Statistical Storm Time Examination Of Mlt-Dependent Plasmapause Location Derived From Image Euv

The location of the outer edge of the plasmasphere (the plasmapause) as a function of geomagnetic storm time is identified and investigated statistically in regard to the solar wind driver. Imager for Magnetopause‐to‐Aurora Global Exploration (IMAGE) extreme ultraviolet (EUV) data are used to create an automated method that locates and extracts the plasmapause. The plasmapause extraction technique searches a set range of possible plasmasphere densities for a maximum gradient. The magnetic local time (MLT)‐dependent plasmapause results are compared to manual extraction results. The plasmapause results from 39 intense storms are examined along a normalized epoch storm timeline to determine the average plasmapause L shell as a function of MLT and storm time. The average extracted plasmapause L shell follows the expected storm time plasmapause behavior. The results show that during the main phase, the plasmapause moves earthward and a plasmaspheric drainage plume forms near dusk and across the dayside during strong convection. During the recovery phase, the plume rejoins the corotationally driven plasma while the average plasmapause location moves farther from the Earth. The results are also examined in terms of the solar wind driver. We find evidence that shows that the different categories of solar wind drivers result in different plasmaspheric configurations. During magnetic cloud‐driven events the plasmaspheric drainage plume appears at the start of the main phase. During sheath‐driven events the plume forms later but typically extends further in MLT.Key PointsDeveloped an automated procedure to extract plasmapause from IMAGE EUV imagesValidate and evaluate results using statistical analysis of 39 intense stormsShow that plasmasphere dynamics vary systematically with CME‐v‐CIR drivin

Superconducting properties of Nb thin films deposited on porous silicon templates

Porous silicon, obtained by electrochemical etching, has been used as a substrate for the growth of nanoperforated Nb thin films. The films, deposited by UHV magnetron sputtering on the porous Si substrates, inherited their structure made of holes of 5 or 10 nm diameter and of 10 to 40 nm spacing, which provide an artificial pinning structure. The superconducting properties were investigated by transport measurements performed in the presence of magnetic field for different film thickness and substrates with different interpore spacing. Perpendicular upper critical fields measurements present peculiar features such as a change in the H_c2(T) curvature and oscillations in the field dependence of the superconducting resistive transition width at H=1 Tesla. This field value is much higher than typical matching fields in perforated superconductors, as a consequence of the small interpore distance.Comment: accepted for publication on Journal of Applied Physic

Twenty-Seven Y-Chromosome Short Tandem Repeats Analysis of Italian Mummies of the 16th and 18th Centuries: An Interdisciplinary Research

Roccapelago (MO) is a small village located in the Northern Central Apennines, with a population of 31 inhabitants (2014). In 2010, more than 400 individuals dated between the end of the 16th and the 18th century, many of which partially mummified, were discovered in the crypt of the church. This small village, because of its geographical location and surrounding environment, seems to possess the characteristics of a genetic isolate, useful for population genetics and genealogical analyses. Thus, a diachronic study of DNA aimed at investigating the structure and dynamics of the population of Roccapelago over the about 4 centuries, was conducted by analyzing ancient and modern inhabitants of the village. The 14 modern samples were selected by considering both the founder surnames of the village, identified thanks to the study of parish registers, and the grandparent’s criterion. From 25 ancient mummies, morphologically assigned to male individuals, the petrous bone, that harbors high DNA amounts, was selected for the DNA extraction. The quantification and qualitative assessment of total human male DNA were evaluated by a real-time PCR assay using the Quantifiler Trio DNA Quantification Kit and multiplex PCR of 27 Y-chromosome short tandem repeat (Y-STR) markers included in the Yfiler Plus PCR Amplification Kit, with seven rapidly mutating Y-STR loci for improving discrimination of male lineages, was performed to genotype the samples. Y-STRs were analyzed according to the criteria of ancient DNA (aDNA) analysis to ensure that authentic DNA typing results were obtained from these ancient samples. The molecular analysis showed the usefulness of the Y chromosome to identify historically relevant remains and discover patterns of relatedness in communities moving from anthropology to genetic genealogy and forensics

