP produced a long-period rhythm when compared to controls. Furthermore, knockdown and overexpressing of E4BP4, D-box negative regulator, led to an opposite effect of DBP. Our experiments demonstrated that D-box regulators play a crucial role in determining the period length of Per1 and Per2 promoter-driven circadian rhythms in Rat-1 fibroblasts

NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala

<p>Abstract</p> <p>Background</p> <p>Anxiety disorders are a highly prevalent and disabling class of psychiatric disorders. There is growing evidence implicating the glutamate system in the pathophysiology and treatment of anxiety disorders, though the molecular mechanism by which the glutamate system regulates anxiety-like behavior remains unclear.</p> <p>Results</p> <p>In this study, we provide evidence suggesting that tyrosine phosphorylation of the NMDA receptor, an ionotropic glutamate receptor, contributes to anxiety-like behavior. The GluN2B subunit of the NMDA receptor is tyrosine-phosphorylated: Tyr-1472 is the major phosphorylation site. Homozygous knock-in mice that express a Tyr-1472-Phe mutant of GluN2B, which prevents phosphorylation of this site, show enhanced anxiety-like behavior in the elevated plus-maze test. Expression of corticotropin-releasing factor (CRF), which is important for the regulation of anxiety-like behavior, is increased in the amygdala of the knock-in mice. Furthermore, injection of CRF receptor antagonist attenuated the enhanced anxiety-like behavior of the knock-in mice. We also show that elevated plus-maze exposure simultaneously induced de-phosphorylation of Tyr-1472 and increased CRF expression.</p> <p>Conclusions</p> <p>These data suggest that Tyr-1472 phosphorylation on GluN2B is important for anxiety-like behavior by negative regulation of CRF expression in the amygdala.</p

Influencia del aditivo eucon 1037 en la resistencia a la compresión de un concreto de f´c= 350 kg/cm2 - Cajamarca

El uso de los aditivos en nuestros días se ha convertido en una práctica muy utilizada para la obtención de concreto con mejores características y que estas se adecuen a las exigencias de la obra o estructura donde este material será utilizado. Uno de los tipos de aditivos más utilizados son los aditivos plastificantes, los cuales presentan una característica fundamental que es la reducción de agua utilizada en la mezcla de concreto, logrando obtener concretos con mayor trabajabilidad con bajas cantidades de agua, permitiendo que la resistencia a la compresión del concreto aumente. El aditivo EUCON 1037 es un aditivo reductor de agua de alto rango que puede ser adicionado al concreto en obra o en una planta de concreto, ese aditivo permite obtener concretos de alta resistencia por trabajar a baja relación agua/cemento, así mismo facilita la colocación permitiendo reducir la mano de obra y permite producir concretos fluidos con resistencias superiores a lo normal. En la presente tesis de investigación se tiene como objetivo principal el determinar la influencia que presenta el adicionar aditivo EUCON 1037 en un concreto de f’c = 350 Kg/cm2 con dosificaciones de 1.2%, 1.4% 1.7% de aditivo por peso de cemento; dosificaciones que se toman a partir de lo que indica la hoja técnica del aditivo cuyo uso es de (0.7% - 1.9% / Kg de cemento). Para ello se realizó la elaboración de especímenes de concreto a partir de una adecuada elaboración de diseños de mezcla, los mismos que fueron sometidos a ensayos a compresión uniaxial, siguiendo los procedimientos de las normas ASTM y NTP correspondientes. Estos diseños de mezcla se elaboraron con agregados de la cantera Acosta (Rio Chonta), que cumple con lo estipulado en las normas correspondientes y que cuyas características físicas serán determinadas en laboratorio, permitiendo la elaboración de los diseños de mezcla. Al finalizar con el trabajo de investigación se llegó a la conclusión que el aditivo EUCON 1037 aumenta considerablemente la resistencia a la compresión de concreto de f’c = 350 Kg/cm2, tal es así que para una dosificación de 1.7% de aditivo por peso de cemento, el aumento con respecto de la mezcla que no presenta ninguna adición es de 28.21% a edad de 7 días y 14.92% a edad de 28 días.Tesi