Prevalence of type 1 diabetes among children aged 0–14 in Australia 2013

Prevalence of type 1 diabetes among children aged 0–14 in Australia 2013 presents the first national picture of children aged 0–14 living with type 1 diabetes in Australia. The report, based on data from the National (insulin-treated) Diabetes Register, highlights that in 2013, 6,091 children aged 0–14 had type 1 diabetes in Australia. This represented 139 cases per 100,000 population, or about 1 in 720 Australians aged 0–14. About 2 in 5 children with type 1 diabetes used an insulin pump to administer insulin. The prevalence of type 1 diabetes among children differed by age, state/territory, and residential remoteness areas

\u27Disembodied Bones\u27: recovering the poetry and prose of Elinor Wylie 2021

Picking a book to read is like diving for a pearl, writes Elinor Wylie, a 20th Century American poet, novelist, essayist and prominent magazine literary editor. In her essay The Pearl Diver , she writes that it is the diver that risks the unknown- unaided by diving equipment in the form of library indexes-who gains the greatest joy, Wylie states (Fugitive Prose, 869). Wylie explains: I venture to perceive an analogy between the rebellious pearl diver and myself, in my slight experience with public libraries...how much more delightful, how much more stimulating, to abandon the paraphernalia of card indexes and mahogany desks and slip unhampered into cool water; to snatch in the middle of a bursting breath the adventurous jewel or antique coin upon which one\u27s fingers chance to fall! (869) Today, it would take an unaided dive into the depths of the literary shoals that sank precious artworks to find the four novels and four poetry volumes Wylie gave the world in eight shining years. It was a Providential, unaided dive that brought me to Wylie\u27s jewels.I was perusing the free book tables in Suny Cortland\u27s English Department when I stumbled across the 1996 edition of The Norton Anthology of Literature by Women and clutched it as my very own. Later, I was looking through the anthology for a work by a different author when I stumbled upon Wylie\u27s Let No Charitable Hope , (1387). Here, in this poem, was the lived reality of womanhood. I marked the passage with a flashcard from my French class and came back to the author for my thesis. By this time I had read much more of Wylie\u27s poetry and prose and conducted an informal survey of my professors: Wylie\u27s lyrical creations were unheard of and unknown. Here was a writer- a contemporary of Robert Frost and Ernest Himengway [sic]- who wrote of nature\u27s grace like Frost, adhered to style and allegory as strictly as Hemmingway [sic], and used masterful technique to elucidate the same themes of rugged individualism and the futility of war. With Wylie I had taken an unaided dive and found a pearl

Characterization of the Subcellular Localization of DCBLD2 and its Regulation by Tyrosine Phosphorylation

DCBLD2 is a scaffolding receptor possibly involved in neuronal migration or differentiation. It contains seven intracellular tyrosine sites that can be phosphorylated to allow Crk/CrkL binding. Crk/CrkL are involved in the Reelin signaling pathway that regulates neuronal migration in the developing cortex. My research was aimed at understanding the subcellular localization of DCBLD2 and to determine if its ability to become tyrosine phosphorylated altered its localization. I hypothesized that DCBLD2 would localize similarly to NP1 and PlxnA2 based on their similar functions relayed to axon guidance and their similar ectodomains. DCBLD2 is termed a neuropilin-like protein as they have similar ectodomains. NP1 is a co-receptor to PlxnA2 and together they respond to semaphorins to regulate axonal guidance. Therefore, DCBLD2 might localize similarly to NP-1 and PlxnA2 within a cell. It is possible that the mutant version of DCBLD2, lacking the seven tyrosine sites, will localize differently than the wild type, perhaps driving it more or less towards the plasma membrane. I created three constructs to study DCBLD2 in human embryonic kidney cells. These constructs were visualized via immunofluorescence. From the images and statistical results, both DCBLD2 wild type and the phosphorylation site mutant localize similarly to PlxnA2

Observations of Trip Generation, Route Choice, and Trip Chaining with Private-Sector Probe Vehicle GPS Data

