News Stories of Intimate Partner Violence: An Experimental Examination of Participant Sex, Perpetrator Sex, and Violence Severity on Seriousness, Sympathy, and Punishment Preferences

This study experimentally examines the effects of participant sex, perpetrator sex, and severity of violence on perceptions of intimate partner violence (IPV) seriousness, sympathy toward the victim, and punishment preferences for the perpetrator. Participants (N = 449) were randomly assigned to a condition, exposed to a composite news story, and then completed a survey. Ratings of seriousness of IPV for stories with male perpetrators were significantly higher than ratings of seriousness for stories with female perpetrators. Men had significantly higher sympathy for female victims in any condition than for male victims in the weak or strong severity of violence conditions. Men’s sympathy for male victims in the fatal severity of violence condition did not differ from their sympathy for female victims. Women had the least sympathy for female victims in the weak severity condition and men in the weak or strong severity conditions. Women reported significantly higher sympathy for female victims in the strong and fatal severity of violence conditions. Women’s ratings of sympathy for male victims in the fatal severity of violence condition were statistically indistinguishable from any other group. Participants reported stronger punishment preferences for male perpetrators and this effect was magnified among men. Theoretical implications are presented with attention provided to practical considerations about support for public health services

Electronic Cigarettes in Maine: Health Effects, Marketing, Use, and Regulation

Electronic cigarettes (e-cigarettes) are electronic nicotine-delivery systems (ENDS) that deliver a vapor of nicotine and other potentially dangerous chemicals to the user; nonusers are also exposed. Driven by a well-funded advertising campaign, use of e-cigarettes has increased in Maine until it now exceeds the use of combustible cigarettes among youth. In 2015, 14.5 percent of female high school students and 18.8 percent of male high school students in Maine reported current use of e-cigarettes. Maine laws and city ordinances restrict e-cigarette use in some places where combustible cigarettes are banned, but legislative gaps remain. Most Maine schools, colleges, and hospitals also ban e-cigarettes, but again gaps remain. This article explores the marketing and use of e-cigarettes nationwide and in Maine and proposes policies to restrict access and use, particularly by youth

Outdoor Smoke-Free Policies in Maine

Incontrovertible evidence of the deadly impacts from both direct tobacco use and environmental exposure to tobacco smoke has led to the institution of smoking bans, first in indoor venues and, more recently, in some outdoor area. This article reviews the science behind smoking bans as well as the history and policy implications of smoking bans with an emphasis on the experience in Maine. As examples we focus on recent outdoor smoking bans in South Portland (parks and beaches) and smoke-free campus rules at a Maine hospital (Franklin Memorial Hospital) and a part of the University of Maine system (University of Southern Maine). Our conclusions highlight the interconnections among federal, state, municipal, and public institutional efforts to limit smoking and suggest pathways by which smoke-free areas can be expanded in Maine and elsewhere

Red giants in the outer halo of the elliptical galaxy NGC 5128 / Centaurus A

We used VIMOS on VLT to perform $V$ and $I$ band imaging of the outermost halo of NGC 5128 / Centaurus A ($(m-M)_0=27.91\pm0.08$), 65 kpc from the galaxy's center and along the major axis. The stellar population has been resolved to $I_0 \approx 27$ with a $50\%$ completeness limit of $I_0 = 24.7$, well below the tip of the red-giant branch (TRGB), which is seen at $I_0 \approx 23.9$. The surface density of NGC 5128 halo stars in our fields was sufficiently low that dim, unresolved background galaxies were a major contaminant in the source counts. We isolated a clean sample of red-giant-branch (RGB) stars extending to $\approx 0.8$ mag below the TRGB through conservative magnitude and color cuts, to remove the (predominantly blue) unresolved background galaxies. We derived stellar metallicities from colors of the stars via isochrones and measured the density falloff of the halo as a function of metallicity by combining our observations with HST imaging taken of NGC 5128 halo fields closer to the galaxy center. We found both metal-rich and metal-poor stellar populations and found that the falloff of the two follows the same de Vaucouleurs' law profiles from $\approx 8$ kpc out to $\approx$ 70 kpc. The metallicity distribution function (MDF) and the density falloff agree with the results of two recent studies of similar outermost halo fields in NGC 5128. We found no evidence of a "transition" in the radial profile of the halo, in which the metal-rich halo density would drop rapidly, leaving the underlying metal-poor halo to dominate by default out to greater radial extent, as has been seen in the outer halo of two other large galaxies. If NGC 5128 has such a transition, it must lie at larger galactocentric distances.Comment: Accepted for publication in A&A. 11 pages, including 14 figures and 1 tabl

