The Lantern Vol. 54, No. 2, Spring 1988

• Burning the Christmas Guests • A Song in Time • I Ask a Question • As If Raggedy Anne • One Man\u27s Escape • Gypsy Caravan • Apartment 14B • The College Inferno • Somewhere Under Manhattan • Trumped • Sunday • In Quest of Creativity • Imperfect Healing • The Game • The Hunger • Peanuts on the Beach • Battlefield Prom • Confessions of the Untrained Eye • Animal Attraction • Street Lamps • Hey, Old Man • In Search of Self-Actualization • Cousin Joe Bob\u27s First Visit to Pulsationshttps://digitalcommons.ursinus.edu/lantern/1132/thumbnail.jp

The Lantern Vol. 55, No. 1, Fall 1988

• The Third Grade Gorilla • Friend, I Am Not Yet A Poet • Twisted • The Final Journey • Ritu Miltonis • Hearthside • The Ogre • O Indestructible Everlasting • December 1, 1988 • Our Church • Louise • Gazebo For Learned Women • Hanging Mirror • Of Football and Flashlights • The Ragged Brown Peasant • Judgement of the Serpent • Sidewalk Wars • I Guess That\u27s Why I Went Awayhttps://digitalcommons.ursinus.edu/lantern/1133/thumbnail.jp

The Lantern Vol. 55, No. 1, Fall 1988

• The Third Grade Gorilla • Friend, I Am Not Yet A Poet • Twisted • The Final Journey • Ritu Miltonis • Hearthside • The Ogre • O Indestructible Everlasting • December 1, 1988 • Our Church • Louise • Gazebo For Learned Women • Hanging Mirror • Of Football and Flashlights • The Ragged Brown Peasant • Judgement of the Serpent • Sidewalk Wars • I Guess That\u27s Why I Went Awayhttps://digitalcommons.ursinus.edu/lantern/1133/thumbnail.jp

The Lantern Vol. 54, No. 1, Fall 1987

• Darkside • Reflections on a Subway Ride • Demand for Love • Music Man • Something Wild • The Nice Guy\u27s Story • The Picnic • Internalize • Days When You Feel Like Wonder Bread • II • A Tear • In Pursuit of Beauty • A Walk Down Sycamore Lane • A Wish • Sins of Omission • Pessimism • And the Sky Cracked • The Clock Strikes • Invinciblehttps://digitalcommons.ursinus.edu/lantern/1131/thumbnail.jp

The Lantern Vol. 55, No. 2, Spring 1989

• Sitting On a Summer Bench • A Perfect Daughter I Could Never Be • Roots And Wings • Sensai • The Last Three Weeks of August • Grown Up • What Size? • Hidden Colors • Victims • I Listen for Your Voice • Thoughts • In Remembrance of Grandpa • Jesus Christ, Terry • Penance • The Guys Are Driving High • You and Me and Big Ginko • The Good Ole Days of Seventh Grade • Cycles • Leather Upholstery • Chicago Kris in Cairo • Lemonade and Medicine • My Last 7:15 Communionhttps://digitalcommons.ursinus.edu/lantern/1134/thumbnail.jp

The Lantern Vol. 56, No. 2, Spring 1990

• Brasil • Plastic Flowers • Be a Pepper • Grunge • Handling the Responsibility • Returning to the Forest • How Nice • Nooze • Emma • Restoration • Chestnuts • Frozen Moments • Once Upon A • Clipped Wings • Gerard Manley Hopkins • Roaches • In Grand Central • The Steelville Shark • Panama 1989 • Betrayal • Violations • Detourhttps://digitalcommons.ursinus.edu/lantern/1136/thumbnail.jp

The Lantern Vol. 53, No. 1, Fall 1986

• Living In-Sanity • Sentence of Dawn • Addict • Where Do They Come From? • Midnight Hags Astride • Escape • Here I Sit • A Minor Key • To Picasso\u27s Old Guitarist • Nothing More • Love or Futility • A Few Inches • My Only Gift • Reserved • A Message to a Disillusioned Friend • Doing it the Hard Way • The Wall • A Look Ahead at a Look Behind • Fantasy Secret • Lisa • Caesar\u27s Last Words • There\u27s a Grouse in My House • If You Want Me • The Education of a Samaritan • Death of Illusion • I Walked and Pondered • A Woman Walked Past Him and He Smiled • Betrayal • Blindness • Innocence Unveiled • Amandahttps://digitalcommons.ursinus.edu/lantern/1129/thumbnail.jp

LINE-1 Evasion of Epigenetic Repression in Humans

Epigenetic silencing defends against LINE-1 (L1) retrotransposition in mammalian cells. However, the mechanisms that repress young L1 families and how L1 escapes to cause somatic genome mosaicism in the brain remain unclear. Here we report that a conserved Yin Yang 1 (YY1) transcription factor binding site mediates L1 promoter DNA methylation in pluripotent and differentiated cells. By analyzing 24 hippocampal neurons with three distinct single-cell genomic approaches, we characterized and validated a somatic L1 insertion bearing a 3' transduction. The source (donor) L1 for this insertion was slightly 5' truncated, lacked the YY1 binding site, and was highly mobile when tested in\ua0vitro. Locus-specific bisulfite sequencing revealed that the donor L1 and other young L1s with mutated YY1 binding sites were hypomethylated in embryonic stem cells, during neurodifferentiation, and in liver and brain tissue. These results explain how L1 can evade repression and retrotranspose in the human body