Panax ginseng Modulates Cytokines in Bone Marrow Toxicity and Myelopoiesis: Ginsenoside Rg1 Partially Supports Myelopoiesis

In this study, we have demonstrated that Korean Panax ginseng (KG) significantly enhances myelopoiesis in vitro and reconstitutes bone marrow after 5-flurouracil-induced (5FU) myelosuppression in mice. KG promoted total white blood cell, lymphocyte, neutrophil and platelet counts and improved body weight, spleen weight, and thymus weight. The number of CFU-GM in bone marrow cells of mice and serum levels of IL-3 and GM-CSF were significantly improved after KG treatment. KG induced significant c-Kit, SCF and IL-1 mRNA expression in spleen. Moreover, treatment with KG led to marked improvements in 5FU-induced histopathological changes in bone marrow and spleen, and partial suppression of thymus damage. The levels of IL-3 and GM-CSF in cultured bone marrow cells after 24 h stimulation with KG were considerably increased. The mechanism underlying promotion of myelopoiesis by KG was assessed by monitoring gene expression at two time-points of 4 and 8 h. Treatment with Rg1 (0.5, 1 and 1.5 µmol) specifically enhanced c-Kit, IL-6 and TNF-α mRNA expression in cultured bone marrow cells. Our results collectively suggest that the anti-myelotoxicity activity and promotion of myelopoiesis by KG are mediated through cytokines. Moreover, the ginsenoside, Rg1, supports the role of KG in myelopoiesis to some extent

Investigation of Microwave Resonators for Monitoring Biological Parameters

This study focuses on feasibility analysis of different planar microwave resonators to monitor different biological parameters in human and animals. The methodology is based on the principle of change in resonance of the resonator due to the change in dielectric properties of surrounding tissues correlated with metabolism. Two Resonators namely Split Ring Resonator and Stepped Impedance Resonator are subjected to study. The resonance frequency of the resonator is found to be a function of their geometry and dielectric constant of the medium surrounding it. The responses of the resonators for various resonator experimental validation. The responses of resonators to different fluids are observed and the feasibility as an implantable sensor is investigated by embedding the resonators in animal tissue

Investigation of Microwave Resonators for Monitoring Biological Parameters

This study focuses on feasibility analysis of different planar microwave resonators to monitor different biological parameters in human and animals. The methodology is based on the principle of change in resonance of the resonator due to the change in dielectric properties of surrounding tissues correlated with metabolism. Two Resonators namely Split Ring Resonator and Stepped Impedance Resonator are subjected to study. The resonance frequency of the resonator is found to be a function of their geometry and dielectric constant of the medium surrounding it. The responses of the resonators for various resonator experimental validation. The responses of resonators to different fluids are observed and the feasibility as an implantable sensor is investigated by embedding the resonators in animal tissue

A Real-Time IVR Platform for Community Radio

Interactive Voice Response (IVR) platforms have been widely deployed in resource-limited settings. These systems tend to afford asynchronous push interactions, and within the context of health, provide medication reminders, descriptions of symptoms and tips on self-management. Here, we present the development of an IVR system for resource-limited settings that enables real-time, synchronous interaction. Inspired by community radio, and calls for health systems that are truly local, we developed "Sehat ki Vaani". Sehat ki Vaani is a real-time IVR platform that enables hosting and participation in radio chat shows on community-led topics. We deployed Sehat ki Vaani with two communities in North India on topics related to the management of Type 2 diabetes and maternal health. Our deployments highlight the potential for synchronous IVR systems to offer community connection and localised sharing of experience, while also highlighting the complexity of producing, hosting and participating in radio shows in real time through IVR. We discuss the relative strengths and weaknesses of synchronous IVR systems, and highlight lessons learnt for interaction design in this area

Establishing Integrated Agriculture-Nutrition Programmes to Diversify Household Food and Diets in Rural India

Agriculture is the predominant livelihood for 70 % of the population living in rural India, and food expenses occupy a major proportion of their household budget. Rural household diets suggest that agricultural growth has contributed to increasing calorie intake with very minimal effect on the intake of protein and micronutrients. This in turn causes weak positive impact of agriculture on household dietary diversity and nutrient adequacy. Given the prevalence of high levels of under-nutrition and a large population dependent on agriculture, recent thinking globally on leveraging agriculture for nutrition security has encouraged the agricultural sector to realign its focus not only to increase food production, but also to address under-nutrition. Against this background, an exploratory study was conducted in resource poor villages of Wardha and Koraput districts in the states of Maharashtra and Odisha in India, to investigate how location-specific Farming System for Nutrition (FSN) interventions can potentially improve the diversity of household diets and nutrition outcomes. A detailed baseline study was undertaken to identify the existing disconnect between agriculture-nutrition linkages. In the study locations, the proportion of all forms of under-nutrition, vitamin A deficiency and iron-deficiency anaemia among children 18 years) significantly increased as the dietary diversity score (DDS) decreased from high to low. In Koraput, the prevalence rate of anaemia in adolescent girls and women significantly increased, as the DDS decreased. We conclude that food and diets lacking diversity and without nutrition-sensitive farming systems (either commercial- or subsistence-based) may not be appropriate to improve household nutrition and health status. Our findings provide a basis for structuring integrated agriculture-nutrition programmes or a FSN approach to diversifying household food and diets, for improving nutrition and health in India