A year in the life of a North Atlantic seabird: behavioural and energetic adjustments during the annual cycle

During their annual cycles, animals face a series of energetic challenges as they prioritise different life history events by engaging in temporally and potentially spatially segregated reproductive and non-breeding periods. Investigating behaviour and energy use across these periods is fundamental to understanding how animals survive the changing conditions associated with annual cycles. We estimated year-round activity budgets, energy expenditure, location, colony attendance and foraging behaviour for surviving individuals from a population of common guillemots Uria aalge. Despite the potential constraints of reduced day lengths and sea surface temperatures in winter, guillemots managed their energy expenditure throughout the year. Values were high prior to and during the breeding season, driven by a combination of high thermoregulatory costs, diving activity, colony attendance and associated flight. Guillemots also exhibited partial colony attendance outside the breeding season, likely supported by local resources. Additionally, there was a mismatch in the timing of peaks in dive effort and a peak in nocturnal foraging activity, indicating that guillemots adapted their foraging behaviour to the availability of prey rather than daylight. Our study identifies adaptations in foraging behaviour and flexibility in activity budgets as mechanisms that enable guillemots to manage their energy expenditure and survive the annual cycle

Small molecule inhibits T-cell acute lymphoblastic leukaemia oncogenic interaction through conformational modulation of LMO2

Ectopic expression in T-cell precursors of LIM only protein 2 (LMO2), a key factor in hematopoietic development, has been linked to the onset of T-cell acute lymphoblastic leukaemia (T-ALL). In the T-ALL context, LMO2 drives oncogenic progression through binding to erythroid-specific transcription factor SCL/TAL1 and sequestration of E-protein transcription factors, normally required for T-cell differentiation. A key requirement for the formation of this oncogenic protein-protein interaction (PPI) is the conformational flexibility of LMO2. Here we identify a small molecule inhibitor of the SCL-LMO2 PPI, which hinders the interaction in vitro through direct binding to LMO2. Biophysical analysis demonstrates that this inhibitor acts through a mechanism of conformational modulation of LMO2. Importantly, this work has led to the identification of a small molecule inhibitor of the SCL-LMO2 PPI, which can provide a starting point for the development of new agents for the treatment of T-ALL. These results suggest that similar approaches, based on the modulation of protein conformation by small molecules, might be used for therapeutic targeting of other oncogenic PPIs

The effect of adding comorbidities to current centers for disease control and prevention central-line–associated bloodstream infection risk-adjustment methodology

BACKGROUNDRisk adjustment is needed to fairly compare central-line–associated bloodstream infection (CLABSI) rates between hospitals. Until 2017, the Centers for Disease Control and Prevention (CDC) methodology adjusted CLABSI rates only by type of intensive care unit (ICU). The 2017 CDC models also adjust for hospital size and medical school affiliation. We hypothesized that risk adjustment would be improved by including patient demographics and comorbidities from electronically available hospital discharge codes.METHODSUsing a cohort design across 22 hospitals, we analyzed data from ICU patients admitted between January 2012 and December 2013. Demographics and International Classification of Diseases, Ninth Edition, Clinical Modification (ICD-9-CM) discharge codes were obtained for each patient, and CLABSIs were identified by trained infection preventionists. Models adjusting only for ICU type and for ICU type plus patient case mix were built and compared using discrimination and standardized infection ratio (SIR). Hospitals were ranked by SIR for each model to examine and compare the changes in rank.RESULTSOverall, 85,849 ICU patients were analyzed and 162 (0.2%) developed CLABSI. The significant variables added to the ICU model were coagulopathy, paralysis, renal failure, malnutrition, and age. The C statistics were 0.55 (95% CI, 0.51–0.59) for the ICU-type model and 0.64 (95% CI, 0.60–0.69) for the ICU-type plus patient case-mix model. When the hospitals were ranked by adjusted SIRs, 10 hospitals (45%) changed rank when comorbidity was added to the ICU-type model.CONCLUSIONSOur risk-adjustment model for CLABSI using electronically available comorbidities demonstrated better discrimination than did the CDC model. The CDC should strongly consider comorbidity-based risk adjustment to more accurately compare CLABSI rates across hospitals.Infect Control Hosp Epidemiol 2017;38:1019–1024</jats:sec