22 research outputs found

    Parent-offspring resemblance for educational attainment reduces with increased social class in a global sample: evidence for the compensatory advantage hypothesis

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    IntroductionThe degree to which (self-reported) social class predicts parent-offspring resemblance for educational attainment (EA) is examined in a globally representative dataset of 69,116 individuals sourced from 56 countries.MethodsA hierarchical general linear model is used to predict participant EA with the two-way interaction between class and parental EA, after controlling for regional effects, the main effects of age, class, parental EA, and interactions among these.ResultsSocial class-by-parental EA interaction negatively predicts participant EA (semipartial r = −0.04, 95% CI = −0.05 to −0.03), meaning that among those who report belonging to a “higher” social class, the degree of parent-offspring resemblance for EA is reduced, contrary to the Scarr-Rowe hypothesis, which holds that genetic influences on cognitive ability and related phenotypes (captured here in part by parent-offspring resemblance) should be greater among those from higher socioeconomic status (SES) backgrounds. These results replicate using a quantile regression model, where it was found that among those with lower social class ordinals, the strength of the parent-participant EA association is significantly stronger relative to those in the highest ordinal. No significant sex differences are present.DiscussionThese findings are consistent with the compensatory advantage hypothesis, which predicts decreased heritability of EA and related phenotypes among affluent families, as increased access to educational resources should enhance opportunities for cognitive growth in a way that compensates for intrinsic disadvantages

    IMPACT-Global Hip Fracture Audit: Nosocomial infection, risk prediction and prognostication, minimum reporting standards and global collaborative audit. Lessons from an international multicentre study of 7,090 patients conducted in 14 nations during the COVID-19 pandemic

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    Data from: What caused over a century of decline in general intelligence? Testing predictions from the genetic selection and neurotoxin hypotheses

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    Several converging lines of evidence indicate that general intelligence (g) has declined in Western populations. The causes of these declines are debated. Here, two hypotheses are tested: (1) selection acting against genetic variants that promote g causes the decline and (2) the presence of neurotoxic pollution in the environment causes the decline. A linear mixed model was devised to test (1) and (2), in which the secular decline in a “heritable g” (g.h) chronometric factor (comprised of convergent indicators of simple reaction time, working memory, utilization frequencies of high difficulty and also social-intelligence-indicating vocabulary items and per capita macro-innovation rates) was predicted using a neurotoxin chronometric factor (comprised of convergent secular trends among measures of lead, mercury and dioxin + furan pollution, in addition to alcohol consumption) and a polygenic score chronometric factor (comprised of polygenic score means for genetic variants predictive of g, sourced from US and Icelandic age-stratified cohorts). Bivariate correlations revealed that (other than time) only the polygenic score factor was significantly associated with declining g.h (r = .393, p < .05 vs. .033, ns for the neurotoxin factor). Using a hierarchical linear mixed model approach incorporating 25 year lags between the predictors and g.h, time period, operationalized categorically as fifths of a century, accounted for the majority of the variance in the decline in g.h (partial η^2 = .584, p < .05). Net of time period and neurotoxins, changing levels of polygenic scores also significantly predicted variance in the decline in g.h (partial η^2 = .253, p < .05); however, changing levels of neurotoxins did not significantly predict variance in g.h net of time (partial η^2 = .027 ns). Within-period analysis indicates that the independent significant positive effect of the polygenic score factor on g.h was restricted to the third fifth of a century period (β = .202, p < .05)

    Treatment of renal calculi by lithotripsy: minimising short-term shock wave induced renal damage by using antioxidants

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    Treatment with extracorporeal shock wave lithotripsy (ESWL), the preferred method of treating kidney stones <3 cm in size, has been shown to induce silent and often self-limiting acute and chronic lesions in the kidneys and adjacent organs. We conducted a randomized clinical trial to determine whether ESWL produces ischaemia and reperfusion injury in the kidneys and whether oral administration of antioxidants reduces the degree of short-term renal injury in patients treated with ESWL. The study included 120 patients with renal stones (1–3 cm in size) treated with ESWL. The patients were divided into three groups—patients in group A (n = 39) served as a control group and were not given any antioxidants; patients in group B (n = 41) were given two capsules of antioxidants “Nature Made r” 2 h before ESWL, and 2 and 8 h after ESWL; and patients in group C (n = 40) were given two capsules of the antioxidants 2 and 8 h after ESWL. Double ‘J’ stents were inserted in patients before treatment with ESWL. Blood and urine samples were obtained from all patients just before the start of treatment with ESWL, and at 2 and 24 h and on 7th and 28th day after ESWL. Serum levels of malondialdehyde (MDA), α-tocopherol, cholesterol, albumin and ascorbic acid, and α-tocopherol/cholesterol ratio were determined. Urinary levels of albumin and β2 microglobulin were also determined as measures of renal tubular injury. At 24 h after ESWL, patients given antioxidants (groups B + C) had significantly reduced mean serum concentration of MDA (P < 0.001); higher levels of serum ascorbic acid (P < 0.001) and serum albumin (P < 0.001); lower α-tocopherol/cholesterol ratio, lower urinary albumin and β2 microglobulin levels compared with patients who did not receive antioxidants (group A). These findings suggest that treatment with ESWL generates free radicals through ischaemic/reperfusion injury mechanism, and that oral administration of antioxidant may protect these patients from short term renal injury caused by ESWL
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