737 research outputs found
Are baseline ultrasound and mammographic features associated with rates of pathological completes response in patients receiving neoadjuvant chemotherapy for breast cancer?
Comment on MaaniHessari, N.; van Schalkwyk, M.C.; Thomas, S.; Petticrew, M. Alcohol Industry CSR Organisations:What Can Their Twitter Activity Tell Us about Their Independence and Their Priorities? A Comparative Analysis. Int. J. Environ. Res. Public Health 2019, 16, 892
P and K additions enhance canopy N retention and accelerate the associated leaching
This study evaluated the interactive effects of combined phosphorus (P) and potassium (K) additions on canopy nitrogen (N) retention (CNR) and subsequent canopy leaching at a long-term N manipulation site on Whim bog in south Scotland. Ambient deposition is 8 kg N ha-1 year-1 and an additional 8, 24, and 56 kg N ha-1 year-1 of either ammonium (NH4+) or nitrate (NO3-) with or without P and K has been applied over 11 years. Throughfall N deposition below Calluna vulgaris and foliar N and P concentrations were assessed. Results showed that 60% for low dose and 53% for high dose of NO3- contrasting with 80% for low dose and 38% for high dose of NH4+ onto Calluna was retained by Calluna canopy. The CNR was enhanced by P and K addition in which 84% of NO3 - and 83% of NH4+ for high dose were retained.
CNR for NO3- increased the canopy leaching of dissolved organic N (DON) and associated organic anions. NH4+ retention increased canopy leaching of magnesium and calcium through ion exchange. Even over 11-years N exposure without P and K, foliage 29 N:P ratio of Calluna did not increase, suggesting that N exposure did not lead to N saturation of Calluna at Whim bog. Our study concluded that increases in P and K availability enhance CNR of Calluna, but accelerate the associated canopy leaching of DON and base cations, depending on foliar N status
Virulence, drug sensitivity and transmission success in the rodent malaria, Plasmodium chabaudi.
Here, we test the hypothesis that virulent malaria parasites are less susceptible to drug treatment than less virulent parasites. If true, drug treatment might promote the evolution of more virulent parasites (defined here as those doing more harm to hosts). Drug-resistance mechanisms that protect parasites through interactions with drug molecules at the sub-cellular level are well known. However, parasite phenotypes associated with virulence might also help parasites survive in the presence of drugs. For example, rapidly replicating parasites might be better able to recover in the host if drug treatment fails to eliminate parasites. We quantified the effects of drug treatment on the in-host survival and between-host transmission of rodent malaria (Plasmodium chabaudi) parasites which differed in virulence and had never been previously exposed to drugs. In all our treatment regimens and in single- and mixed-genotype infections, virulent parasites were less sensitive to pyrimethamine and artemisinin, the two antimalarial drugs we tested. Virulent parasites also achieved disproportionately greater transmission when exposed to pyrimethamine. Overall, our data suggest that drug treatment can select for more virulent parasites. Drugs targeting transmission stages (such as artemisinin) may minimize the evolutionary advantage of virulence in drug-treated infections
Shear wave elastography of breast cancer:sensitivity according to histological type in a large cohort
Aquatic Mammals
Abstract The waters of the Inner Moray Firth were designated a Special Area of Conservation (SAC) in 2005 for the conservation of the bottlenose dolphin (Tursiops truncatus) in northeast Scotland. However, the long-term conservation of this population requires monitoring throughout its entire known range. Opportunistic photo-identification of bottlenose dolphins occurred during 65 cetacean surveys conducted between 1999 and 2008 in the coastal waters of Aberdeenshire. A total of 88 bottlenose dolphin photo-identification encounters resulted in one to 45 animals identified per survey. The minimum annual total population size based on marked animals alone was 62 individuals, and the discovery curve indicated that the population has not yet been adequately sampled. Of 40 highly distinctive adult animals, the annual sighting rate ranged from 0.167 (seen in one year only) to 1.000 (seen every year). The cumulative monthly sighting rate varied from 0.091 (photographed in one month only) to 0.636 (photographed during seven of the 11 combined survey months in the 2001 to 2008 study period). The overall seasonal occurrence of dolphins off Aberdeenshire peaked during May and June, when 65% of distinctively marked animals were recorded per month (combined data for 2001 to 2008). Eighty-four percent of distinctively marked dolphins were matched with those photographed in the Inner Moray Firth, while 93% were matched with those photographed in the southern Outer Moray Firth. Despite its opportunistic nature, the photo-identification study provided valuable information on a population of bottlenose dolphins in a poorly studied part of their range. The high percentage of matches with dolphins from the Moray Firth SAC indicates that over half of the known northeast Scotland population uses the Aberdeenshire region, and some individuals do so regularly. The frequent occurrence off Aberdeen of bottlenose dolphins from a protected SAC has repercussions for the conservation and management of the population and for the effectiveness of the SAC for their longterm protection
Supporting decision-making by companies in delivering their climate net-zero and nature recovery commitments: synthesizing current information and identifying research priorities in rainforest restoration
Many companies are making ambitious pledges to achieve positive impacts for climate and nature by financing restoration of carbon- and biodiversity- rich natural habitats. However, companies cannot make evidence-based choices that will deliver successful restoration if the scientific information required to guide investment has not been synthesised in a way that they can use, or there are knowledge gaps. To explore this issue, share information, and identify knowledge gaps and research priorities, we bring together researchers, a conservation NGO and a multinational consumer goods company (Unilever), focusing on Southeast Asian rainforests. These habitats offer significant restoration opportunities for carbon and biodiversity in areas that have been degraded by commercial logging and agriculture. We find that procedures for carbon restoration are much better developed than those for biodiversity, and that new research is urgently needed to deliver evidence-based biodiversity restoration. Companies need to be confident that their actions are fit-for-purpose to meet their environmental pledges. Achieving successful restoration outcomes will require co-designed projects with the potential to deliver positive co-benefits for carbon, biodiversity and local livelihoods
Sniffer ER26. Model validation using monitored data from Scottish poultry farms
The report outlines the bespoke monitoring conducted for the validation of the SCAIL tool in order to better assess that the tool provides realistic yet conservative results. Two farm sites were selected for the validation monitoring. The study collected data for odour, ammonia and airborne particulate data as well as recording on-site meteorological information. In conclusion the SCAIL-Agriculture model was found to broadly meet recognised acceptability criteria for the prediction of ammonia, PM10 and odour concentration arising from farm buildings. There are however a number of areas where further research could clearly improve the assessment of agricultural sources
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