COVID-19 vaccine mRNABNT162b2 elicits human antibody response in milk of breastfeeding women

Objective: The objective of this research is to demonstrate the release of SARS-CoV-2 Spike (S) antibodies in human milk samples obtained by patients who have been vaccinated with mRNABNT162b2 vaccine. Methods: Milk and serum samples were collected in 10 volunteers 20 days after the first dose and 7 seven days after the second dose of the mRNABNT162b2 vaccine. Anti-SARS-CoV-2 S antibodies were measured by the Elecsys® Anti-SARS-CoV-2 S ECLIA assay (Roche Diagnostics AG, Rotkreuz, Switzerland), a quantitative electrochemiluminescence immunometric method. Results: At first sample, anti-SARS-CoV-2 S antibodies were detected in all serum samples (103.9 ± 54.9 U/mL) and only in two (40%) milk samples with a low concentration (1.2 ± 0.3 U/mL). At the second sample, collected 7 days after the second dose, anti-SARS-CoV-2 S antibodies were detected in all serum samples (3875.7 ± 3504.6 UI/mL) and in all milk samples (41.5 ± 47.5 UI/mL). No correlation was found between the level of serum and milk antibodies; the milk antibodies/serum antibodies ratio was on average 2% (range: 0.2–8.4%). Conclusion: We demonstrated a release of anti-SARS-CoV-2 S antibodies in the breast milk of women vaccinated with mRNABNT162b2. Vaccinating breastfeeding women could be a strategy to protect their infants from COVID-19 infection

Unusual MRI findings in an immunocompetent patient with EBV encephalitis: a case report

BACKGROUND: It is well-known that Epstein-Barr virus (EBV) can affect the central nervous system (CNS). CASE PRESENTATION: Herein the authors report unusual timely Magnetic Resonance Imaging (MRI) brain scan findings in an immunocompetent patient with EBV encephalitis. Diffusion weighted MRI sequence performed during the acute phase of the disease was normal, whereas the Fast Relaxation Fast Spin Echo T2 image showed diffuse signal intensity changes in white matter. The enhancement pattern suggested an inflammatory response restricted to the brain microcirculation. Acyclovir and corticosteroid therapy was administered. After three weeks, all signal intensities returned to normal and the patient showed clinical recovery. CONCLUSION: This report demonstrates that EBV in an immunocompetent adult can present with diffuse, reversible brain white matter involvement in the acute phase of mononucleosis. Moreover, our case suggests that a negative DWI sequence is associated with a favorable improvement in severe EBV CNS infection. More extensive studies are needed to assess what other instrumental data can help to distinguish viral lesions from other causes in the acute phase of diseas

The signalling channel of Central Bank interventions:modelling the Yen/US dollar exchange rate

This paper presents a theoretical framework analysing the signalling channel of exchange rate interventions as an informational trigger. We develop an implicit target zone framework with learning in order to model the signalling channel. The theoretical premise of the model is that interventions convey signals that communicate information about the exchange rate objectives of the central bank. The model is used to analyse the impact of Japanese FX interventions during the period 1999--2011 on the yen/US dollar dynamics

Genetic history of Calabrian Greeks reveals ancient events and long term isolation in the Aspromonte area of Southern Italy

Calabrian Greeks are an enigmatic population that have preserved and evolved a unique variety of language, Greco, survived in the isolated Aspromonte mountain area of Southern Italy. To understand their genetic ancestry and explore possible effects of geographic and cultural isolation, we genome-wide genotyped a large set of South Italian samples including both communities that still speak Greco nowadays and those that lost the use of this language earlier in time. Comparisons with modern and ancient populations highlighted ancient, long-lasting genetic links with Eastern Mediterranean and Caucasian/Near-Eastern groups as ancestral sources of Southern Italians. Our results suggest that the Aspromonte communities might be interpreted as genetically drifted remnants that departed from such ancient genetic background as a consequence of long-term isolation. Specific patterns of population structuring and higher levels of genetic drift were indeed observed in these populations, reflecting geographic isolation amplified by cultural differences in the groups that still conserve the Greco language. Isolation and drift also affected the current genetic differentiation at specific gene pathways, prompting for future genome-wide association studies aimed at exploring trait-related loci that have drifted up in frequency in these isolated groups