This paper presents an exploratory study of GPS data from a private-sector data provider for analysis of trip generation, route choice, and trip chaining. The study focuses on travel to and from the Indianapolis International Airport. GPS data consisting of nearly 1 billion waypoints for 12 million trips collected over a 6-week period in the state of Indiana. Within this data, there were approximately 10,000 trip records indicating travel to facilities associated with the Indianapolis airport. The analysis is based the matching of waypoints to geographic areas that define the extents of roadways and various destinations. A regional analysis of trip ends finds that travel demand for passenger services at the airport extends across a region spanning about 950 km. Local travel between land uses near the airport is examined by generation of an origin-destination matrix, and route choice between the airport and downtown Indianapolis is studied. Finally, the individual trips are scanned to identify trip chaining behavior. Several observations are made regarding these dynamics from the data. There is some sample bias (types of vehicles) and opportunities to further refine some of the land use definitions, but the study results suggest this type of data will provide a new frontier for characterizing travel demand patterns at a variety of scales

Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis

© 2020, The Author(s). Malnutrition predicts poorer clinical outcomes for people with cancer. Older adults with cancer are a complex, growing population at high risk of weight-losing conditions. A number of malnutrition screening tools exist, however the best screening tool for this group is unknown. The aim was to systematically review the published evidence regarding markers and measures of nutritional status in older adults with cancer (age ≥ 70). A systematic search was performed in Ovid Medline, EMBASE, Web of Science, CINAHL, British Nursing Database and Cochrane CENTRAL; search terms related to malnutrition, cancer, older adults. Titles, abstracts and papers were screened and quality-appraised. Data evaluating ability of markers of nutritional status to predict patient outcomes were subjected to meta-analysis or narrative synthesis. Forty-two studies, describing 15 markers were included. Meta-analysis found decreased food intake was associated with mortality (OR 2.15 [2.03–4.20] p = < 0.00001) in univariate analysis. Prognostic Nutritional Index (PNI) was associated with overall survival (HR 1.89 [1.03–3.48] p = 0.04). PNI markers (albumin, total lymphocyte count) could be seen as markers of inflammation rather than nutrition. There a suggested relationship between very low body mass index (BMI)

Visitation to Cottonseed Storage Sites by Feral Swine and Evidence of Gossypol Exposure

Texas ranks first in U.S. cotton production, and southern Texas is a major region of production within the state. Within Kleberg County, for example, approximately 16,147 ha are planted in cotton annually, yielding approximately 68,200 bales, or 15,467 metric tons, of cotton (U.S. Department of Agriculture [USDA] 2009). Cotton producers have discovered new uses for cotton ginned by-products, such as hydro-mulch (Holt et al. 2005) used as a protein supplement for range livestock (DelCurto et al. 2000) and white-tailed deer (Odocoileus virginianus; Cooper 2006). Because of this, much of the materials are temporarily stored for later use

A profile in FIRE: resolving the radial distributions of satellite galaxies in the Local Group with simulations

While many tensions between Local Group (LG) satellite galaxies and LCDM cosmology have been alleviated through recent cosmological simulations, the spatial distribution of satellites remains an important test of physical models and physical versus numerical disruption in simulations. Using the FIRE-2 cosmological zoom-in baryonic simulations, we examine the radial distributions of satellites with Mstar > 10^5 Msun around 8 isolated Milky Way- (MW) mass host galaxies and 4 hosts in LG-like pairs. We demonstrate that these simulations resolve the survival and physical destruction of satellites with Mstar >~ 10^5 Msun. The simulations broadly agree with LG observations, spanning the radial profiles around the MW and M31. This agreement does not depend strongly on satellite mass, even at distances <~ 100 kpc. Host-to-host variation dominates the scatter in satellite counts within 300 kpc of the hosts, while time variation dominates scatter within 50 kpc. More massive host galaxies within our sample have fewer satellites at small distances, likely because of enhanced tidal destruction of satellites via the baryonic disks of host galaxies. Furthermore, we quantify and provide fits to the tidal depletion of subhalos in baryonic relative to dark matter-only simulations as a function of distance. Our simulated profiles imply observational incompleteness in the LG even at Mstar >~ 10^5 Msun: we predict 2-10 such satellites to be discovered around the MW and possibly 6-9 around M31. To provide cosmological context, we compare our results with the radial profiles of satellites around MW analogs in the SAGA survey, finding that our simulations are broadly consistent with most SAGA systems.Comment: 18 pages, 10 figures, plus appendices. Main results in figures 2, 3, and 4. Accepted versio