Assessing and Responding to COVID-19 Pandemic Nutrition and Wellness Impacts on Iowans

The COVID-19 pandemic has increased the need for indirect Extension programming. To ensure a consumer-focused response, we gathered data from 452 survey respondents regarding how the pandemic was affecting their food-related and health behaviors. The majority reported obtaining their food from a grocery store as they had prior to the pandemic, albeit less frequently, and having increased their home food preparation. Due to the pandemic, respondents were less physically active and more stressed and were seeking reliable nutrition and wellness information. We describe how we were able to facilitate an immediate response by repackaging and adapting existing programming to meet pressing client needs, and we identify broader implications of our work

Food Retailers’ Perspectives on Pilot Program Strategies to Promote Healthy Eating in SNAP Participants

Food retailers are key stakeholders in the development, implementation, and effectiveness of Supplemental Nutrition Assistance Program (SNAP) nutrition pilot programs. Qualitative interviews were conducted to gather insight from food retailers regarding the feasibility of proposed strategies to improve food choices among SNAP participants. Two corporate and six local-level food retailer managers were identified for interviews based on SNAP participation, rural- urban code, and type of food retail settings in the selected counties. Qualitative thematic analysis was performed by four research team members, and themes were identified via consensus. Marketing, incentive, and disincentive program models were well-received, while restriction and stocking standards models were less well-received. Food retailers viewed simple programs with easy implementation and educational components positively. Driving sales and programs that align with corporate and social responsibility goals were important factors related to willingness to participate in pilot programs. Insights from this present study can inform future pilot programs and promote food retailer buy-in

Lessons Learned: Recruiting Aging Adults for Research

Aging adults are the fastest-growing population in the United States, but they are underrepresented in health care research. Evidence-based decisions for aging adults need to be made using research done with this population. However, recruiting aging adults into research has many challenges. This article presents multiple cases of recruiting aging adults into nutrition research studies in 3 different US geographic locations. The challenges, successes, and lessons learned are presented. The lessons learned can provide guidance to others already doing research with aging adults and those clinical and community dietitians who want to start doing research with aging adults

Human Consumption of Microplastics

Microplastics are ubiquitous across ecosystems, yet the exposure risk to humans is unresolved. Focusing on the American diet, we evaluated the number of microplastic particles in commonly consumed foods in relation to their recommended daily intake. The potential for microplastic inhalation and how the source of drinking water may affect microplastic consumption were also explored. Our analysis used 402 data points from 26 studies, which represents over 3600 processed samples. Evaluating approximately 15% of Americans’ caloric intake, we estimate that annual microplastics consumption ranges from 39000 to 52000 particles depending on age and sex. These estimates increase to 74000 and 121000 when inhalation is considered. Additionally, individuals who meet their recommended water intake through only bottled sources may be ingesting an additional 90000 microplastics annually, compared to 4000 microplastics for those who consume only tap water. These estimates are subject to large amounts of variation; however, given methodological and data limitations, these values are likely underestimates

Additive genetic and environmental variation interact to shape the dynamics of seasonal migration in a wild bird population

We thank everyone who contributed to long-term field data collection, particularly Raymond Duncan, Sarah Fenn, Hannah Grist, Calum Scott, Jenny Sturgeon, Moray Souter, John Anderson, and Harry Bell; and thank NatureScot for allowing work on the Isle of May National Nature Reserve, and Isle of May Bird Observatory Trust for supporting the longterm ringing of shags. We thank Stefanie Muff for helpful discussions, and Rita Fortuna and Thomas R. Haaland for useful comments on a manuscript draft. The current study was funded by Natural Environment Research Council (NERC; awards NE/M005186/1, NE/R000859/1, and NE/R016429/1 as part of the UK-SCaPE program delivering National Capability), Norwegian Research Council (SFF-III grant 223257, FRIPRO grant 313570), NTNU and University of Aberdeen. Analyses were performed using the IDUN cluster of NTNUPeer reviewedPublisher PD

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity.