On the origin of lowâ energy electrons in the inner magnetosphere: Fluxes and pitchâ angle distributions

Accurate knowledge of the plasma fluxes in the inner magnetosphere is essential for both scientific and programmatic applications. Knowledge of the lowâ energy electrons (approximately tens to hundreds of eV) in the inner magnetosphere is particularly important since these electrons are acted upon by various physical processes, accelerating the electrons to higher energies, and also causing their loss. However, measurements of lowâ energy electrons are challenging, and as a result, this population has been somewhat neglected previously. This study concerns observations of lowâ energy electrons made by the Helium Oxygen Proton Electron instrument on board the Van Allen Probes satellites and also observations from geosynchronous orbit made by the Magnetospheric Plasma Analyzer on board Los Alamos National Laboratory satellites. The fluxes of electrons from ~30â eV to 1â keV are quantified as a function of pitchâ angle, McIlwain L parameter, and local time for both quiet and active periods. Results indicate two sources for lowâ energy electrons in this energy range: the lowâ energy tail of the electron plasma sheet and the highâ energy tail of the dayside ionosphere. These populations are identified primarily as a result of their different pitchâ angle distributions. Fieldâ aligned outflows from the dayside ionosphere are observed at all L shells during quiet and active periods. Our results also demonstrate that the dayside electron fieldâ aligned fluxes at ~30â eV are particularly strong between L values of 6 and 7, indicating an enhanced source within the polar ionosphere.Key PointsLowâ energy electrons (tens to hundreds of eV) originate from two main sources: the ionosphere and the plasma sheetLowâ energy electrons pervade the inner magnetosphere where they can drive waveâ particle interactionsFluxes of electrons from ~30â eV to 1â keV are quantified by pitchâ angle, L value, and local time for both quiet and active periodsPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136397/1/jgra53305_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136397/2/jgra53305.pd

Ancient human mitochondrial genomes from Bronze Age Bulgaria: new insights into the genetic history of Thracians

Abstract One of the best documented Indo-European civilizations that inhabited Bulgaria is the Thracians, who lasted for more than five millennia and whose origin and relationships with other past and present-day populations are debated among researchers. Here we report 25 new complete mitochondrial genomes of ancient individuals coming from three necropolises located in different regions of Bulgaria – Shekerdja mogila, Gabrova mogila and Bereketska mogila – dated to II-III millennium BC. The identified mtDNA haplogroup composition reflects the mitochondrial variability of Western Eurasia. In particular, within the ancient Eurasian genetic landscape, Thracians locate in an intermediate position between Early Neolithic farmers and Late Neolithic-Bronze Age steppe pastoralists, supporting the scenario that the Balkan region has been a link between Eastern Europe and the Mediterranean since the prehistoric time. Spatial Principal Component Analysis (sPCA) performed on Thracian and modern mtDNA sequences, confirms the pattern highlighted on ancient populations, overall indicating that the maternal gene pool of Thracians reflects their central geographical position at the gateway of Europe

The determinants of vulnerability to currency crises: country-specific factors versus regional factors

We investigate the determinants of exchange market pressures (EMP) for some new EU member states at both the national and regional levels, where macroeconomic and financial variables are considered as potential sources. The regional common factors are extracted from these variables by using dynamic factor analysis. The linear empirical analysis, in general, highlights the importance of country-specific factors to defend themselves against vulnerability in their external sectors. Yet, given a significant impact of the common component in credit on EMP, a contagion effect is apparent through the conduit of credit market integration across these countries under investigation