Toxic Shock Syndrome Toxin-1-producing Staphylococcus aureus Bacteremia and Exanthematous and Purpuric Disease with Leukocytoclastic Vasculitis in an Infant

Staphylococcus aureus exotoxin toxic shock syndrome toxin-1 (TSST-1) can cause a wide spectrum of immunopathological conditions, from toxic shock syndrome (TSS), a life-threatening illness, to neonatal TSS-like exanthematous disease (NTED), a self-limited mild disease. Leukocytoclastic vasculitis, which develops in the skin, is another immunopathological condition that is commonly observed in patients with IgA vasculitis during childhood. We report the case of an infant with an NTED-like exanthematous rash and IgA vasculitis-like purpuric skin lesions that were histopathologically diagnosed as leukocytoclastic vasculitis. A blood culture yielded methicillin-sensitive Staphylococcus aureus producing TSST-1, suggesting an etiological role in the aforementioned skin lesions

Toxic Shock Syndrome Toxin-1-producing Staphylococcus aureus Bacteremia and Exanthematous and Purpuric Disease with Leukocytoclastic Vasculitis in an Infant

Staphylococcus aureus exotoxin toxic shock syndrome toxin-1 (TSST-1) can cause a wide spectrum of immunopathological conditions, from toxic shock syndrome (TSS), a life-threatening illness, to neonatal TSS-like exanthematous disease (NTED), a self-limited mild disease. Leukocytoclastic vasculitis, which develops in the skin, is another immunopathological condition that is commonly observed in patients with IgA vasculitis during childhood. We report the case of an infant with an NTED-like exanthematous rash and IgA vasculitis-like purpuric skin lesions that were histopathologically diagnosed as leukocytoclastic vasculitis. A blood culture yielded methicillin-sensitive Staphylococcus aureus producing TSST-1, suggesting an etiological role in the aforementioned skin lesions

A polarimetric study of asteroids in comet-like orbits

International audienceContext. Asteroids in comet-like orbits (ACOs) consist of asteroids and dormant comets. Due to their similar appearance, it is challenging to distinguish dormant comets from ACOs via general telescopic observations. Surveys for discriminating dormant comets from the ACO population have been conducted via spectroscopy or optical and mid-infrared photometry. However, they have not been conducted through polarimetry. Aims: We conducted the first polarimetric research of ACOs. Methods: We conducted a linear polarimetric pilot survey for three ACOs: (944) Hidalgo, (3552) Don Quixote, and (331471) 1984 QY1. These objects are unambiguously classified into ACOs in terms of their orbital elements (i.e., the Tisserand parameters with respect to Jupiter TJ significantly less than 3). Three ACOs were observed by the 1.6 m Pirka Telescope from UT 2016 May 25 to UT 2019 July 22 (13 nights). Results: We found that Don Quixote and Hidalgo have polarimetric properties similar to comet nuclei and D-type asteroids (optical analogs of comet nuclei). However, 1984 QY1 exhibited a polarimetric property consistent with S-type asteroids. We conducted a backward orbital integration to determine the origin of 1984 QY1, and found that this object was transported from the main belt into the current comet-like orbit via the 3:1 mean motion resonance with Jupiter. Conclusions: We conclude that the origins of ACOs can be more reliably identified by adding polarimetric data to the color and spectral information. This study would be valuable for investigating how the ice-bearing small bodies distribute in the inner Solar System. Processed data (FITS) and lightcurves (data under Fig. B.1) are only available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/cat/J/A+A/658/A158</A

RNA-seq analysis, targeted long-read sequencing and in silico prediction to unravel pathogenic intronic events and complicated splicing abnormalities in dystrophinopathy

International audienc

Polarimetric properties of the near-Sun asteroid (155140) 2005 UD in comparison with other asteroids and meteoritic samples

The investigation of asteroids near the Sun is important for understanding the final evolutionary stage of primitive solar system objects. A near-Sun asteroid, (155140) 2005 UD, has orbital elements similar to those of (3200) Phaethon (the target asteroid for the JAXA's $DESTINY^+$ mission). We conducted photometric and polarimetric observations of 2005 UD and found that this asteroid exhibits a polarization phase curve similar to that of Phaethon over a wide range of observed solar phase angles ($\alpha = 20 - 105^\circ$) but different from those of (101955) Bennu and (162173) Ryugu (asteroids composed of hydrated carbonaceous materials). At a low phase angle ($\alpha \lesssim 30^\circ$), the polarimetric properties of these near-Sun asteroids (2005 UD and Phaethon) are consistent with anhydrous carbonaceous chondrites, while the properties of Bennu are consistent with hydrous carbonaceous chondrites. We derived the geometric albedo, $p_\mathrm{V} \sim 0.1$ (in the range of 0.088-0.109); mean $V$-band absolute magnitude, $H_\mathrm{V} = 17.54 \pm 0.02$; synodic rotational period, $T_\mathrm{rot} = 5.2388 \pm 0.0022$ hours (the two-peaked solution is assumed); and effective mean diameter, $D_\mathrm{eff} = 1.32 \pm 0.06$ km. At large phase angles ($\alpha \gtrsim 80^\circ$), the polarization phase curve are likely explained by the dominance of large grains and the paucity of small micron-sized grains. We conclude that the polarimetric similarity of these near-Sun asteroids can be attributed to the intense solar heating of carbonaceous materials around their perihelia, where large anhydrous particles with small porosity could be produced by sintering.Comment: 15 pages, 9 figures, accepted for publication in Monthly Notices of Royal Astronomical Society (MNRAS