hIAPP fibrils are associated with Type-II Diabetes, but the link of hIAPP structure to islet cell death remains elusive. Here we observe that hIAPP fibrils are cytotoxic to cultured pancreatic β-cells, leading us to determine the structure and cytotoxicity of protein segments composing the amyloid spine of hIAPP. Using the cryoEM method MicroED, we discover that one segment, 19-29 S20G, forms pairs of β-sheets mated by a dry interface that share structural features with and are similarly cytotoxic to full-length hIAPP fibrils. In contrast, a second segment, 15-25 WT, forms non-toxic labile β-sheets. These segments possess different structures and cytotoxic effects, however, both can seed full-length hIAPP, and cause hIAPP to take on the cytotoxic and structural features of that segment. These results suggest that protein segment structures represent polymorphs of their parent protein and that segment 19-29 S20G may serve as a model for the toxic spine of hIAPP

6-De­oxy-6-fluoro-d-galactose

The crystal structure unequivocally confirms the relative stereochemistry of the title compound, C6H11FO5. The absolute stereochemistry was determined by the use of d-galactose as the starting material. The compound exists as a three-dimensional O—H⋯O hydrogen-bonded network with each mol­ecule acting as a donor and acceptor for four hydrogen bonds

Uplift of the Bolivian orocline coastal areas based on geomorphologic evolution of marine terraces and abrasion surfaces: preliminary results

The southern Pacific coast morphology and especially the presence of marine surfaces gives information on the dynamics of Andean forearc evolution from the Neogene. Along most of the Southern Peru and Northern Chilean coasts, discontinuous uplifts are recorded by marine terraces and marine abrasion surfaces; they have thus, preserved a record of eustatic sea level changes and the uplift history of the coastal area in the Andean forearc. One approach to study the tectonic history of the Andean forearc is to identify its effects in marine sedimentation or erosion patterns along the coastal area. To investigate these processes, the Neogene marine formations are studied in various coastal sections either in southern Peru, at Chala (15°50'S) and Ilo (17°32'S-17°48'S), situated above a steep subduction segment and at San Juan de Marcona (15°20'S), situated above the southern part of the Nazca ridge; or in Chile, from Tongoy (30°15'S) to Los Vilos (31°55'S), situated above a flat subduction segment (Fig.1). We chose various sites from each branch of the Arica bend in order to sample possibly different time spans during the Neogene and different response of the continental plate to the subduction process. Various studies were already undertaken on such problems either in Peru or Chile but mainly leaded to the datation of the 5th isotopic stage. So, differential GPS and cosmogenic datations are pursued in order to propose robust ages on these sites and subtract the effects of eustatic sea-level changes from local curves, identifying tectonic uplifts

Extracorporeal membrane oxygenation support after the Fontan operation

ObjectiveExtracorporeal membrane oxygenation has been used to support children with cardiac failure after the Fontan operation. Mortality is high, and causes of mortality remain unclear. We evaluated the in-hospital mortality and factors associated with mortality in these patients.MethodsExtracorporeal Life Support Organization registry data on patients requiring extracorporeal membrane oxygenation after the Fontan operation from 1987 to 2009 were retrospectively analyzed. Demographics and extracorporeal membrane oxygenation data were compared for survivors and nonsurvivors. A multivariable logistic regression model was used to identify factors associated with mortality.ResultsOf 230 patients, 81 (35%) survived to hospital discharge. Cardiopulmonary resuscitation was more frequent (34% vs 17%, P = .04), and median fraction of inspired oxygen concentration was higher (1 [confidence interval, 0.9–1.0] vs 0.9 [confidence interval, 0.8–1.0], P = .03) before extracorporeal membrane oxygenation in nonsurvivors compared with survivors. Extracorporeal membrane oxygenation duration and incidence of complications, including surgical bleeding, neurologic injury, renal failure, inotrope use on extracorporeal membrane oxygenation, and bloodstream infection, were higher in nonsurvivors compared with survivors (P < .05 for all). In a multivariable model, neurologic injury (odds ratio, 5.18; 95% confidence interval, 1.97–13.61), surgical bleeding (odds ratio, 2.36; 95% confidence interval, 1.22–4.56), and renal failure (odds ratio, 2.81; 95% confidence interval, 1.41–5.59) increased mortality. Extracorporeal membrane oxygenation duration of more than 65 hours to 119 hours (odds ratio, 0.33; 95% confidence interval, 0.14–0.76) was associated with decreased mortality.ConclusionsCardiac failure requiring extracorporeal membrane oxygenation after the Fontan operation is associated with high mortality. Complications during extracorporeal membrane oxygenation support increase mortality odds. Prompt correction of surgical bleeding when possible may improve survival